Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma

The KiHAC Respiratory Medicine Group

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Type-2/eosinophilic inflammation plays a pivotal role in asthma. The identification of severe type-2/eosinophilic asthma is important for improving the management of patients with asthma. Therefore, efforts to develop non-invasive biomarkers for type-2/eosinophilic airway inflammation have been made during this decade. Currently, fraction of exhaled nitric oxide (FeNO) and serum periostin levels are considered markers of type-2/eosinophilic inflammation in asthma. However, a single-marker approach has limited the ability to diagnose severe type-2/eosinophilic asthma accurately and predict disease outcomes precisely. The present article reviews the utility of FeNO and serum periostin levels in a single-marker approach and in a multiple-marker approach in identifying patients with severe type-2/eosinophilic asthma. Furthermore, based on a sub-analysis of the Kinki Hokuriku Airway disease Conference (KiHAC), geno-endo-phenotypes of patients were stratified into four groups according to the FeNO and serum periostin levels.

Original languageEnglish
Pages (from-to)404-410
Number of pages7
JournalAllergology International
Issue number3
Publication statusPublished - 07-2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy


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