Utility of the Serum Cystatin C level for diagnosis of osteoporosis among middle-aged and elderly people

Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Koji Suzuki, Taisuke Seki, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama

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Abstract

Purpose. Osteoporosis is a common age-related disorder leading to increased bone fragility and risk of fracture. Early diagnosis of osteoporosis is a vital step in providing early therapeutic intervention. Serum cystatin C is a marker of early renal dysfunction, a predictor of cardiovascular and inflammatory diseases, and an inhibitor of the differentiation of osteoclast precursor cells. The purpose of this study was to evaluate the relationship between serum cystatin C and osteoporosis. Methods. We enrolled 46 subjects who attended a health checkup and underwent measurement of bone status by quantitative ultrasound and determination of the level of serum cystatin C. A comparative study was conducted between those with and without osteoporosis for all subjects collectively and in two subgroups aged <65 and ≥65 years. Results. Serum cystatin C levels were strongly correlated with age, creatinine, and bone status data, with significant negative correlations with stiffness, T-score, and percentage of young adult mean. Among patients with osteoporosis, serum cystatin C was significantly higher even after adjustment for age and sex, whereas no significant difference was noted in creatinine. For patients aged ≥ 65 years, serum cystatin C was significantly higher in subjects with osteoporosis, although there was no significant difference in age between normal subjects and those with osteoporosis. Conclusions. To the best of our knowledge, this is the first study to demonstrate an association between serum cystatin C and osteoporosis. Serum cystatin C is significantly higher in osteoporosis and in particular may be a useful marker for osteoporosis among middle and elderly people aged ≥ 65 years. Measurement of serum cystatin C can be carried out easily and may contribute to early diagnosis and treatment of osteoporosis.

Original languageEnglish
Article number5046852
JournalBioMed Research International
Volume2019
DOIs
Publication statusPublished - 01-01-2019

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Cystatin C
Osteoporosis
Serum
Bone
Creatinine
Bone and Bones
Early Diagnosis
Osteoclasts
Ultrasonics
Stiffness
Health
Young Adult
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Tanaka, S., Ando, K., Kobayashi, K., Hida, T., Ito, K., Tsushima, M., ... Imagama, S. (2019). Utility of the Serum Cystatin C level for diagnosis of osteoporosis among middle-aged and elderly people. BioMed Research International, 2019, [5046852]. https://doi.org/10.1155/2019/5046852
Tanaka, Satoshi ; Ando, Kei ; Kobayashi, Kazuyoshi ; Hida, Tetsuro ; Ito, Kenyu ; Tsushima, Mikito ; Morozumi, Masayoshi ; Machino, Masaaki ; Ota, Kyotaro ; Suzuki, Koji ; Seki, Taisuke ; Ishiguro, Naoki ; Hasegawa, Yukiharu ; Imagama, Shiro. / Utility of the Serum Cystatin C level for diagnosis of osteoporosis among middle-aged and elderly people. In: BioMed Research International. 2019 ; Vol. 2019.
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abstract = "Purpose. Osteoporosis is a common age-related disorder leading to increased bone fragility and risk of fracture. Early diagnosis of osteoporosis is a vital step in providing early therapeutic intervention. Serum cystatin C is a marker of early renal dysfunction, a predictor of cardiovascular and inflammatory diseases, and an inhibitor of the differentiation of osteoclast precursor cells. The purpose of this study was to evaluate the relationship between serum cystatin C and osteoporosis. Methods. We enrolled 46 subjects who attended a health checkup and underwent measurement of bone status by quantitative ultrasound and determination of the level of serum cystatin C. A comparative study was conducted between those with and without osteoporosis for all subjects collectively and in two subgroups aged <65 and ≥65 years. Results. Serum cystatin C levels were strongly correlated with age, creatinine, and bone status data, with significant negative correlations with stiffness, T-score, and percentage of young adult mean. Among patients with osteoporosis, serum cystatin C was significantly higher even after adjustment for age and sex, whereas no significant difference was noted in creatinine. For patients aged ≥ 65 years, serum cystatin C was significantly higher in subjects with osteoporosis, although there was no significant difference in age between normal subjects and those with osteoporosis. Conclusions. To the best of our knowledge, this is the first study to demonstrate an association between serum cystatin C and osteoporosis. Serum cystatin C is significantly higher in osteoporosis and in particular may be a useful marker for osteoporosis among middle and elderly people aged ≥ 65 years. Measurement of serum cystatin C can be carried out easily and may contribute to early diagnosis and treatment of osteoporosis.",
author = "Satoshi Tanaka and Kei Ando and Kazuyoshi Kobayashi and Tetsuro Hida and Kenyu Ito and Mikito Tsushima and Masayoshi Morozumi and Masaaki Machino and Kyotaro Ota and Koji Suzuki and Taisuke Seki and Naoki Ishiguro and Yukiharu Hasegawa and Shiro Imagama",
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Tanaka, S, Ando, K, Kobayashi, K, Hida, T, Ito, K, Tsushima, M, Morozumi, M, Machino, M, Ota, K, Suzuki, K, Seki, T, Ishiguro, N, Hasegawa, Y & Imagama, S 2019, 'Utility of the Serum Cystatin C level for diagnosis of osteoporosis among middle-aged and elderly people' BioMed Research International, vol. 2019, 5046852. https://doi.org/10.1155/2019/5046852

Utility of the Serum Cystatin C level for diagnosis of osteoporosis among middle-aged and elderly people. / Tanaka, Satoshi; Ando, Kei; Kobayashi, Kazuyoshi; Hida, Tetsuro; Ito, Kenyu; Tsushima, Mikito; Morozumi, Masayoshi; Machino, Masaaki; Ota, Kyotaro; Suzuki, Koji; Seki, Taisuke; Ishiguro, Naoki; Hasegawa, Yukiharu; Imagama, Shiro.

In: BioMed Research International, Vol. 2019, 5046852, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Utility of the Serum Cystatin C level for diagnosis of osteoporosis among middle-aged and elderly people

AU - Tanaka, Satoshi

AU - Ando, Kei

AU - Kobayashi, Kazuyoshi

AU - Hida, Tetsuro

AU - Ito, Kenyu

AU - Tsushima, Mikito

AU - Morozumi, Masayoshi

AU - Machino, Masaaki

AU - Ota, Kyotaro

AU - Suzuki, Koji

AU - Seki, Taisuke

AU - Ishiguro, Naoki

AU - Hasegawa, Yukiharu

AU - Imagama, Shiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose. Osteoporosis is a common age-related disorder leading to increased bone fragility and risk of fracture. Early diagnosis of osteoporosis is a vital step in providing early therapeutic intervention. Serum cystatin C is a marker of early renal dysfunction, a predictor of cardiovascular and inflammatory diseases, and an inhibitor of the differentiation of osteoclast precursor cells. The purpose of this study was to evaluate the relationship between serum cystatin C and osteoporosis. Methods. We enrolled 46 subjects who attended a health checkup and underwent measurement of bone status by quantitative ultrasound and determination of the level of serum cystatin C. A comparative study was conducted between those with and without osteoporosis for all subjects collectively and in two subgroups aged <65 and ≥65 years. Results. Serum cystatin C levels were strongly correlated with age, creatinine, and bone status data, with significant negative correlations with stiffness, T-score, and percentage of young adult mean. Among patients with osteoporosis, serum cystatin C was significantly higher even after adjustment for age and sex, whereas no significant difference was noted in creatinine. For patients aged ≥ 65 years, serum cystatin C was significantly higher in subjects with osteoporosis, although there was no significant difference in age between normal subjects and those with osteoporosis. Conclusions. To the best of our knowledge, this is the first study to demonstrate an association between serum cystatin C and osteoporosis. Serum cystatin C is significantly higher in osteoporosis and in particular may be a useful marker for osteoporosis among middle and elderly people aged ≥ 65 years. Measurement of serum cystatin C can be carried out easily and may contribute to early diagnosis and treatment of osteoporosis.

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