Vancomycin-resistant enterococci in humans and imported chickens in Japan

Yoshiyuki Ozawa; Koichi Tanimoto; Takahiro Nomura; Masao Yoshinaga; Yoshichika Arakawa; Yasuyoshi Ike

doi:10.1128/AEM.68.12.6457-6461.2002

Vancomycin-resistant enterococci in humans and imported chickens in Japan

Yoshiyuki Ozawa, Koichi Tanimoto, Takahiro Nomura, Masao Yoshinaga, Yoshichika Arakawa, Yasuyoshi Ike

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The phenotypes and genotypes of 22 VanA-type vancomycin-resistant enterococci that had been isolated in Japan were examined. The VanA resistance determinant was plasmid mediated in each of the 22 strains. Of the 22 strains, 8 were isolated from different patients and 11 and 3 were obtained from different samples of chickens imported from Thailand and France, respectively. Three of the strains that were isolated from patients and the 11 strains isolated from the Thai chickens showed high-level vancomycin resistance (MICs, 512 to 1,024 μg/ml) and low-level teicoplanin resistance (MICs, 0.5 to 4 μg/ml). Each of these strains had three amino acid substitutions in the N-terminal region of the deduced VanS sequence. L50 was converted to V, E54 was converted to Q, and Q69 was converted to H compared to the vanS gene sequence of Tn1546.

Original language	English
Pages (from-to)	6457-6461
Number of pages	5
Journal	Applied and Environmental Microbiology
Volume	68
Issue number	12
DOIs	https://doi.org/10.1128/AEM.68.12.6457-6461.2002
Publication status	Published - 01-12-2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Food Science
Ecology
Applied Microbiology and Biotechnology

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10.1128/AEM.68.12.6457-6461.2002

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abstract = "The phenotypes and genotypes of 22 VanA-type vancomycin-resistant enterococci that had been isolated in Japan were examined. The VanA resistance determinant was plasmid mediated in each of the 22 strains. Of the 22 strains, 8 were isolated from different patients and 11 and 3 were obtained from different samples of chickens imported from Thailand and France, respectively. Three of the strains that were isolated from patients and the 11 strains isolated from the Thai chickens showed high-level vancomycin resistance (MICs, 512 to 1,024 μg/ml) and low-level teicoplanin resistance (MICs, 0.5 to 4 μg/ml). Each of these strains had three amino acid substitutions in the N-terminal region of the deduced VanS sequence. L50 was converted to V, E54 was converted to Q, and Q69 was converted to H compared to the vanS gene sequence of Tn1546.",

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AU - Ozawa, Yoshiyuki

AU - Tanimoto, Koichi

AU - Nomura, Takahiro

AU - Yoshinaga, Masao

AU - Arakawa, Yoshichika

AU - Ike, Yasuyoshi

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The phenotypes and genotypes of 22 VanA-type vancomycin-resistant enterococci that had been isolated in Japan were examined. The VanA resistance determinant was plasmid mediated in each of the 22 strains. Of the 22 strains, 8 were isolated from different patients and 11 and 3 were obtained from different samples of chickens imported from Thailand and France, respectively. Three of the strains that were isolated from patients and the 11 strains isolated from the Thai chickens showed high-level vancomycin resistance (MICs, 512 to 1,024 μg/ml) and low-level teicoplanin resistance (MICs, 0.5 to 4 μg/ml). Each of these strains had three amino acid substitutions in the N-terminal region of the deduced VanS sequence. L50 was converted to V, E54 was converted to Q, and Q69 was converted to H compared to the vanS gene sequence of Tn1546.

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Vancomycin-resistant enterococci in humans and imported chickens in Japan

Abstract

All Science Journal Classification (ASJC) codes

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