Variable susceptibility of ovarian cancer cells to non- Thermal plasma- Activated medium

Fumi Utsumi, Hiroaki Kajiyama, Kae Nakamura, Hiromasa Tanaka, Masaaki Mizuno, Shinnya Toyokuni, Masaru Hori, Fumitaka Kikkawa

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Non- Thermal atmospheric pressure plasma has been widely studied in recent years in many fields,including cancer treatment. However,its efficiency for inducing apoptosis sometimes varies depending on the cell species and experimental conditions. The aim of this study was to elucidate what causes these differences in responses to plasma treatment. Using four ovarian cancer cell lines,the cell density had a markedly negative impact on the proliferation inhibition rate (PIR) and it was more obvious in OVCAR-3 and NOS2 cells. Furthermore,TOV21G and ES-2 cells were drastically sensitive to plasma- Activated medium (PAM) compared with the other two cell lines. We demonstrated that the proportion of reactive oxygen species and cell number had a marked impact on the effect of PAM against ovarian cancer cells. Additionally it was suggested that the morphological features of cells were also closely related to the sensitivity of cancer cells to the plasma treatment.

Original languageEnglish
Pages (from-to)3169-3177
Number of pages9
JournalOncology reports
Issue number6
Publication statusPublished - 06-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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