Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population

for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group

Research output: Contribution to journalArticle

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Abstract

Background: Circadian rhythm disruptions can cause various health disorders. The present study evaluated associations between single nucleotide polymorphisms in the core circadian gene clock circadian regulator (CLOCK) and the prevalence of type 2 diabetes (T2D) in the Japanese population. Methods: Cross-sectional data were analyzed from 2485 subjects (1243 men, 1242 women; age 35–69 years) enrolled in the baseline surveys of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Associations between three CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and the prevalence of obesity (body mass index [BMI] ≥25 kg/m2), overweight (BMI ≥23 kg/m2), and T2D were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for the prevalence of diabetes were also conducted. Results: Compared with those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C had a significantly higher odds ratio (1.5; 95% confidence interval 1.1–2.1) for the prevalence of diabetes after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and the prevalence of diabetes were marked and significant in non-overweight subjects, but not in overweight subjects. The TGA (rs1801260–rs3736544–rs4864548) haplotype was associated with a lower prevalence of diabetes, whereas the CGG haplotype was associated with a higher prevalence of diabetes. Conclusions: Variant of the CLOCK gene and related haplotypes are associated with the prevalence of T2D in the Japanese population, in which obesity is less common, and the association between CLOCK gene variant at rs1801260 and the prevalence of diabetes is enhanced in normal-weight subjects.

Original languageEnglish
Pages (from-to)667-676
Number of pages10
JournalJournal of Diabetes
Volume8
Issue number5
DOIs
Publication statusPublished - 01-09-2016

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Circadian Clocks
Regulator Genes
Type 2 Diabetes Mellitus
Haplotypes
Population
Body Mass Index
Genes
Obesity
Alleles
Circadian Rhythm
Single Nucleotide Polymorphism
Japan
Cohort Studies
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group. / Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. In: Journal of Diabetes. 2016 ; Vol. 8, No. 5. pp. 667-676.
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abstract = "Background: Circadian rhythm disruptions can cause various health disorders. The present study evaluated associations between single nucleotide polymorphisms in the core circadian gene clock circadian regulator (CLOCK) and the prevalence of type 2 diabetes (T2D) in the Japanese population. Methods: Cross-sectional data were analyzed from 2485 subjects (1243 men, 1242 women; age 35–69 years) enrolled in the baseline surveys of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Associations between three CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and the prevalence of obesity (body mass index [BMI] ≥25 kg/m2), overweight (BMI ≥23 kg/m2), and T2D were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for the prevalence of diabetes were also conducted. Results: Compared with those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C had a significantly higher odds ratio (1.5; 95{\%} confidence interval 1.1–2.1) for the prevalence of diabetes after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and the prevalence of diabetes were marked and significant in non-overweight subjects, but not in overweight subjects. The TGA (rs1801260–rs3736544–rs4864548) haplotype was associated with a lower prevalence of diabetes, whereas the CGG haplotype was associated with a higher prevalence of diabetes. Conclusions: Variant of the CLOCK gene and related haplotypes are associated with the prevalence of T2D in the Japanese population, in which obesity is less common, and the association between CLOCK gene variant at rs1801260 and the prevalence of diabetes is enhanced in normal-weight subjects.",
author = "{for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group} and Hirokazu Uemura and Sakurako Katsuura-Kamano and Miwa Yamaguchi and Kokichi Arisawa and Nobuyuki Hamajima and Asahi Hishida and Sayo Kawai and Isao Oze and Koichi Shinchi and Naoyuki Takashima and Sadao Suzuki and Noriko Nakahata and Haruo Mikami and Keizo Ohnaka and Nagato Kuriyama and Michiaki Kubo and Michiaki Kubo",
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Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. / for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

In: Journal of Diabetes, Vol. 8, No. 5, 01.09.2016, p. 667-676.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population

AU - for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group

AU - Uemura, Hirokazu

AU - Katsuura-Kamano, Sakurako

AU - Yamaguchi, Miwa

AU - Arisawa, Kokichi

AU - Hamajima, Nobuyuki

AU - Hishida, Asahi

AU - Kawai, Sayo

AU - Oze, Isao

AU - Shinchi, Koichi

AU - Takashima, Naoyuki

AU - Suzuki, Sadao

AU - Nakahata, Noriko

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Kuriyama, Nagato

AU - Kubo, Michiaki

AU - Kubo, Michiaki

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background: Circadian rhythm disruptions can cause various health disorders. The present study evaluated associations between single nucleotide polymorphisms in the core circadian gene clock circadian regulator (CLOCK) and the prevalence of type 2 diabetes (T2D) in the Japanese population. Methods: Cross-sectional data were analyzed from 2485 subjects (1243 men, 1242 women; age 35–69 years) enrolled in the baseline surveys of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Associations between three CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and the prevalence of obesity (body mass index [BMI] ≥25 kg/m2), overweight (BMI ≥23 kg/m2), and T2D were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for the prevalence of diabetes were also conducted. Results: Compared with those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C had a significantly higher odds ratio (1.5; 95% confidence interval 1.1–2.1) for the prevalence of diabetes after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and the prevalence of diabetes were marked and significant in non-overweight subjects, but not in overweight subjects. The TGA (rs1801260–rs3736544–rs4864548) haplotype was associated with a lower prevalence of diabetes, whereas the CGG haplotype was associated with a higher prevalence of diabetes. Conclusions: Variant of the CLOCK gene and related haplotypes are associated with the prevalence of T2D in the Japanese population, in which obesity is less common, and the association between CLOCK gene variant at rs1801260 and the prevalence of diabetes is enhanced in normal-weight subjects.

AB - Background: Circadian rhythm disruptions can cause various health disorders. The present study evaluated associations between single nucleotide polymorphisms in the core circadian gene clock circadian regulator (CLOCK) and the prevalence of type 2 diabetes (T2D) in the Japanese population. Methods: Cross-sectional data were analyzed from 2485 subjects (1243 men, 1242 women; age 35–69 years) enrolled in the baseline surveys of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Associations between three CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and the prevalence of obesity (body mass index [BMI] ≥25 kg/m2), overweight (BMI ≥23 kg/m2), and T2D were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for the prevalence of diabetes were also conducted. Results: Compared with those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C had a significantly higher odds ratio (1.5; 95% confidence interval 1.1–2.1) for the prevalence of diabetes after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and the prevalence of diabetes were marked and significant in non-overweight subjects, but not in overweight subjects. The TGA (rs1801260–rs3736544–rs4864548) haplotype was associated with a lower prevalence of diabetes, whereas the CGG haplotype was associated with a higher prevalence of diabetes. Conclusions: Variant of the CLOCK gene and related haplotypes are associated with the prevalence of T2D in the Japanese population, in which obesity is less common, and the association between CLOCK gene variant at rs1801260 and the prevalence of diabetes is enhanced in normal-weight subjects.

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U2 - 10.1111/1753-0407.12344

DO - 10.1111/1753-0407.12344

M3 - Article

VL - 8

SP - 667

EP - 676

JO - Journal of Diabetes

JF - Journal of Diabetes

SN - 1753-0393

IS - 5

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