Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers

Daiki Miki, Hidenori Ochi, C. Nelson Hayes, Hiromi Abe, Tadahiko Yoshima, Hiroshi Aikata, Kenji Ikeda, Hiromitsu Kumada, Joji Toyota, Takashi Morizono, Tatsuhiko Tsunoda, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Kazuaki Chayama

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22 associated with HCC risk and confirmed the association using an independent case-control population (710 cases and 1,625 controls). The association was highly significant when we analyzed the stages separately as well as together (rs1012068, P combined = 1.27 × 10 -13, odds ratio = 1.75). The significance level of the association further increased after adjustment for gender, age and platelet count (P = 1.35 × 10 -14, odds ratio = 1.96). Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalNature Genetics
Volume43
Issue number8
DOIs
Publication statusPublished - 01-08-2011
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Hepacivirus
Hepatocellular Carcinoma
Single Nucleotide Polymorphism
Odds Ratio
Chromosomes, Human, Pair 22
Virus Diseases
Chronic Hepatitis
Platelet Count
Population

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Miki, Daiki ; Ochi, Hidenori ; Hayes, C. Nelson ; Abe, Hiromi ; Yoshima, Tadahiko ; Aikata, Hiroshi ; Ikeda, Kenji ; Kumada, Hiromitsu ; Toyota, Joji ; Morizono, Takashi ; Tsunoda, Tatsuhiko ; Kubo, Michiaki ; Nakamura, Yusuke ; Kamatani, Naoyuki ; Chayama, Kazuaki. / Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. In: Nature Genetics. 2011 ; Vol. 43, No. 8. pp. 797-800.
@article{e3921a654bce46efb6aa087c1caeac29,
title = "Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers",
abstract = "Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22 associated with HCC risk and confirmed the association using an independent case-control population (710 cases and 1,625 controls). The association was highly significant when we analyzed the stages separately as well as together (rs1012068, P combined = 1.27 × 10 -13, odds ratio = 1.75). The significance level of the association further increased after adjustment for gender, age and platelet count (P = 1.35 × 10 -14, odds ratio = 1.96). Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection.",
author = "Daiki Miki and Hidenori Ochi and Hayes, {C. Nelson} and Hiromi Abe and Tadahiko Yoshima and Hiroshi Aikata and Kenji Ikeda and Hiromitsu Kumada and Joji Toyota and Takashi Morizono and Tatsuhiko Tsunoda and Michiaki Kubo and Yusuke Nakamura and Naoyuki Kamatani and Kazuaki Chayama",
year = "2011",
month = "8",
day = "1",
doi = "10.1038/ng.876",
language = "English",
volume = "43",
pages = "797--800",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",

}

Miki, D, Ochi, H, Hayes, CN, Abe, H, Yoshima, T, Aikata, H, Ikeda, K, Kumada, H, Toyota, J, Morizono, T, Tsunoda, T, Kubo, M, Nakamura, Y, Kamatani, N & Chayama, K 2011, 'Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers', Nature Genetics, vol. 43, no. 8, pp. 797-800. https://doi.org/10.1038/ng.876

Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. / Miki, Daiki; Ochi, Hidenori; Hayes, C. Nelson; Abe, Hiromi; Yoshima, Tadahiko; Aikata, Hiroshi; Ikeda, Kenji; Kumada, Hiromitsu; Toyota, Joji; Morizono, Takashi; Tsunoda, Tatsuhiko; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Chayama, Kazuaki.

In: Nature Genetics, Vol. 43, No. 8, 01.08.2011, p. 797-800.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers

AU - Miki, Daiki

AU - Ochi, Hidenori

AU - Hayes, C. Nelson

AU - Abe, Hiromi

AU - Yoshima, Tadahiko

AU - Aikata, Hiroshi

AU - Ikeda, Kenji

AU - Kumada, Hiromitsu

AU - Toyota, Joji

AU - Morizono, Takashi

AU - Tsunoda, Tatsuhiko

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Kamatani, Naoyuki

AU - Chayama, Kazuaki

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22 associated with HCC risk and confirmed the association using an independent case-control population (710 cases and 1,625 controls). The association was highly significant when we analyzed the stages separately as well as together (rs1012068, P combined = 1.27 × 10 -13, odds ratio = 1.75). The significance level of the association further increased after adjustment for gender, age and platelet count (P = 1.35 × 10 -14, odds ratio = 1.96). Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection.

AB - Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22 associated with HCC risk and confirmed the association using an independent case-control population (710 cases and 1,625 controls). The association was highly significant when we analyzed the stages separately as well as together (rs1012068, P combined = 1.27 × 10 -13, odds ratio = 1.75). The significance level of the association further increased after adjustment for gender, age and platelet count (P = 1.35 × 10 -14, odds ratio = 1.96). Our findings suggest that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection.

UR - http://www.scopus.com/inward/record.url?scp=79960909219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960909219&partnerID=8YFLogxK

U2 - 10.1038/ng.876

DO - 10.1038/ng.876

M3 - Article

VL - 43

SP - 797

EP - 800

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -