Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations

Daiki Miki, Michiaki Kubo, Atsushi Takahashi, Kyong Ah Yoon, Jeongseon Kim, Geon Kook Lee, Jae Ill Zo, Jin Soo Lee, Naoya Hosono, Takashi Morizono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kazuaki Chayama, Takashi Takahashi, Johji Inazawa, Yusuke Nakamura, Yataro Daigo

Research output: Contribution to journalArticlepeer-review

131 Citations (Scopus)

Abstract

Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10 -11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10 -12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.

Original languageEnglish
Pages (from-to)893-896
Number of pages4
JournalNature Genetics
Volume42
Issue number10
DOIs
Publication statusPublished - 01-10-2010

All Science Journal Classification (ASJC) codes

  • Genetics

Fingerprint Dive into the research topics of 'Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations'. Together they form a unique fingerprint.

Cite this