Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations

Daiki Miki, Michiaki Kubo, Atsushi Takahashi, Kyong Ah Yoon, Jeongseon Kim, Geon Kook Lee, Jae Ill Zo, Jin Soo Lee, Naoya Hosono, Takashi Morizono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kazuaki Chayama, Takashi Takahashi, Johji Inazawa, Yusuke Nakamura, Yataro Daigo

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10 -11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10 -12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.

Original languageEnglish
Pages (from-to)893-896
Number of pages4
JournalNature Genetics
Volume42
Issue number10
DOIs
Publication statusPublished - 01-10-2010

Fingerprint

Population
Odds Ratio
Genome-Wide Association Study
Introns
Single Nucleotide Polymorphism
Cause of Death
Lung Neoplasms
Adenocarcinoma of lung
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Miki, Daiki ; Kubo, Michiaki ; Takahashi, Atsushi ; Yoon, Kyong Ah ; Kim, Jeongseon ; Lee, Geon Kook ; Zo, Jae Ill ; Lee, Jin Soo ; Hosono, Naoya ; Morizono, Takashi ; Tsunoda, Tatsuhiko ; Kamatani, Naoyuki ; Chayama, Kazuaki ; Takahashi, Takashi ; Inazawa, Johji ; Nakamura, Yusuke ; Daigo, Yataro. / Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. In: Nature Genetics. 2010 ; Vol. 42, No. 10. pp. 893-896.
@article{ec07f5f308414c09ab13b0e8ff9f5f86,
title = "Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations",
abstract = "Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10 -11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10 -12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.",
author = "Daiki Miki and Michiaki Kubo and Atsushi Takahashi and Yoon, {Kyong Ah} and Jeongseon Kim and Lee, {Geon Kook} and Zo, {Jae Ill} and Lee, {Jin Soo} and Naoya Hosono and Takashi Morizono and Tatsuhiko Tsunoda and Naoyuki Kamatani and Kazuaki Chayama and Takashi Takahashi and Johji Inazawa and Yusuke Nakamura and Yataro Daigo",
year = "2010",
month = "10",
day = "1",
doi = "10.1038/ng.667",
language = "English",
volume = "42",
pages = "893--896",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",

}

Miki, D, Kubo, M, Takahashi, A, Yoon, KA, Kim, J, Lee, GK, Zo, JI, Lee, JS, Hosono, N, Morizono, T, Tsunoda, T, Kamatani, N, Chayama, K, Takahashi, T, Inazawa, J, Nakamura, Y & Daigo, Y 2010, 'Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations', Nature Genetics, vol. 42, no. 10, pp. 893-896. https://doi.org/10.1038/ng.667

Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. / Miki, Daiki; Kubo, Michiaki; Takahashi, Atsushi; Yoon, Kyong Ah; Kim, Jeongseon; Lee, Geon Kook; Zo, Jae Ill; Lee, Jin Soo; Hosono, Naoya; Morizono, Takashi; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Chayama, Kazuaki; Takahashi, Takashi; Inazawa, Johji; Nakamura, Yusuke; Daigo, Yataro.

In: Nature Genetics, Vol. 42, No. 10, 01.10.2010, p. 893-896.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations

AU - Miki, Daiki

AU - Kubo, Michiaki

AU - Takahashi, Atsushi

AU - Yoon, Kyong Ah

AU - Kim, Jeongseon

AU - Lee, Geon Kook

AU - Zo, Jae Ill

AU - Lee, Jin Soo

AU - Hosono, Naoya

AU - Morizono, Takashi

AU - Tsunoda, Tatsuhiko

AU - Kamatani, Naoyuki

AU - Chayama, Kazuaki

AU - Takahashi, Takashi

AU - Inazawa, Johji

AU - Nakamura, Yusuke

AU - Daigo, Yataro

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10 -11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10 -12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.

AB - Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10 -11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10 -12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.

UR - http://www.scopus.com/inward/record.url?scp=77957588624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957588624&partnerID=8YFLogxK

U2 - 10.1038/ng.667

DO - 10.1038/ng.667

M3 - Article

C2 - 20871597

AN - SCOPUS:77957588624

VL - 42

SP - 893

EP - 896

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -