Varicella‐zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden death

YOSHIZO ASANO, Tetsushi Yoshikawa, ATSUO URISU, TAKEHIKO YAZAKI, YOSHIKAZU MIZOGUCHI, TAKESHI KURATA

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pathological findings of an otherwise healthy 17 month old boy who was exposed to Varicella‐zoster virus (VZV) in his family and unexpectedly died 3 days after onset of varicella are reported. They showed a disseminated VZV infection with involvement of skin, lung, liver, spleen, gastrointestinal tract and other organs where VZV antigen was detected by the enzyme‐immunoassay with monoclonal antibodies to VZV. Since the subject was the full‐term product of an uncomplicated pregnancy, who grew and developed normally, and had no symptoms or laboratory findings suggestive of immunodeficiency until his death, these findings suggest that many organs are involved as major internal sites of viral replication before or during infection of skin with VZV in the immunocompetent host. 1993 Japan Pediatric Society

Original languageEnglish
Pages (from-to)348-351
Number of pages4
JournalPediatrics International
Volume35
Issue number4
DOIs
Publication statusPublished - 01-01-1993

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Chickenpox
Virus Replication
Sudden Death
Viruses
Skin
Virus Diseases
Gastrointestinal Tract
Japan
Spleen
Monoclonal Antibodies
Pediatrics
Antigens
Pregnancy
Lung
Liver
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

ASANO, YOSHIZO ; Yoshikawa, Tetsushi ; URISU, ATSUO ; YAZAKI, TAKEHIKO ; MIZOGUCHI, YOSHIKAZU ; KURATA, TAKESHI. / Varicella‐zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden death. In: Pediatrics International. 1993 ; Vol. 35, No. 4. pp. 348-351.
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Varicella‐zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden death. / ASANO, YOSHIZO; Yoshikawa, Tetsushi; URISU, ATSUO; YAZAKI, TAKEHIKO; MIZOGUCHI, YOSHIKAZU; KURATA, TAKESHI.

In: Pediatrics International, Vol. 35, No. 4, 01.01.1993, p. 348-351.

Research output: Contribution to journalArticle

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T1 - Varicella‐zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden death

AU - ASANO, YOSHIZO

AU - Yoshikawa, Tetsushi

AU - URISU, ATSUO

AU - YAZAKI, TAKEHIKO

AU - MIZOGUCHI, YOSHIKAZU

AU - KURATA, TAKESHI

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AB - Pathological findings of an otherwise healthy 17 month old boy who was exposed to Varicella‐zoster virus (VZV) in his family and unexpectedly died 3 days after onset of varicella are reported. They showed a disseminated VZV infection with involvement of skin, lung, liver, spleen, gastrointestinal tract and other organs where VZV antigen was detected by the enzyme‐immunoassay with monoclonal antibodies to VZV. Since the subject was the full‐term product of an uncomplicated pregnancy, who grew and developed normally, and had no symptoms or laboratory findings suggestive of immunodeficiency until his death, these findings suggest that many organs are involved as major internal sites of viral replication before or during infection of skin with VZV in the immunocompetent host. 1993 Japan Pediatric Society

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