Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy

Sherifa A. Hamed, Enas A. Hamed, Ragaa Hamdy, Toshitaka Nabeshima

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Purpose: This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. Methods: This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c and LDL-c), total homocysteine (tHcy), von Willbrand factor (vWF), fibrinogen, oxidized LDL (Ox-LDL), malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARs), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GSH.Px), were assessed. Results: Compared to control group, the IMT of patients' common carotid artery, bifurcation area and internal carotid arteries was significantly thickened in 51.1%, 73.3% and 43.6% in various groups of patients (treated and untreated). In the studied patients, the levels of tHcy, vWF, fibrinogen, MDA, TBARs, Ox-LDL levels were increased while HDL-c and TAC were decreased. Patients on CBZ showed the most significant changes in the levels of tHcy, vWF and HDL-c while patients on VPA showed significant alteration in uric acid, TBARs and GSH.Px. Conclusion: This study supports that in patients with epilepsy, various vascular risk factors and CA-IMT, get worse which could be attributed to epilepsy itself and/or its antiepileptic medications.

Original languageEnglish
Pages (from-to)183-192
Number of pages10
JournalEpilepsy Research
Volume74
Issue number2-3
DOIs
Publication statusPublished - 01-05-2007
Externally publishedYes

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Epilepsy
Atherosclerosis
Oxidative Stress
Carotid Intima-Media Thickness
Thiobarbituric Acid Reactive Substances
Homocysteine
Carotid Arteries
Uric Acid
Malondialdehyde
Fibrinogen
Antioxidants
Common Carotid Artery
Internal Carotid Artery
Glutathione Peroxidase
vascular factor
Anticonvulsants
Blood Vessels
Fasting
Biomarkers
Lipids

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

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abstract = "Purpose: This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. Methods: This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c and LDL-c), total homocysteine (tHcy), von Willbrand factor (vWF), fibrinogen, oxidized LDL (Ox-LDL), malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARs), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GSH.Px), were assessed. Results: Compared to control group, the IMT of patients' common carotid artery, bifurcation area and internal carotid arteries was significantly thickened in 51.1{\%}, 73.3{\%} and 43.6{\%} in various groups of patients (treated and untreated). In the studied patients, the levels of tHcy, vWF, fibrinogen, MDA, TBARs, Ox-LDL levels were increased while HDL-c and TAC were decreased. Patients on CBZ showed the most significant changes in the levels of tHcy, vWF and HDL-c while patients on VPA showed significant alteration in uric acid, TBARs and GSH.Px. Conclusion: This study supports that in patients with epilepsy, various vascular risk factors and CA-IMT, get worse which could be attributed to epilepsy itself and/or its antiepileptic medications.",
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Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy. / Hamed, Sherifa A.; Hamed, Enas A.; Hamdy, Ragaa; Nabeshima, Toshitaka.

In: Epilepsy Research, Vol. 74, No. 2-3, 01.05.2007, p. 183-192.

Research output: Contribution to journalArticle

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