Abstract
Purpose: This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. Methods: This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c and LDL-c), total homocysteine (tHcy), von Willbrand factor (vWF), fibrinogen, oxidized LDL (Ox-LDL), malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARs), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GSH.Px), were assessed. Results: Compared to control group, the IMT of patients' common carotid artery, bifurcation area and internal carotid arteries was significantly thickened in 51.1%, 73.3% and 43.6% in various groups of patients (treated and untreated). In the studied patients, the levels of tHcy, vWF, fibrinogen, MDA, TBARs, Ox-LDL levels were increased while HDL-c and TAC were decreased. Patients on CBZ showed the most significant changes in the levels of tHcy, vWF and HDL-c while patients on VPA showed significant alteration in uric acid, TBARs and GSH.Px. Conclusion: This study supports that in patients with epilepsy, various vascular risk factors and CA-IMT, get worse which could be attributed to epilepsy itself and/or its antiepileptic medications.
| Original language | English |
|---|---|
| Pages (from-to) | 183-192 |
| Number of pages | 10 |
| Journal | Epilepsy Research |
| Volume | 74 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 01-05-2007 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
Cite this
}
Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy. / Hamed, Sherifa A.; Hamed, Enas A.; Hamdy, Ragaa; Nabeshima, Toshitaka.
In: Epilepsy Research, Vol. 74, No. 2-3, 01.05.2007, p. 183-192.Research output: Contribution to journal › Article
TY - JOUR
T1 - Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy
AU - Hamed, Sherifa A.
AU - Hamed, Enas A.
AU - Hamdy, Ragaa
AU - Nabeshima, Toshitaka
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Purpose: This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. Methods: This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c and LDL-c), total homocysteine (tHcy), von Willbrand factor (vWF), fibrinogen, oxidized LDL (Ox-LDL), malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARs), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GSH.Px), were assessed. Results: Compared to control group, the IMT of patients' common carotid artery, bifurcation area and internal carotid arteries was significantly thickened in 51.1%, 73.3% and 43.6% in various groups of patients (treated and untreated). In the studied patients, the levels of tHcy, vWF, fibrinogen, MDA, TBARs, Ox-LDL levels were increased while HDL-c and TAC were decreased. Patients on CBZ showed the most significant changes in the levels of tHcy, vWF and HDL-c while patients on VPA showed significant alteration in uric acid, TBARs and GSH.Px. Conclusion: This study supports that in patients with epilepsy, various vascular risk factors and CA-IMT, get worse which could be attributed to epilepsy itself and/or its antiepileptic medications.
AB - Purpose: This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. Methods: This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c and LDL-c), total homocysteine (tHcy), von Willbrand factor (vWF), fibrinogen, oxidized LDL (Ox-LDL), malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARs), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GSH.Px), were assessed. Results: Compared to control group, the IMT of patients' common carotid artery, bifurcation area and internal carotid arteries was significantly thickened in 51.1%, 73.3% and 43.6% in various groups of patients (treated and untreated). In the studied patients, the levels of tHcy, vWF, fibrinogen, MDA, TBARs, Ox-LDL levels were increased while HDL-c and TAC were decreased. Patients on CBZ showed the most significant changes in the levels of tHcy, vWF and HDL-c while patients on VPA showed significant alteration in uric acid, TBARs and GSH.Px. Conclusion: This study supports that in patients with epilepsy, various vascular risk factors and CA-IMT, get worse which could be attributed to epilepsy itself and/or its antiepileptic medications.
UR - http://www.scopus.com/inward/record.url?scp=34247528209&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247528209&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2007.03.010
DO - 10.1016/j.eplepsyres.2007.03.010
M3 - Article
C2 - 17448640
AN - SCOPUS:34247528209
VL - 74
SP - 183
EP - 192
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 2-3
ER -