Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma

Chisaho Torii; Yasuhiro Hida; Masanobu Shindoh; Kosuke Akiyama; Noritaka Ohga; Nako Maishi; Yoichi Ohiro; Mitsunobu Ono; Yasunori Totsuka; Yoshimasa Kitagawa; Kanchu Tei; Yasufumi Sato; Kyoko Hida

doi:10.21873/anticanres.11437

Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma

Chisaho Torii, Yasuhiro Hida, Masanobu Shindoh, Kosuke Akiyama, Noritaka Ohga, Nako Maishi, Yoichi Ohiro, Mitsunobu Ono, Yasunori Totsuka, Yoshimasa Kitagawa, Kanchu Tei, Yasufumi Sato, Kyoko Hida

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Aim: We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma. Materials and Methods: Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically. Results: VASH1 staining in normal tissue adjacent to cancerous tissue was negative, whereas it was positive in tumour blood vessels and AE1/AE3 and Ki67-positive tumour cells. Therefore, we examined the association between VASH1 expression in the tumour and clinical outcomes. Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression. Conclusion: These results suggest that VASH1 expression is associated with tumour progression and may be useful as a prognostic marker of head and neck squamous cell carcinoma.

Original language	English
Pages (from-to)	1219-1225
Number of pages	7
Journal	Anticancer research
Volume	37
Issue number	3
DOIs	https://doi.org/10.21873/anticanres.11437
Publication status	Published - 03-2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.11437

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title = "Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma",

abstract = "Aim: We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma. Materials and Methods: Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically. Results: VASH1 staining in normal tissue adjacent to cancerous tissue was negative, whereas it was positive in tumour blood vessels and AE1/AE3 and Ki67-positive tumour cells. Therefore, we examined the association between VASH1 expression in the tumour and clinical outcomes. Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression. Conclusion: These results suggest that VASH1 expression is associated with tumour progression and may be useful as a prognostic marker of head and neck squamous cell carcinoma.",

keywords = "Angiogenesis, Head and neck squamous cell carcinoma, Prognosis, Vasohibin-1",

author = "Chisaho Torii and Yasuhiro Hida and Masanobu Shindoh and Kosuke Akiyama and Noritaka Ohga and Nako Maishi and Yoichi Ohiro and Mitsunobu Ono and Yasunori Totsuka and Yoshimasa Kitagawa and Kanchu Tei and Yasufumi Sato and Kyoko Hida",

year = "2017",

month = mar,

doi = "10.21873/anticanres.11437",

language = "English",

volume = "37",

pages = "1219--1225",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma

AU - Torii, Chisaho

AU - Hida, Yasuhiro

AU - Shindoh, Masanobu

AU - Akiyama, Kosuke

AU - Ohga, Noritaka

AU - Maishi, Nako

AU - Ohiro, Yoichi

AU - Ono, Mitsunobu

AU - Totsuka, Yasunori

AU - Kitagawa, Yoshimasa

AU - Tei, Kanchu

AU - Sato, Yasufumi

AU - Hida, Kyoko

PY - 2017/3

Y1 - 2017/3

N2 - Aim: We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma. Materials and Methods: Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically. Results: VASH1 staining in normal tissue adjacent to cancerous tissue was negative, whereas it was positive in tumour blood vessels and AE1/AE3 and Ki67-positive tumour cells. Therefore, we examined the association between VASH1 expression in the tumour and clinical outcomes. Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression. Conclusion: These results suggest that VASH1 expression is associated with tumour progression and may be useful as a prognostic marker of head and neck squamous cell carcinoma.

AB - Aim: We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma. Materials and Methods: Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically. Results: VASH1 staining in normal tissue adjacent to cancerous tissue was negative, whereas it was positive in tumour blood vessels and AE1/AE3 and Ki67-positive tumour cells. Therefore, we examined the association between VASH1 expression in the tumour and clinical outcomes. Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression. Conclusion: These results suggest that VASH1 expression is associated with tumour progression and may be useful as a prognostic marker of head and neck squamous cell carcinoma.

KW - Angiogenesis

KW - Head and neck squamous cell carcinoma

KW - Prognosis

KW - Vasohibin-1

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U2 - 10.21873/anticanres.11437

DO - 10.21873/anticanres.11437

M3 - Article

C2 - 28314285

AN - SCOPUS:85015895460

SN - 0250-7005

VL - 37

SP - 1219

EP - 1225

JO - Anticancer research

JF - Anticancer research

IS - 3

ER -

Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma

Abstract

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