Vasovagal reactions in apheresis donors.

Tadao Tomita, Miyuki Takayanagi, Kimie Kiwada, Akemi Mieda, Chiyoko Takahashi, Tadayoshi Hata

Research output: Contribution to journalComment/debate

32 Citations (Scopus)

Abstract

BACKGROUND: The incidence rate of vasovagal reactions (VVRs) in apheresis is known to be higher in women than in men donors. VVRs in women apheresis donors were therefore analyzed to find out possible factors for their high incidence. STUDY DESIGN AND METHODS: VVR incidence was compared between whole blood (WB) and apheresis donation in relation mainly to age and circulatory blood volume (CBV). In addition, blood pressure and pulse rate were measured during apheresis. RESULTS: In WB donors, the VVR incidence was 0.83 and 1.25 percent, while in apheresis donors it was 0.99 and 4.17 percent in men and women, respectively. The VVR incidence decreased with age in WB donors, but age dependence was very weak in apheresis donors. In elderly women, the incidence increased with repeating cycle of apheresis. There were three different patterns of pulse fluctuation during apheresis, that is, stable (type A), increased rate during blood withdrawal (type B), and irregular pattern (type C). Elderly women donors and donors who suffered from VVRs mostly showed type B fluctuation. There was no particular fluctuation in blood pressure in relation to apheresis cycles. CONCLUSION: The VVR incidence rate was particularly high in women apheresis donors over 45 years old and increased with repeating cycles of apheresis. Smaller CBV, high sensitivity of low-pressure baroreceptors, and citrate effects on cardiovascular reflex might be major factors involved in the high incidence of VVRs.

Original languageEnglish
Pages (from-to)1561-1566
Number of pages6
JournalTransfusion
Volume42
Issue number12
DOIs
Publication statusPublished - 01-01-2002

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Blood Component Removal
Tissue Donors
Incidence
Blood Donors
Blood Volume
Blood Pressure
Pressoreceptors
Citric Acid
Reflex
Heart Rate

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Tomita, T., Takayanagi, M., Kiwada, K., Mieda, A., Takahashi, C., & Hata, T. (2002). Vasovagal reactions in apheresis donors. Transfusion, 42(12), 1561-1566. https://doi.org/10.1046/j.1537-2995.2002.00241.x
Tomita, Tadao ; Takayanagi, Miyuki ; Kiwada, Kimie ; Mieda, Akemi ; Takahashi, Chiyoko ; Hata, Tadayoshi. / Vasovagal reactions in apheresis donors. In: Transfusion. 2002 ; Vol. 42, No. 12. pp. 1561-1566.
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Tomita, T, Takayanagi, M, Kiwada, K, Mieda, A, Takahashi, C & Hata, T 2002, 'Vasovagal reactions in apheresis donors.', Transfusion, vol. 42, no. 12, pp. 1561-1566. https://doi.org/10.1046/j.1537-2995.2002.00241.x

Vasovagal reactions in apheresis donors. / Tomita, Tadao; Takayanagi, Miyuki; Kiwada, Kimie; Mieda, Akemi; Takahashi, Chiyoko; Hata, Tadayoshi.

In: Transfusion, Vol. 42, No. 12, 01.01.2002, p. 1561-1566.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Vasovagal reactions in apheresis donors.

AU - Tomita, Tadao

AU - Takayanagi, Miyuki

AU - Kiwada, Kimie

AU - Mieda, Akemi

AU - Takahashi, Chiyoko

AU - Hata, Tadayoshi

PY - 2002/1/1

Y1 - 2002/1/1

N2 - BACKGROUND: The incidence rate of vasovagal reactions (VVRs) in apheresis is known to be higher in women than in men donors. VVRs in women apheresis donors were therefore analyzed to find out possible factors for their high incidence. STUDY DESIGN AND METHODS: VVR incidence was compared between whole blood (WB) and apheresis donation in relation mainly to age and circulatory blood volume (CBV). In addition, blood pressure and pulse rate were measured during apheresis. RESULTS: In WB donors, the VVR incidence was 0.83 and 1.25 percent, while in apheresis donors it was 0.99 and 4.17 percent in men and women, respectively. The VVR incidence decreased with age in WB donors, but age dependence was very weak in apheresis donors. In elderly women, the incidence increased with repeating cycle of apheresis. There were three different patterns of pulse fluctuation during apheresis, that is, stable (type A), increased rate during blood withdrawal (type B), and irregular pattern (type C). Elderly women donors and donors who suffered from VVRs mostly showed type B fluctuation. There was no particular fluctuation in blood pressure in relation to apheresis cycles. CONCLUSION: The VVR incidence rate was particularly high in women apheresis donors over 45 years old and increased with repeating cycles of apheresis. Smaller CBV, high sensitivity of low-pressure baroreceptors, and citrate effects on cardiovascular reflex might be major factors involved in the high incidence of VVRs.

AB - BACKGROUND: The incidence rate of vasovagal reactions (VVRs) in apheresis is known to be higher in women than in men donors. VVRs in women apheresis donors were therefore analyzed to find out possible factors for their high incidence. STUDY DESIGN AND METHODS: VVR incidence was compared between whole blood (WB) and apheresis donation in relation mainly to age and circulatory blood volume (CBV). In addition, blood pressure and pulse rate were measured during apheresis. RESULTS: In WB donors, the VVR incidence was 0.83 and 1.25 percent, while in apheresis donors it was 0.99 and 4.17 percent in men and women, respectively. The VVR incidence decreased with age in WB donors, but age dependence was very weak in apheresis donors. In elderly women, the incidence increased with repeating cycle of apheresis. There were three different patterns of pulse fluctuation during apheresis, that is, stable (type A), increased rate during blood withdrawal (type B), and irregular pattern (type C). Elderly women donors and donors who suffered from VVRs mostly showed type B fluctuation. There was no particular fluctuation in blood pressure in relation to apheresis cycles. CONCLUSION: The VVR incidence rate was particularly high in women apheresis donors over 45 years old and increased with repeating cycles of apheresis. Smaller CBV, high sensitivity of low-pressure baroreceptors, and citrate effects on cardiovascular reflex might be major factors involved in the high incidence of VVRs.

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U2 - 10.1046/j.1537-2995.2002.00241.x

DO - 10.1046/j.1537-2995.2002.00241.x

M3 - Comment/debate

VL - 42

SP - 1561

EP - 1566

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 12

ER -

Tomita T, Takayanagi M, Kiwada K, Mieda A, Takahashi C, Hata T. Vasovagal reactions in apheresis donors. Transfusion. 2002 Jan 1;42(12):1561-1566. https://doi.org/10.1046/j.1537-2995.2002.00241.x