Veno-occlusive disease of the liver following bone marrow transplantation

A clinical-pathological study of autopsy cases

Kazushige Watanabe, Hiroyuki Iwaki, Masaaki Satoh, Tatsuru Ikeda, Shingo Ichimiya, Nobuhiro Suzuki, Tooru Kudoh, Takanori Oda, Akihiro Matsuura, Michio Mori, Kokichi Kikuchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A total of 28 patients with leukemia underwent intensive therapy with megadose chemotherapy and stem cell transplantation. Of 16 patients who had busulfan therapy, 2 developed the clinical syndrome of veno-occlusive disease of the liver (VOD) characterized by progressive abnormalities in liver function, abdominal pain, and ascites. Postmortem findings showed VOD of the central and sublobular hepatic vein. Immunohistochemical analysis using anti-actin and CD34 mAb was employed in an attempt to clarify the process of fibrosis. Actin positive cells had accumulated around the central vein. Ito cell activation might be responsible for secondary fibrosis following endothelial injury. We report autopsy findings and immunohistochemical results.

Original languageEnglish
Pages (from-to)1145-1150
Number of pages6
JournalArtificial Organs
Volume20
Issue number10
Publication statusPublished - 02-11-1996

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Bone Marrow Transplantation
Liver
Liver Diseases
Actins
Autopsy
Bone
Fibrosis
Busulfan
Hepatic Stellate Cells
Hepatic Veins
Stem Cell Transplantation
Ascites
Abdominal Pain
Veins
Leukemia
Chemotherapy
Stem cells
Drug Therapy
Wounds and Injuries
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Watanabe, K., Iwaki, H., Satoh, M., Ikeda, T., Ichimiya, S., Suzuki, N., ... Kikuchi, K. (1996). Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases. Artificial Organs, 20(10), 1145-1150.
Watanabe, Kazushige ; Iwaki, Hiroyuki ; Satoh, Masaaki ; Ikeda, Tatsuru ; Ichimiya, Shingo ; Suzuki, Nobuhiro ; Kudoh, Tooru ; Oda, Takanori ; Matsuura, Akihiro ; Mori, Michio ; Kikuchi, Kokichi. / Veno-occlusive disease of the liver following bone marrow transplantation : A clinical-pathological study of autopsy cases. In: Artificial Organs. 1996 ; Vol. 20, No. 10. pp. 1145-1150.
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Watanabe, K, Iwaki, H, Satoh, M, Ikeda, T, Ichimiya, S, Suzuki, N, Kudoh, T, Oda, T, Matsuura, A, Mori, M & Kikuchi, K 1996, 'Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases', Artificial Organs, vol. 20, no. 10, pp. 1145-1150.

Veno-occlusive disease of the liver following bone marrow transplantation : A clinical-pathological study of autopsy cases. / Watanabe, Kazushige; Iwaki, Hiroyuki; Satoh, Masaaki; Ikeda, Tatsuru; Ichimiya, Shingo; Suzuki, Nobuhiro; Kudoh, Tooru; Oda, Takanori; Matsuura, Akihiro; Mori, Michio; Kikuchi, Kokichi.

In: Artificial Organs, Vol. 20, No. 10, 02.11.1996, p. 1145-1150.

Research output: Contribution to journalArticle

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AU - Watanabe, Kazushige

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AU - Mori, Michio

AU - Kikuchi, Kokichi

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AB - A total of 28 patients with leukemia underwent intensive therapy with megadose chemotherapy and stem cell transplantation. Of 16 patients who had busulfan therapy, 2 developed the clinical syndrome of veno-occlusive disease of the liver (VOD) characterized by progressive abnormalities in liver function, abdominal pain, and ascites. Postmortem findings showed VOD of the central and sublobular hepatic vein. Immunohistochemical analysis using anti-actin and CD34 mAb was employed in an attempt to clarify the process of fibrosis. Actin positive cells had accumulated around the central vein. Ito cell activation might be responsible for secondary fibrosis following endothelial injury. We report autopsy findings and immunohistochemical results.

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Watanabe K, Iwaki H, Satoh M, Ikeda T, Ichimiya S, Suzuki N et al. Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases. Artificial Organs. 1996 Nov 2;20(10):1145-1150.