Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases

Kazushige Watanabe; Hiroyuki Iwaki; Masaaki Satoh; Tatsuru Ikeda; Shingo Ichimiya; Nobuhiro Suzuki; Tooru Kudoh; Takanori Oda; Akihiro Matsuura; Michio Mori; Kokichi Kikuchi

doi:10.1111/j.1525-1594.1996.tb00652.x

Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases

Kazushige Watanabe, Hiroyuki Iwaki, Masaaki Satoh, Tatsuru Ikeda, Shingo Ichimiya, Nobuhiro Suzuki, Tooru Kudoh, Takanori Oda, Akihiro Matsuura, Michio Mori, Kokichi Kikuchi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A total of 28 patients with leukemia underwent intensive therapy with megadose chemotherapy and stem cell transplantation. Of 16 patients who had busulfan therapy, 2 developed the clinical syndrome of veno-occlusive disease of the liver (VOD) characterized by progressive abnormalities in liver function, abdominal pain, and ascites. Postmortem findings showed VOD of the central and sublobular hepatic vein. Immunohistochemical analysis using anti-actin and CD34 mAb was employed in an attempt to clarify the process of fibrosis. Actin positive cells had accumulated around the central vein. Ito cell activation might be responsible for secondary fibrosis following endothelial injury. We report autopsy findings and immunohistochemical results.

Original language	English
Pages (from-to)	1145-1150
Number of pages	6
Journal	Artificial Organs
Volume	20
Issue number	10
DOIs	https://doi.org/10.1111/j.1525-1594.1996.tb00652.x
Publication status	Published - 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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10.1111/j.1525-1594.1996.tb00652.x

Cite this

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title = "Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases",

abstract = "A total of 28 patients with leukemia underwent intensive therapy with megadose chemotherapy and stem cell transplantation. Of 16 patients who had busulfan therapy, 2 developed the clinical syndrome of veno-occlusive disease of the liver (VOD) characterized by progressive abnormalities in liver function, abdominal pain, and ascites. Postmortem findings showed VOD of the central and sublobular hepatic vein. Immunohistochemical analysis using anti-actin and CD34 mAb was employed in an attempt to clarify the process of fibrosis. Actin positive cells had accumulated around the central vein. Ito cell activation might be responsible for secondary fibrosis following endothelial injury. We report autopsy findings and immunohistochemical results.",

author = "Kazushige Watanabe and Hiroyuki Iwaki and Masaaki Satoh and Tatsuru Ikeda and Shingo Ichimiya and Nobuhiro Suzuki and Tooru Kudoh and Takanori Oda and Akihiro Matsuura and Michio Mori and Kokichi Kikuchi",

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language = "English",

volume = "20",

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TY - JOUR

T1 - Veno-occlusive disease of the liver following bone marrow transplantation

T2 - A clinical-pathological study of autopsy cases

AU - Watanabe, Kazushige

AU - Iwaki, Hiroyuki

AU - Satoh, Masaaki

AU - Ikeda, Tatsuru

AU - Ichimiya, Shingo

AU - Suzuki, Nobuhiro

AU - Kudoh, Tooru

AU - Oda, Takanori

AU - Matsuura, Akihiro

AU - Mori, Michio

AU - Kikuchi, Kokichi

PY - 1996

Y1 - 1996

N2 - A total of 28 patients with leukemia underwent intensive therapy with megadose chemotherapy and stem cell transplantation. Of 16 patients who had busulfan therapy, 2 developed the clinical syndrome of veno-occlusive disease of the liver (VOD) characterized by progressive abnormalities in liver function, abdominal pain, and ascites. Postmortem findings showed VOD of the central and sublobular hepatic vein. Immunohistochemical analysis using anti-actin and CD34 mAb was employed in an attempt to clarify the process of fibrosis. Actin positive cells had accumulated around the central vein. Ito cell activation might be responsible for secondary fibrosis following endothelial injury. We report autopsy findings and immunohistochemical results.

AB - A total of 28 patients with leukemia underwent intensive therapy with megadose chemotherapy and stem cell transplantation. Of 16 patients who had busulfan therapy, 2 developed the clinical syndrome of veno-occlusive disease of the liver (VOD) characterized by progressive abnormalities in liver function, abdominal pain, and ascites. Postmortem findings showed VOD of the central and sublobular hepatic vein. Immunohistochemical analysis using anti-actin and CD34 mAb was employed in an attempt to clarify the process of fibrosis. Actin positive cells had accumulated around the central vein. Ito cell activation might be responsible for secondary fibrosis following endothelial injury. We report autopsy findings and immunohistochemical results.

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Veno-occlusive disease of the liver following bone marrow transplantation: A clinical-pathological study of autopsy cases

Abstract

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