Ventricular Repolarization Instability in Patients with a Malignant Form of Ventricular Extrasystoles Originating from the Right Ventricular Outflow Tract

Tomohide Ichikawa, Eiichi Watanabe, Yoshihiro Sobue, Mayumi Yamamoto, Hiroto Harigaya, Kentaro Okuda, Atsushi Kani, Kazuo Kato, Yukio Ozaki

Research output: Contribution to journalArticle

Abstract

Objective: Ventricular extrasystoles (VEs) originating from the right ventricular outflow tract (RVOT) are considered benign, but sometimes lead to sudden cardiac death due to polymorphic ventricular tachycardia or ventricular fibrillation (PVT/VF). Previous case reports suggested that patients with a malignant form of RVOT-VE exhibited a left bundle-branch block morphology and positive deflection in lead I. We assessed the hypothesis that patients with a malignant form of RVOT-VE may have ventricular repolarization instability. Methods and Results: We studied 3 patients with a malignant form of RVOT-VE (age, 34 ± 17 years, 2 males) and compared them to 40 control subjects without structural heart disease. All patients underwent high-resolution digital Holter recording (ela medical) and we determined the maximum value of the beat-to-beat T-wave variability (TAV). The patients with a malignant form of RVOT-VE had a higher maximum value of the TAV than the controls (max TAV: 69 ± 9 μV vs. 20 ± 7 μV, p<0.001). During the follow-up, two males experienced shock deliveries for VF by an implantable cardioverter-defibrillator (ICD). The remaining one female had survived after a radiofrequency Catheter ablation and no ICD was implanted. Conclusions: Our results suggest that patients with a malignant form of RVOT-VE may have a ventricular repolarization instability.

Original languageEnglish
Number of pages1
Journaljournal of arrhythmia
Volume27
DOIs
Publication statusPublished - 01-01-2011

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Ventricular Repolarization Instability in Patients with a Malignant Form of Ventricular Extrasystoles Originating from the Right Ventricular Outflow Tract'. Together they form a unique fingerprint.

  • Cite this