Verbal memory impairment in patients with subsyndromal bipolar disorder

Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Backgrounds: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i.e., with or without a category structure) affects severity of verbal memory deficits in patients with subsyndromal bipolar disorder. Methods: Thirty-six patients with bipolar disorder with mild symptoms and 42 healthy volunteers participated in the study. We first compared effect sizes for memory deficits in patients among the CVLT-II, Brief Assessment of Cognition in Schizophrenia (BACS), and Hopkins Verbal Memory Tests-Revised (HVLT-R). We next evaluated the correlations between scores of the CVLT-II vs. those of the BACS and HVLT-R. Bipolar patients were re-assessed with the same (standard) or alternate forms of the CVLT-II and HVLT-R 1 month later. Results: Scores on the CVLT-II 1-5 Free Recall and Long-delay Free Recall, as well as the HVLT-R Immediate Recall, but not the BACS List Learning were significantly lower for patients compared to control subjects. The effect sizes for cognitive decline due to the illness were comparable when measured by the CVLT-II and HVLT-R, ranging from 0.5 to 0.6. CVLT-II scores were significantly correlated with those of the HVLT-R and BACS. Test-retest reliability of the CVLT-II was acceptable, and no significant practice effect was observed when the alternate form was used. There was no consistent relationship between mood symptoms and performance on the CVLT-II. Conclusion: These results suggest the CVLT-II Japanese version is able to discriminate between bipolar disorder patients and healthy controls with good sensitivity and validity. Data in this study also indicate that the degree of verbal memory deficits in bipolar disorder may be influenced by memory organizational strategy.

Original languageEnglish
Article number168
JournalFrontiers in Psychiatry
Volume8
Issue numberSEP
DOIs
Publication statusPublished - 15-09-2017

Fingerprint

Verbal Learning
Bipolar Disorder
Cognition
Schizophrenia
Memory Disorders
Learning
Reproducibility of Results
Executive Function
Mood Disorders
Short-Term Memory
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Sumiyoshi, T., Toyomaki, A., Kawano, N., Kitajima, T., Kusumi, I., Ozaki, N., ... Nakagome, K. (2017). Verbal memory impairment in patients with subsyndromal bipolar disorder. Frontiers in Psychiatry, 8(SEP), [168]. https://doi.org/10.3389/fpsyt.2017.00168
Sumiyoshi, Tomiki ; Toyomaki, Atsuhito ; Kawano, Naoko ; Kitajima, Tomoko ; Kusumi, Ichiro ; Ozaki, Norio ; Iwata, Nakao ; Sueyoshi, Kazuki ; Nakagome, Kazuyuki. / Verbal memory impairment in patients with subsyndromal bipolar disorder. In: Frontiers in Psychiatry. 2017 ; Vol. 8, No. SEP.
@article{6387b66a457e473194eaac9dd5952607,
title = "Verbal memory impairment in patients with subsyndromal bipolar disorder",
abstract = "Backgrounds: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i.e., with or without a category structure) affects severity of verbal memory deficits in patients with subsyndromal bipolar disorder. Methods: Thirty-six patients with bipolar disorder with mild symptoms and 42 healthy volunteers participated in the study. We first compared effect sizes for memory deficits in patients among the CVLT-II, Brief Assessment of Cognition in Schizophrenia (BACS), and Hopkins Verbal Memory Tests-Revised (HVLT-R). We next evaluated the correlations between scores of the CVLT-II vs. those of the BACS and HVLT-R. Bipolar patients were re-assessed with the same (standard) or alternate forms of the CVLT-II and HVLT-R 1 month later. Results: Scores on the CVLT-II 1-5 Free Recall and Long-delay Free Recall, as well as the HVLT-R Immediate Recall, but not the BACS List Learning were significantly lower for patients compared to control subjects. The effect sizes for cognitive decline due to the illness were comparable when measured by the CVLT-II and HVLT-R, ranging from 0.5 to 0.6. CVLT-II scores were significantly correlated with those of the HVLT-R and BACS. Test-retest reliability of the CVLT-II was acceptable, and no significant practice effect was observed when the alternate form was used. There was no consistent relationship between mood symptoms and performance on the CVLT-II. Conclusion: These results suggest the CVLT-II Japanese version is able to discriminate between bipolar disorder patients and healthy controls with good sensitivity and validity. Data in this study also indicate that the degree of verbal memory deficits in bipolar disorder may be influenced by memory organizational strategy.",
author = "Tomiki Sumiyoshi and Atsuhito Toyomaki and Naoko Kawano and Tomoko Kitajima and Ichiro Kusumi and Norio Ozaki and Nakao Iwata and Kazuki Sueyoshi and Kazuyuki Nakagome",
year = "2017",
month = "9",
day = "15",
doi = "10.3389/fpsyt.2017.00168",
language = "English",
volume = "8",
journal = "Frontiers in Psychiatry",
issn = "1664-0640",
publisher = "Frontiers Research Foundation",
number = "SEP",

}

Sumiyoshi, T, Toyomaki, A, Kawano, N, Kitajima, T, Kusumi, I, Ozaki, N, Iwata, N, Sueyoshi, K & Nakagome, K 2017, 'Verbal memory impairment in patients with subsyndromal bipolar disorder', Frontiers in Psychiatry, vol. 8, no. SEP, 168. https://doi.org/10.3389/fpsyt.2017.00168

Verbal memory impairment in patients with subsyndromal bipolar disorder. / Sumiyoshi, Tomiki; Toyomaki, Atsuhito; Kawano, Naoko; Kitajima, Tomoko; Kusumi, Ichiro; Ozaki, Norio; Iwata, Nakao; Sueyoshi, Kazuki; Nakagome, Kazuyuki.

In: Frontiers in Psychiatry, Vol. 8, No. SEP, 168, 15.09.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Verbal memory impairment in patients with subsyndromal bipolar disorder

AU - Sumiyoshi, Tomiki

AU - Toyomaki, Atsuhito

AU - Kawano, Naoko

AU - Kitajima, Tomoko

AU - Kusumi, Ichiro

AU - Ozaki, Norio

AU - Iwata, Nakao

AU - Sueyoshi, Kazuki

AU - Nakagome, Kazuyuki

PY - 2017/9/15

Y1 - 2017/9/15

N2 - Backgrounds: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i.e., with or without a category structure) affects severity of verbal memory deficits in patients with subsyndromal bipolar disorder. Methods: Thirty-six patients with bipolar disorder with mild symptoms and 42 healthy volunteers participated in the study. We first compared effect sizes for memory deficits in patients among the CVLT-II, Brief Assessment of Cognition in Schizophrenia (BACS), and Hopkins Verbal Memory Tests-Revised (HVLT-R). We next evaluated the correlations between scores of the CVLT-II vs. those of the BACS and HVLT-R. Bipolar patients were re-assessed with the same (standard) or alternate forms of the CVLT-II and HVLT-R 1 month later. Results: Scores on the CVLT-II 1-5 Free Recall and Long-delay Free Recall, as well as the HVLT-R Immediate Recall, but not the BACS List Learning were significantly lower for patients compared to control subjects. The effect sizes for cognitive decline due to the illness were comparable when measured by the CVLT-II and HVLT-R, ranging from 0.5 to 0.6. CVLT-II scores were significantly correlated with those of the HVLT-R and BACS. Test-retest reliability of the CVLT-II was acceptable, and no significant practice effect was observed when the alternate form was used. There was no consistent relationship between mood symptoms and performance on the CVLT-II. Conclusion: These results suggest the CVLT-II Japanese version is able to discriminate between bipolar disorder patients and healthy controls with good sensitivity and validity. Data in this study also indicate that the degree of verbal memory deficits in bipolar disorder may be influenced by memory organizational strategy.

AB - Backgrounds: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i.e., with or without a category structure) affects severity of verbal memory deficits in patients with subsyndromal bipolar disorder. Methods: Thirty-six patients with bipolar disorder with mild symptoms and 42 healthy volunteers participated in the study. We first compared effect sizes for memory deficits in patients among the CVLT-II, Brief Assessment of Cognition in Schizophrenia (BACS), and Hopkins Verbal Memory Tests-Revised (HVLT-R). We next evaluated the correlations between scores of the CVLT-II vs. those of the BACS and HVLT-R. Bipolar patients were re-assessed with the same (standard) or alternate forms of the CVLT-II and HVLT-R 1 month later. Results: Scores on the CVLT-II 1-5 Free Recall and Long-delay Free Recall, as well as the HVLT-R Immediate Recall, but not the BACS List Learning were significantly lower for patients compared to control subjects. The effect sizes for cognitive decline due to the illness were comparable when measured by the CVLT-II and HVLT-R, ranging from 0.5 to 0.6. CVLT-II scores were significantly correlated with those of the HVLT-R and BACS. Test-retest reliability of the CVLT-II was acceptable, and no significant practice effect was observed when the alternate form was used. There was no consistent relationship between mood symptoms and performance on the CVLT-II. Conclusion: These results suggest the CVLT-II Japanese version is able to discriminate between bipolar disorder patients and healthy controls with good sensitivity and validity. Data in this study also indicate that the degree of verbal memory deficits in bipolar disorder may be influenced by memory organizational strategy.

UR - http://www.scopus.com/inward/record.url?scp=85029700362&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029700362&partnerID=8YFLogxK

U2 - 10.3389/fpsyt.2017.00168

DO - 10.3389/fpsyt.2017.00168

M3 - Article

VL - 8

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

IS - SEP

M1 - 168

ER -

Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N et al. Verbal memory impairment in patients with subsyndromal bipolar disorder. Frontiers in Psychiatry. 2017 Sep 15;8(SEP). 168. https://doi.org/10.3389/fpsyt.2017.00168