Vestibular compensation after unilateral labyrinthectomy in mice

Norihiko Murai; Jun Tsuji; Ryusuke Hori; Kazuo Funabiki; Yasushi Naito; Takayuki Nakagawa; Juichi Ito

doi:10.3757/jser.61.40

Vestibular compensation after unilateral labyrinthectomy in mice

Norihiko Murai, Jun Tsuji, Ryusuke Hori, Kazuo Funabiki, Yasushi Naito, Takayuki Nakagawa, Juichi Ito

Research output: Contribution to journal › Article › peer-review

Abstract

Vestibular compensation after unilateral labyrinthectomy (UL) in mice was investigated by measuring the gain of horizontal vestibulo-ocular reflex (HVOR) with an infrared system. Six C57BL/6 mice underwent unilateral labyrinthectomy by injection of ethanol into the semicircular canal. Before UL, HVOR gain under sinusoidal rotation with a maximal head velocity (HVmax) of 40 deg/sec and a frequency range between 0.1 and 3.2 Hz was analyzed. Before and after UL, gain of HVOR under sinusoidal rotation with an HVmax of 150 deg/sec and a frequency of 1.6 Hz was analyzed. After UL, HVOR gain decreased showing a minimal value of 21% of preoperative value on the second postoperative day, then recovered to 65% of the preoperative value by the 28th postoperative day. These results provide fundamental data as a reference for future studies on vestibular compensation in genetically-manipulated mice.

Original language	English
Pages (from-to)	40-44
Number of pages	5
Journal	Equilibrium Research
Volume	61
Issue number	1
DOIs	https://doi.org/10.3757/jser.61.40
Publication status	Published - 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Otorhinolaryngology
Clinical Neurology

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title = "Vestibular compensation after unilateral labyrinthectomy in mice",

abstract = "Vestibular compensation after unilateral labyrinthectomy (UL) in mice was investigated by measuring the gain of horizontal vestibulo-ocular reflex (HVOR) with an infrared system. Six C57BL/6 mice underwent unilateral labyrinthectomy by injection of ethanol into the semicircular canal. Before UL, HVOR gain under sinusoidal rotation with a maximal head velocity (HVmax) of 40 deg/sec and a frequency range between 0.1 and 3.2 Hz was analyzed. Before and after UL, gain of HVOR under sinusoidal rotation with an HVmax of 150 deg/sec and a frequency of 1.6 Hz was analyzed. After UL, HVOR gain decreased showing a minimal value of 21% of preoperative value on the second postoperative day, then recovered to 65% of the preoperative value by the 28th postoperative day. These results provide fundamental data as a reference for future studies on vestibular compensation in genetically-manipulated mice.",

author = "Norihiko Murai and Jun Tsuji and Ryusuke Hori and Kazuo Funabiki and Yasushi Naito and Takayuki Nakagawa and Juichi Ito",

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AU - Murai, Norihiko

AU - Tsuji, Jun

AU - Hori, Ryusuke

AU - Funabiki, Kazuo

AU - Naito, Yasushi

AU - Nakagawa, Takayuki

AU - Ito, Juichi

PY - 2002

Y1 - 2002

N2 - Vestibular compensation after unilateral labyrinthectomy (UL) in mice was investigated by measuring the gain of horizontal vestibulo-ocular reflex (HVOR) with an infrared system. Six C57BL/6 mice underwent unilateral labyrinthectomy by injection of ethanol into the semicircular canal. Before UL, HVOR gain under sinusoidal rotation with a maximal head velocity (HVmax) of 40 deg/sec and a frequency range between 0.1 and 3.2 Hz was analyzed. Before and after UL, gain of HVOR under sinusoidal rotation with an HVmax of 150 deg/sec and a frequency of 1.6 Hz was analyzed. After UL, HVOR gain decreased showing a minimal value of 21% of preoperative value on the second postoperative day, then recovered to 65% of the preoperative value by the 28th postoperative day. These results provide fundamental data as a reference for future studies on vestibular compensation in genetically-manipulated mice.

AB - Vestibular compensation after unilateral labyrinthectomy (UL) in mice was investigated by measuring the gain of horizontal vestibulo-ocular reflex (HVOR) with an infrared system. Six C57BL/6 mice underwent unilateral labyrinthectomy by injection of ethanol into the semicircular canal. Before UL, HVOR gain under sinusoidal rotation with a maximal head velocity (HVmax) of 40 deg/sec and a frequency range between 0.1 and 3.2 Hz was analyzed. Before and after UL, gain of HVOR under sinusoidal rotation with an HVmax of 150 deg/sec and a frequency of 1.6 Hz was analyzed. After UL, HVOR gain decreased showing a minimal value of 21% of preoperative value on the second postoperative day, then recovered to 65% of the preoperative value by the 28th postoperative day. These results provide fundamental data as a reference for future studies on vestibular compensation in genetically-manipulated mice.

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Vestibular compensation after unilateral labyrinthectomy in mice

Abstract

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