Viral DNA Loads in Various Blood Components of Patients with Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases

Jun Ichi Kawada; Yasuko Kamiya; Akihisa Sawada; Keiji Iwatsuki; Koji Izutsu; Yuka Torii; Hiroshi Kimura; Yoshinori Ito

doi:10.1093/infdis/jiz315

Viral DNA Loads in Various Blood Components of Patients with Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases

Jun Ichi Kawada, Yasuko Kamiya, Akihisa Sawada, Keiji Iwatsuki, Koji Izutsu, Yuka Torii, Hiroshi Kimura, Yoshinori Ito

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in "active" disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 10^4.2 (15 800) IU/mL.

Original language	English
Pages (from-to)	1307-1311
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	220
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiz315
Publication status	Published - 13-09-2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiz315

Cite this

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abstract = "To evaluate diagnostic values for Epstein-Barr virus (EBV) DNA loads in different blood components of patients with EBV-positive T-cell/natural killer cell lymphoproliferative diseases, EBV DNA loads were compared among disease categories in each blood component from 59 patients. Plasma viral loads were significantly higher in {"}active{"} disease in chronic active EBV infection. EBV DNA was not detected in the plasma from 7 patients in whom EBV DNA was detected in peripheral blood mononuclear cells and whole blood. Diagnostic cutoff values for whole blood EBV DNA loads of patients with chronic active EBV infection compared with those of infectious mononucleosis was 104.2 (15 800) IU/mL.",

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AU - Kawada, Jun Ichi

AU - Kamiya, Yasuko

AU - Sawada, Akihisa

AU - Iwatsuki, Keiji

AU - Izutsu, Koji

AU - Torii, Yuka

AU - Kimura, Hiroshi

AU - Ito, Yoshinori

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Viral DNA Loads in Various Blood Components of Patients with Epstein-Barr Virus-Positive T-Cell/Natural Killer Cell Lymphoproliferative Diseases

Abstract

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UN SDGs

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