Viremia and neutralizing antibody response in infants with exanthem subitum

Yoshizo Asano, Tetsushi Yoshikawa, Sadao Suga, Takehiko Yazaki, Tadayoshi Hata, Takao Nagai, Yuji Kajita, Takao Ozaki, Shigeru Yoshida

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66%) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100% (26/26) on days 0 to 2 (just before appearance of skin rash), 82% (9/11) on day 3,20% (2/10) on day 4,7% (2/12) on days 5 to 7, and 0% (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21%) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18% (2/11). It became 60% (6/10) on day 4, 75% (9/12) on days 5 to 7, and 100% on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalThe Journal of Pediatrics
Volume114
Issue number4 PART 1
DOIs
Publication statusPublished - 04-1989

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Viremia and neutralizing antibody response in infants with exanthem subitum'. Together they form a unique fingerprint.

  • Cite this

    Asano, Y., Yoshikawa, T., Suga, S., Yazaki, T., Hata, T., Nagai, T., Kajita, Y., Ozaki, T., & Yoshida, S. (1989). Viremia and neutralizing antibody response in infants with exanthem subitum. The Journal of Pediatrics, 114(4 PART 1), 535-539. https://doi.org/10.1016/S0022-3476(89)80689-4