Viremia and neutralizing antibody response in infants with exanthem subitum

Yoshizo Asano, Tetsushi Yoshikawa, Sadao Suga, Takehiko Yazaki, Tadayoshi Hata, Takao Nagai, Yuji Kajita, Takao Ozaki, Shigeru Yoshida

Research output: Contribution to journalArticle

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Abstract

Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66%) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100% (26/26) on days 0 to 2 (just before appearance of skin rash), 82% (9/11) on day 3,20% (2/10) on day 4,7% (2/12) on days 5 to 7, and 0% (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21%) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18% (2/11). It became 60% (6/10) on day 4, 75% (9/12) on days 5 to 7, and 100% on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalThe Journal of Pediatrics
Volume114
Issue number4 PART 1
DOIs
Publication statusPublished - 01-01-1989

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Viremia
Exanthema
Neutralizing Antibodies
Antibody Formation
Viruses
Human Herpesvirus 6
Cell Separation
Immunity
Antibodies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Asano, Yoshizo ; Yoshikawa, Tetsushi ; Suga, Sadao ; Yazaki, Takehiko ; Hata, Tadayoshi ; Nagai, Takao ; Kajita, Yuji ; Ozaki, Takao ; Yoshida, Shigeru. / Viremia and neutralizing antibody response in infants with exanthem subitum. In: The Journal of Pediatrics. 1989 ; Vol. 114, No. 4 PART 1. pp. 535-539.
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abstract = "Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66{\%}) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100{\%} (26/26) on days 0 to 2 (just before appearance of skin rash), 82{\%} (9/11) on day 3,20{\%} (2/10) on day 4,7{\%} (2/12) on days 5 to 7, and 0{\%} (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21{\%}) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18{\%} (2/11). It became 60{\%} (6/10) on day 4, 75{\%} (9/12) on days 5 to 7, and 100{\%} on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.",
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Asano, Y, Yoshikawa, T, Suga, S, Yazaki, T, Hata, T, Nagai, T, Kajita, Y, Ozaki, T & Yoshida, S 1989, 'Viremia and neutralizing antibody response in infants with exanthem subitum', The Journal of Pediatrics, vol. 114, no. 4 PART 1, pp. 535-539. https://doi.org/10.1016/S0022-3476(89)80689-4

Viremia and neutralizing antibody response in infants with exanthem subitum. / Asano, Yoshizo; Yoshikawa, Tetsushi; Suga, Sadao; Yazaki, Takehiko; Hata, Tadayoshi; Nagai, Takao; Kajita, Yuji; Ozaki, Takao; Yoshida, Shigeru.

In: The Journal of Pediatrics, Vol. 114, No. 4 PART 1, 01.01.1989, p. 535-539.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

AU - Suga, Sadao

AU - Yazaki, Takehiko

AU - Hata, Tadayoshi

AU - Nagai, Takao

AU - Kajita, Yuji

AU - Ozaki, Takao

AU - Yoshida, Shigeru

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N2 - Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66%) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100% (26/26) on days 0 to 2 (just before appearance of skin rash), 82% (9/11) on day 3,20% (2/10) on day 4,7% (2/12) on days 5 to 7, and 0% (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21%) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18% (2/11). It became 60% (6/10) on day 4, 75% (9/12) on days 5 to 7, and 100% on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.

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