Viremia and neutralizing antibody response in infants with exanthem subitum

Yoshizo Asano, Tetsushi Yoshikawa, Sadao Suga, Takehiko Yazaki, Tadayoshi Hata, Takao Nagai, Yuji Kajita, Takao Ozaki, Shigeru Yoshida

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)


Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66%) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100% (26/26) on days 0 to 2 (just before appearance of skin rash), 82% (9/11) on day 3,20% (2/10) on day 4,7% (2/12) on days 5 to 7, and 0% (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21%) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18% (2/11). It became 60% (6/10) on day 4, 75% (9/12) on days 5 to 7, and 100% on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalThe Journal of Pediatrics
Issue number4 PART 1
Publication statusPublished - 04-1989

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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