Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders

Toshiki Mano, Katumi Iwase, Ritsuko Hayashi, Nobuki Hayakawa, Keiko Uchimura, Masaki Makino, Mutsuko Nagata, Yosikuni Sawai, Naohisa Oda, Michiko Hamada, Toshihiro Aono, Akira Nakai, Akio Nagasaka, Mitsuyasu Itoh

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of α-, β-, and γ- tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of α-tocopherols and γ-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of γ-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.

Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume315
Issue number4
DOIs
Publication statusPublished - 01-01-1998

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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