Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders

Toshiki Mano; Katumi Iwase; Ritsuko Hayashi; Nobuki Hayakawa; Keiko Uchimura; Masaki Makino; Mutsuko Nagata; Yosikuni Sawai; Naohisa Oda; Michiko Hamada; Toshihiro Aono; Akira Nakai; Akio Nagasaka; Mitsuyasu Itoh

doi:10.1016/s0002-9629(15)40317-9

Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders

Toshiki Mano, Katumi Iwase, Ritsuko Hayashi, Nobuki Hayakawa, Keiko Uchimura, Masaki Makino, Mutsuko Nagata, Yosikuni Sawai, Naohisa Oda, Michiko Hamada, Toshihiro Aono, Akira Nakai, Akio Nagasaka, Mitsuyasu Itoh

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of α-, β-, and γ- tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of α-tocopherols and γ-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of γ-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.

Original language	English
Pages (from-to)	230-232
Number of pages	3
Journal	American Journal of the Medical Sciences
Volume	315
Issue number	4
DOIs	https://doi.org/10.1016/s0002-9629(15)40317-9
Publication status	Published - 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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10.1016/s0002-9629(15)40317-9

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Mano, T., Iwase, K., Hayashi, R., Hayakawa, N., Uchimura, K., Makino, M., Nagata, M., Sawai, Y., Oda, N., Hamada, M., Aono, T., Nakai, A., Nagasaka, A., & Itoh, M. (1998). Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders. American Journal of the Medical Sciences, 315(4), 230-232. https://doi.org/10.1016/s0002-9629(15)40317-9

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title = "Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders",

abstract = "To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of α-, β-, and γ- tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of α-tocopherols and γ-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of γ-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.",

keywords = "Coenzyme Q, Hyperthyroidism, Thyroid cancer, Vitamin E",

author = "Toshiki Mano and Katumi Iwase and Ritsuko Hayashi and Nobuki Hayakawa and Keiko Uchimura and Masaki Makino and Mutsuko Nagata and Yosikuni Sawai and Naohisa Oda and Michiko Hamada and Toshihiro Aono and Akira Nakai and Akio Nagasaka and Mitsuyasu Itoh",

year = "1998",

doi = "10.1016/s0002-9629(15)40317-9",

language = "English",

volume = "315",

pages = "230--232",

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Mano, T, Iwase, K, Hayashi, R, Hayakawa, N, Uchimura, K, Makino, M, Nagata, M, Sawai, Y, Oda, N, Hamada, M, Aono, T, Nakai, A, Nagasaka, A & Itoh, M 1998, 'Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders', American Journal of the Medical Sciences, vol. 315, no. 4, pp. 230-232. https://doi.org/10.1016/s0002-9629(15)40317-9

TY - JOUR

T1 - Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders

AU - Mano, Toshiki

AU - Iwase, Katumi

AU - Hayashi, Ritsuko

AU - Hayakawa, Nobuki

AU - Uchimura, Keiko

AU - Makino, Masaki

AU - Nagata, Mutsuko

AU - Sawai, Yosikuni

AU - Oda, Naohisa

AU - Hamada, Michiko

AU - Aono, Toshihiro

AU - Nakai, Akira

AU - Nagasaka, Akio

AU - Itoh, Mitsuyasu

PY - 1998

Y1 - 1998

N2 - To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of α-, β-, and γ- tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of α-tocopherols and γ-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of γ-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.

AB - To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of α-, β-, and γ- tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of α-tocopherols and γ-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of γ-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.

KW - Coenzyme Q

KW - Hyperthyroidism

KW - Thyroid cancer

KW - Vitamin E

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U2 - 10.1016/s0002-9629(15)40317-9

DO - 10.1016/s0002-9629(15)40317-9

M3 - Article

C2 - 9537635

AN - SCOPUS:0031978966

SN - 0002-9629

VL - 315

SP - 230

EP - 232

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

IS - 4

ER -

Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders

Abstract

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