Volumetric analysis of coronary plaque characterization in patients with metabolic syndrome using 64-slice multi-detector computed tomography

Kosuke Arai, Hideki Ishii, Tetsuya Amano, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Kiminobu Yokoi, Hirohiko Ando, Soichiro Kumagai, Ken Harada, Daiji Yoshikawa, Satoru Ohshima, Tatsuaki Matsubara, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Metabolic syndrome (MetS) is associated with adverse cardiovascular events and mortality, where acute coronary syndrome significantly impacts on mortality and morbidity. In contrast, evidences have accumulated that the lipid-rich plaque might play a critical role in acute coronary syndrome. Methods and Results: The study population consisted of 94 patients with suspected angina pectoris who underwent multi-detector computed tomography (MDCT). Of those, we identified 41 with MetS. In MDCT analysis, low-density plaque volume (LDPV) (42±28 vs 24±18 mm3, P=0.0003), moderate-density plaque volume (105±41 vs 82±33 mm3, P=0.003), total plaque volume (164±70 vs 118±59 mm3, P=0.0008) and %LDPV (24.2±10.0 vs 18.3±7.1%, P=0.01) were significantly increased in the MetS group compared to the non-MetS group. Multivariate linear regression analysis after adjusting for confounding variables revealed that MetS was significantly correlated with an increase in %LDPV (β=0.48, P=0.0001). Multivariate logistic regression analysis for lipid-rich plaque after adjusting for confounding variables indicated that MetS was significantly associated with lipid-rich plaque (odds ratio: 5.99, 95% confidence intervals: 1.94-18.6, P=0.002). Conclusions: Patients with MetS were strongly related to having a lipid-rich composition in their coronary plaque, as detected by MDCT.

Original languageEnglish
Pages (from-to)2146-2151
Number of pages6
JournalCirculation Journal
Volume74
Issue number10
DOIs
Publication statusPublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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