Vomeroglandin/CRP-ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: Identification and characterization of mouse vomeroglandin

Fumio Matsushita, Atsushi Miyawaki, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain. This domain arrangement is similar to those of rat Ebnerin, human DMBT1, and rabbit hensin. In situ hybridization analysis shows strong expression of vomeroglandin mRNA in the glands of vomeronasal system. Immunological analyses detect both membrane-bound and secreted forms of vomeroglandin. The secreted protein seems to be localized in the lumen of the vomeronasal organ, playing a certain role in the pheromone perception. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume268
Issue number2
DOIs
Publication statusPublished - 16-02-2000

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Vomeronasal Organ
Scavenger Receptors
Proteins
Pheromones
In Situ Hybridization
Cysteine
Rats
Rabbits
Membranes
Messenger RNA
Mouse Dmbt1 protein
ductin

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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AB - Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain. This domain arrangement is similar to those of rat Ebnerin, human DMBT1, and rabbit hensin. In situ hybridization analysis shows strong expression of vomeroglandin mRNA in the glands of vomeronasal system. Immunological analyses detect both membrane-bound and secreted forms of vomeroglandin. The secreted protein seems to be localized in the lumen of the vomeronasal organ, playing a certain role in the pheromone perception. (C) 2000 Academic Press.

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