Voriconazole-responsive disseminated nodular lesions on spinal MRI

Seiko Hirota, Shinji Ito, Takao Fukui, Kenichiro Murate, Sayuri Shima, Madoka Kizawa, Akihiro Ueda, Kunihiko Asakura, Tatsuro Mutoh

Research output: Contribution to journalArticle

Abstract

A 74-year-old woman was hospitalized due to dysuria, weakness and dysesthesia of the lower extremities. She was in an immunosuppressed state following the administration of methylprednisolone therapy for idiopathic interstitial pneumonia. Cerebrospinal fluid and blood cultures were negative, and no infectious biomarkers were found. A gadolinium (Gd)-enhanced T1-weighted image of magnetic resonance imaging (MRI) revealed disseminated nodular lesions along the spinal cord. We suspected a diagnosis of seronegative deep mycosis and initiated anti-fungal therapy with voriconazole, which subsequently alleviated all of the patient’s symptoms and MRI findings. Therefore, the presence of Gd-enhanced disseminated nodules on spinal MRI may be a good marker of deep meningeal mycosis.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalInternal Medicine
Volume54
Issue number2
DOIs
Publication statusPublished - 01-01-2015

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Mycoses
Magnetic Resonance Imaging
Gadolinium
Idiopathic Interstitial Pneumonias
Dysuria
Paresthesia
Methylprednisolone
Cerebrospinal Fluid
Lower Extremity
Spinal Cord
Biomarkers
Therapeutics
Voriconazole
Blood Culture

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Hirota, S., Ito, S., Fukui, T., Murate, K., Shima, S., Kizawa, M., ... Mutoh, T. (2015). Voriconazole-responsive disseminated nodular lesions on spinal MRI. Internal Medicine, 54(2), 215-218. https://doi.org/10.2169/internalmedicine.54.3148
Hirota, Seiko ; Ito, Shinji ; Fukui, Takao ; Murate, Kenichiro ; Shima, Sayuri ; Kizawa, Madoka ; Ueda, Akihiro ; Asakura, Kunihiko ; Mutoh, Tatsuro. / Voriconazole-responsive disseminated nodular lesions on spinal MRI. In: Internal Medicine. 2015 ; Vol. 54, No. 2. pp. 215-218.
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Hirota, S, Ito, S, Fukui, T, Murate, K, Shima, S, Kizawa, M, Ueda, A, Asakura, K & Mutoh, T 2015, 'Voriconazole-responsive disseminated nodular lesions on spinal MRI', Internal Medicine, vol. 54, no. 2, pp. 215-218. https://doi.org/10.2169/internalmedicine.54.3148

Voriconazole-responsive disseminated nodular lesions on spinal MRI. / Hirota, Seiko; Ito, Shinji; Fukui, Takao; Murate, Kenichiro; Shima, Sayuri; Kizawa, Madoka; Ueda, Akihiro; Asakura, Kunihiko; Mutoh, Tatsuro.

In: Internal Medicine, Vol. 54, No. 2, 01.01.2015, p. 215-218.

Research output: Contribution to journalArticle

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