Voxel-based correlation between whole-brain CT perfusion with 320-row area detector CT and iodine 123 iodoamphetamine brain perfusion SPECT in patients with cerebrovascular disease

Kazuhiro Murayama, Hiroshi Toyama, Motoharu Hayakawa, Shuei Imizu, Tsutomu Soma, Akira Taniguchi, Kazuhiro Katada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: We compared cerebral blood flow (CBF) measured using computed tomographic (CT) perfusion (CTP) and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion single-photon emission computed tomography (SPECT).

Methods: We used a 320-row area detector CTand N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion SPECTunder similar conditions in patients with chronic cerebrovascular disease. Images were automatically aligned 3-dimensionally for voxel-by-voxel comparisons.

Results: Linear positive correlations were observed between CTPCBF including high-blood-flow areas and SPECT-CBF over the whole brain (r = 0.001-0.6, P < 0.01), superior cerebral level (r = 0.45-0.93, P < 0.01), basal ganglia level (r = 0.44-0.77, P < 0.01), and skull base (r = 0.02-0.66, P < 0.01). Correlations between CTP-CBF excluding high-blood-flow areas were significantly higher (P < 0.0001).

Conclusions: Computed tomographic perfusion overestimated CBF compared with SPECT and showed poor correlation at the skull base. Computed tomographic perfusion CTP excluding high-blood-flow areas improved the correlation over the whole brain in patients with chronic cerebrovascular disease.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalJournal of Computer Assisted Tomography
Volume38
Issue number5
DOIs
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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