Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model

K. Hikishima, K. Ando, Y. Komaki, K. Kawai, R. Yano, T. Inoue, T. Itoh, Masayuki Yamada, S. Momoshima, H. J. Okano, H. Okano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Movement dysfunction in Parkinson's disease (PD) is caused by the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Here, we established a method for voxel-based morphometry (VBM) and automatic tissue segmentation of the marmoset monkey brain using a 7-T animal scanner and applied the method to assess DA degeneration in a PD model, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated animals, with tyrosine-hydroxylase staining. The most significant decreases of local tissue volume were detected in the bilateral SN of MPTP-treated marmoset brains (-53.0% in right and -46.5% in left) and corresponded with the location of DA neurodegeneration found in histology (-65.4% in right). In addition to the SN, the decreases were also confirmed in the locus coeruleus, and lateral hypothalamus. VBM using 7-T MRI was effective in detecting volume loss in the SN of the PD-model marmoset. This study provides a potential basis for the application of VBM with ultra-high field MRI in the clinical diagnosis of PD. The developed method may also offer value in automatic whole-brain evaluation of structural changes for the marmoset monkey.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalNeuroscience
Volume300
DOIs
Publication statusPublished - 06-08-2015

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Callithrix
Substantia Nigra
Parkinson Disease
Brain
Haplorhini
Lateral Hypothalamic Area
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Locus Coeruleus
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
Histology
Staining and Labeling
4-phenyl-1,2,3,6-tetrahydropyridine

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hikishima, K. ; Ando, K. ; Komaki, Y. ; Kawai, K. ; Yano, R. ; Inoue, T. ; Itoh, T. ; Yamada, Masayuki ; Momoshima, S. ; Okano, H. J. ; Okano, H. / Voxel-based morphometry of the marmoset brain : In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model. In: Neuroscience. 2015 ; Vol. 300. pp. 585-592.
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Voxel-based morphometry of the marmoset brain : In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model. / Hikishima, K.; Ando, K.; Komaki, Y.; Kawai, K.; Yano, R.; Inoue, T.; Itoh, T.; Yamada, Masayuki; Momoshima, S.; Okano, H. J.; Okano, H.

In: Neuroscience, Vol. 300, 06.08.2015, p. 585-592.

Research output: Contribution to journalArticle

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T2 - In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model

AU - Hikishima, K.

AU - Ando, K.

AU - Komaki, Y.

AU - Kawai, K.

AU - Yano, R.

AU - Inoue, T.

AU - Itoh, T.

AU - Yamada, Masayuki

AU - Momoshima, S.

AU - Okano, H. J.

AU - Okano, H.

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