Waist circumference correlates with hepatic fat accumulation in male Japanese patients with non-alcoholic fatty liver disease, but not in females

Eriko Ishibashi, Yuichiro Eguchi, Takahisa Eguchi, Aki Matsunobu, Noriko Oza, Shunya Nakashita, Yoichiro Kitajima, Shigetaka Kuroki, Iwata Ozaki, Yasunori Kawaguchi, Yasushi Ide, Tsutomu Yasutake, Ryuichi Iwakiri, Toshihiko Mizuta, Naofumi Ono, Kazuma Fujimoto

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Background and Aim: Abdominal obesity, a component of metabolic syndrome, is a major risk factor for non-alcoholic fatty liver disease (NAFLD). In recent worldwide definitions of metabolic syndrome, waist measurement has been proposed as a simple and useful estimate of abdominal obesity, taking into account gender differences in waist circumference. The present cross-sectional study investigated the correlation of hepatic fat accumulation and waist circumference in Japanese NAFLD patients to determine if there are gender differences in this relationship. Methods: Consecutive patients (n = 2111) who had at least one of two criteria for liver disease (alanine aminotransferase [ALT] level >30 IU/mL and aspartate aminotransferase [AST]/ALT ratio <1) underwent abdominal ultrasonography. Patients positive for hepatitis B virus, hepatitis C virus or autoimmune antibodies and whose alcohol intake was >20 g/day were excluded. Patients with NAFLD underwent abdominal computed tomography. Hepatic fat accumulation was estimated by liver/spleen attenuation ratio (L/S ratio) and visceral adipose accumulation was measured as visceral fat area (VFA) at the umbilical level. Results: Of the 221 NAFLD patients, 103 were females. In males, the relationship between L/S ratio and waist circumference was negative (r = -0.356, P < 0.01), and there was no correlation in the female group. The relationship between L/S ratio and VFA was negative in both groups (males: r = -0.269, P < 0.01; females: r = -0.319, P < 0.01). Subcutaneous fat area/total fat area ratio at the umbilical level was larger in females than in males (P < 0.01). Conclusions: In NAFLD patients, waist measurement is more susceptible to gender differences than VFA.

Original languageEnglish
Pages (from-to)908-913
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume23
Issue number6
DOIs
Publication statusPublished - 06-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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