Walking capacity evaluated by the 6-minute walk test in spinal and bulbar muscular atrophy

Yu Takeuchi, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Motoshi Kawashima, Naoki Atsuta, Mizuki Ito, Hirohisa Watanabe, Fumiaki Tanaka, Gen Sobue

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. Because the progression of SBMA is slow, it is plausible to identify biomarkers that monitor disease course for therapeutic development. To verify whether the 6-min walk test (6MWT) is a biomarker of SBMA, we performed the 6MWT in 35 genetically confirmed patients and in 29 age-matched healthy controls. The walk distance covered within 6 min (6MWD) was significantly less in SBMA than it was in controls (323.3 ± 143.9 m and 637.6 ± 94.2 m, respectively; P < 0.001). In test-retest analysis, the intraclass correlation coefficient for the 6MWD was high in SBMA patients (r = 0.982). In a 1-year follow-up the 6MWD significantly decreased at a rate of 11.3% per year. Our observations suggest that the 6MWT is a biomarker that can be used to monitor progression of motor impairment in SBMA.

Original languageEnglish
Pages (from-to)964-971
Number of pages8
JournalMuscle and Nerve
Volume38
Issue number2
DOIs
Publication statusPublished - 01-08-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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  • Cite this

    Takeuchi, Y., Katsuno, M., Banno, H., Suzuki, K., Kawashima, M., Atsuta, N., Ito, M., Watanabe, H., Tanaka, F., & Sobue, G. (2008). Walking capacity evaluated by the 6-minute walk test in spinal and bulbar muscular atrophy. Muscle and Nerve, 38(2), 964-971. https://doi.org/10.1002/mus.21077