Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy

Tatsuya Murakami, Hirohide Sawada, Goshu Tamura, Masako Yudasaka, Sumio Iijima, Kunihiro Tsuchida

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Aim: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. Materials & methods: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. Results & discussion: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. Conclusions: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.

Original languageEnglish
Pages (from-to)453-463
Number of pages11
JournalNanomedicine
Volume3
Issue number4
DOIs
Publication statusPublished - 01-08-2008

Fingerprint

Nanohorns
chemotherapy
Drug Carriers
Chemotherapy
cancer
drug
Carbon
Drug Therapy
water
Water
carbon
tumor
interstitial
Tumors
Neoplasms
Doxorubicin
Polyethylene glycols
migration
Bearings (structural)
Extracellular Fluid

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

Cite this

Murakami, Tatsuya ; Sawada, Hirohide ; Tamura, Goshu ; Yudasaka, Masako ; Iijima, Sumio ; Tsuchida, Kunihiro. / Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy. In: Nanomedicine. 2008 ; Vol. 3, No. 4. pp. 453-463.
@article{6d43f2d40d5b4132934cd963bf1d68dc,
title = "Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy",
abstract = "Aim: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. Materials & methods: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. Results & discussion: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. Conclusions: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.",
author = "Tatsuya Murakami and Hirohide Sawada and Goshu Tamura and Masako Yudasaka and Sumio Iijima and Kunihiro Tsuchida",
year = "2008",
month = "8",
day = "1",
doi = "10.2217/17435889.3.4.453",
language = "English",
volume = "3",
pages = "453--463",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "4",

}

Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy. / Murakami, Tatsuya; Sawada, Hirohide; Tamura, Goshu; Yudasaka, Masako; Iijima, Sumio; Tsuchida, Kunihiro.

In: Nanomedicine, Vol. 3, No. 4, 01.08.2008, p. 453-463.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy

AU - Murakami, Tatsuya

AU - Sawada, Hirohide

AU - Tamura, Goshu

AU - Yudasaka, Masako

AU - Iijima, Sumio

AU - Tsuchida, Kunihiro

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Aim: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. Materials & methods: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. Results & discussion: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. Conclusions: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.

AB - Aim: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. Materials & methods: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. Results & discussion: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. Conclusions: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=56549127420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56549127420&partnerID=8YFLogxK

U2 - 10.2217/17435889.3.4.453

DO - 10.2217/17435889.3.4.453

M3 - Article

C2 - 18694307

AN - SCOPUS:56549127420

VL - 3

SP - 453

EP - 463

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 4

ER -