Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy

Tatsuya Murakami, Hirohide Sawada, Goshu Tamura, Masako Yudasaka, Sumio Iijima, Kunihiro Tsuchida

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Aim: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. Materials & methods: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. Results & discussion: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. Conclusions: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.

Original languageEnglish
Pages (from-to)453-463
Number of pages11
JournalNanomedicine
Volume3
Issue number4
DOIs
Publication statusPublished - 01-08-2008

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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