Watershed infarcts in a multiple microembolic model of monkey

Takakuni Maki; Hideaki Wakita; Mitsuhito Mase; Iori Itagaki; Naoyuki Saito; Fumiko Ono; Kayo Adachi; Hidefumi Ito; Ryosuke Takahashi; Masafumi Ihara; Hidekazu Tomimoto

doi:10.1016/j.neulet.2011.05.036

Watershed infarcts in a multiple microembolic model of monkey

Takakuni Maki, Hideaki Wakita, Mitsuhito Mase, Iori Itagaki, Naoyuki Saito, Fumiko Ono, Kayo Adachi, Hidefumi Ito, Ryosuke Takahashi, Masafumi Ihara, Hidekazu Tomimoto

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.

Original language	English
Pages (from-to)	80-83
Number of pages	4
Journal	Neuroscience Letters
Volume	499
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2011.05.036
Publication status	Published - 20-07-2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/j.neulet.2011.05.036

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title = "Watershed infarcts in a multiple microembolic model of monkey",

abstract = "It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.",

author = "Takakuni Maki and Hideaki Wakita and Mitsuhito Mase and Iori Itagaki and Naoyuki Saito and Fumiko Ono and Kayo Adachi and Hidefumi Ito and Ryosuke Takahashi and Masafumi Ihara and Hidekazu Tomimoto",

note = "Funding Information: This work was conducted through the Cooperative Research Program in Tsukuba Primate Research Center, National Institute of Biomedical Innovation supported by grants from the Ministry of Health, Labor and Welfare of Japan. The authors are very grateful to the staff at the Tsukuba Primate Research Center for their excellent animal care support and to Dr. Ahmad Khundakar for his thoughtful comments.",

year = "2011",

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doi = "10.1016/j.neulet.2011.05.036",

language = "English",

volume = "499",

pages = "80--83",

journal = "Neuroscience Letters",

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T1 - Watershed infarcts in a multiple microembolic model of monkey

AU - Maki, Takakuni

AU - Wakita, Hideaki

AU - Mase, Mitsuhito

AU - Itagaki, Iori

AU - Saito, Naoyuki

AU - Ono, Fumiko

AU - Adachi, Kayo

AU - Ito, Hidefumi

AU - Takahashi, Ryosuke

AU - Ihara, Masafumi

AU - Tomimoto, Hidekazu

N1 - Funding Information: This work was conducted through the Cooperative Research Program in Tsukuba Primate Research Center, National Institute of Biomedical Innovation supported by grants from the Ministry of Health, Labor and Welfare of Japan. The authors are very grateful to the staff at the Tsukuba Primate Research Center for their excellent animal care support and to Dr. Ahmad Khundakar for his thoughtful comments.

PY - 2011/7/20

Y1 - 2011/7/20

N2 - It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.

AB - It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.

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Watershed infarcts in a multiple microembolic model of monkey

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