Watershed infarcts in a multiple microembolic model of monkey

Takakuni Maki, Hideaki Wakita, Mitsuhito Mase, Iori Itagaki, Naoyuki Saito, Fumiko Ono, Kayo Adachi, Hidefumi Ito, Ryosuke Takahashi, Masafumi Ihara, Hidekazu Tomimoto

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Abstract

It has long been debated whether watershed infarcts are caused by hemodynamic or embolic mechanisms. In the present study, we investigated microembolic roles in the pathogenesis of watershed infarcts by examining MRI in a macaque monkey model of multiple microinfarcts. 50μm microbeads were injected into each internal carotid artery twice with a month interval. Monkeys (n=4) injected with 2250-2800 microbeads per unilateral side showed both cortical and internal watershed infarcts in the acute phase and atrophic changes with microbleeds in the chronic phase. These results suggest embolic pathogenesis can contribute to the genesis of both cortical and internal watershed infarcts in primates.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalNeuroscience Letters
Volume499
Issue number2
DOIs
Publication statusPublished - 20-07-2011

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Maki, T., Wakita, H., Mase, M., Itagaki, I., Saito, N., Ono, F., Adachi, K., Ito, H., Takahashi, R., Ihara, M., & Tomimoto, H. (2011). Watershed infarcts in a multiple microembolic model of monkey. Neuroscience Letters, 499(2), 80-83. https://doi.org/10.1016/j.neulet.2011.05.036