What autoantibody tests should become widely available to help scleroderma diagnosis and management?

Yoshinao Muro, Kazumitsu Sugiura, Masashi Akiyama

Research output: Contribution to journalEditorial

5 Citations (Scopus)

Abstract

Anti-Th/To autoantibodies have been recognized as serological markers of systemic sclerosis (SSc) for more than 20 years. However, validated immunoassay kits to test this specificity have not been commercially available. SSc autoantibodies are basically mutually exclusive and are associated with a certain subset of the disease and/or with organ involvement. Anti-Th/To are generally considered to be markers of the limited cutaneous type of SSc with the involvement of certain internal organs. The excellent correlation between anti-Rpp25 as detected by their novel chemiluminescent method and anti-Th/To as detected by immunoprecipitation suggest that the new assays may become widely available tests for clinicians in future and could help to clarify the clinical significance of anti-Th/To in SSc as well as other conditions over different races or countries.

Original languageEnglish
Article number116
JournalArthritis Research and Therapy
Volume15
Issue number4
DOIs
Publication statusPublished - 08-07-2013
Externally publishedYes

Fingerprint

Systemic Scleroderma
Autoantibodies
Immunoassay
Immunoprecipitation
Skin

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

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abstract = "Anti-Th/To autoantibodies have been recognized as serological markers of systemic sclerosis (SSc) for more than 20 years. However, validated immunoassay kits to test this specificity have not been commercially available. SSc autoantibodies are basically mutually exclusive and are associated with a certain subset of the disease and/or with organ involvement. Anti-Th/To are generally considered to be markers of the limited cutaneous type of SSc with the involvement of certain internal organs. The excellent correlation between anti-Rpp25 as detected by their novel chemiluminescent method and anti-Th/To as detected by immunoprecipitation suggest that the new assays may become widely available tests for clinicians in future and could help to clarify the clinical significance of anti-Th/To in SSc as well as other conditions over different races or countries.",
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What autoantibody tests should become widely available to help scleroderma diagnosis and management? / Muro, Yoshinao; Sugiura, Kazumitsu; Akiyama, Masashi.

In: Arthritis Research and Therapy, Vol. 15, No. 4, 116, 08.07.2013.

Research output: Contribution to journalEditorial

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AU - Sugiura, Kazumitsu

AU - Akiyama, Masashi

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