Which Kt/V is the most valid for assessment of both long mild and short intensive hemodialyses?

Toshihiko Miwa, Shigeru Nakai, Masamiki Miwa, Toru Shinzato, Kosei Segawa, Kenji Maeda

Research output: Contribution to journalArticlepeer-review

Abstract

It is unclear at present which mathematical modeling Kt/(V)urea is valid for assessment of both long mild hemodialysis (HD) and short intensive HD, the single-pool modeling Kt/V (Kt/Vsp) based on the pre- and postdialysis serum urea concentrations, double-pool modeling Kt/V (Kt/Vdp) based on the predialysis concentration and the estimated postdialysis equilibrated concentration, or Kt/V calculated on the basis of dialyzer urea clearance, HD session duration and urea distribution volume (Kt/Vdl). Thus, the respective Kt/V during a short intensive HD was compared with its counterpart Kt/V during a long mild HD, where the same amount of urea is removed during both HD treatments. It was found that the Kt/Vsp and Kt/Vdl during short intensive HD were significantly greater than the respective Kt/V during the long mild HD. On the other hand, there was no significant difference in the Kt/Vdp between the long mild and short intensive HDs. In conclusion, Kt/Vdp may be more valid for assessment of both long mild and short intensive HDs.

Original languageEnglish
Pages (from-to)827-831
Number of pages5
JournalNephron
Volume92
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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