TY - JOUR
T1 - White matter lesions after occlusion of the bilateral carotid arteries in the rat -temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin
AU - Tomimoto, Hidekazu
AU - Akiguchi, Ichiro
AU - Wakita, Hideaki
AU - Kimura, Jun
PY - 1997
Y1 - 1997
N2 - In the present investigation, we examined cerebral blood flow (CBF), numerical density of oligodendroRlia and extent of white matter lesions after bilateral libation of common carotid arteries in Wistar rats, Doppler flow meter re\ealed a reduction of CBF to 30-40, of that before operation after 1 and 3 days, however recovered to ,10 60 ‰, after 7 and 14 days, Semiquantitative evaluation with immuohistochemistry for transferrin showed a numerical decrease of oligodendroglia in the medial corpus callosum after 14 and !i() clays, Tissue rarefaction promptly occurred in the optic nerve and optic tract after ',', days, whereas it was- delayed to 7 clays after operation and increased in intensity gradually in the other white matter regions, These results indicate that bilateral occlusion of common carotid arteries in VVistar rats elicits a chronic cerebral hypoperfusion, which cumulatively leads to delayed appearance of white matter lesions,.
AB - In the present investigation, we examined cerebral blood flow (CBF), numerical density of oligodendroRlia and extent of white matter lesions after bilateral libation of common carotid arteries in Wistar rats, Doppler flow meter re\ealed a reduction of CBF to 30-40, of that before operation after 1 and 3 days, however recovered to ,10 60 ‰, after 7 and 14 days, Semiquantitative evaluation with immuohistochemistry for transferrin showed a numerical decrease of oligodendroglia in the medial corpus callosum after 14 and !i() clays, Tissue rarefaction promptly occurred in the optic nerve and optic tract after ',', days, whereas it was- delayed to 7 clays after operation and increased in intensity gradually in the other white matter regions, These results indicate that bilateral occlusion of common carotid arteries in VVistar rats elicits a chronic cerebral hypoperfusion, which cumulatively leads to delayed appearance of white matter lesions,.
KW - Cerebral blood flow
KW - Chronic cerebral hypoperfusion
KW - Myelin
KW - Oligodendroglia
KW - White matter
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M3 - Article
C2 - 9234252
AN - SCOPUS:0030840767
SN - 0006-8969
VL - 49
SP - 639
EP - 644
JO - Brain and Nerve
JF - Brain and Nerve
IS - 7
ER -