White matter lesions after occlusion of the bilateral carotid arteries in the rat -temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin

Hidekazu Tomimoto, Ichiro Akiguchi, Hideaki Wakita, Jun Kimura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In the present investigation, we examined cerebral blood flow (CBF), numerical density of oligodendroRlia and extent of white matter lesions after bilateral libation of common carotid arteries in Wistar rats, Doppler flow meter re\ealed a reduction of CBF to 30-40, of that before operation after 1 and 3 days, however recovered to ,10 60 ‰, after 7 and 14 days, Semiquantitative evaluation with immuohistochemistry for transferrin showed a numerical decrease of oligodendroglia in the medial corpus callosum after 14 and !i() clays, Tissue rarefaction promptly occurred in the optic nerve and optic tract after ',', days, whereas it was- delayed to 7 clays after operation and increased in intensity gradually in the other white matter regions, These results indicate that bilateral occlusion of common carotid arteries in VVistar rats elicits a chronic cerebral hypoperfusion, which cumulatively leads to delayed appearance of white matter lesions,.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalBrain and Nerve
Volume49
Issue number7
Publication statusPublished - 01-12-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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