Whole genome sequencing and evolutionary analysis of G8P [8] rotaviruses emerging in Japan

Tung Phan, Masaaki Kobayashi, Koo Nagasawa, Riona Hatazawa, Ngan Thi Kim Pham, Hideaki Miyashita, Satoshi Komoto, Takeshi Tajima, Tuneyoshi Baba, Shoko Okitsu, Pattara Khamrin, Niwat Maneekarn, Hirokazu Kimura, Takeshi Kobayashi, Satoshi Hayakawa, Hiroshi Ushijima

Research output: Contribution to journalArticlepeer-review

Abstract

Unusual DS-1-like intergenogroup reassortant rotaviruses with a bovine-like G8 genotype (DS-1-like G8P [8] rotaviruses) have emerged and rapidly spread in several countries. In this study, the nucleotide sequences of seven human rotavirus G8P [8] strains in 2017 and 2019 in Japan were determined using viral metagenomics. Its genomic constellation (VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes) was defined as G8-P [8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Our genetic analysis revealed that the Japanese G8P [8] rotavirus strains in 2017 and 2019 were classified into the same lineages G8-5 and P [8]-3, but they were phylogenetically located on separate branches and belonged to distinct clusters. Our study is the first attempt to investigate the evolution of emerging rotavirus G8P [8] in Japan.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalVirusDisease
Volume33
Issue number2
DOIs
Publication statusPublished - 06-2022

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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