Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

Tung Phan; Toshiyuki Hikita; Shoko Okitsu; Yuki Akari; Satoshi Komoto; Satoshi Hayakawa; Hiroshi Ushijima

doi:10.1007/s11262-023-02018-7

Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

Tung Phan
, Toshiyuki Hikita
, Shoko Okitsu
, Yuki Akari
, Satoshi Komoto
, Satoshi Hayakawa
, Hiroshi Ushijima

Research output: Contribution to journal › Article › peer-review

Abstract

After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.

Original language	English
Pages (from-to)	688-692
Number of pages	5
Journal	Virus Genes
Volume	59
Issue number	5
DOIs	https://doi.org/10.1007/s11262-023-02018-7
Publication status	Published - 10-2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Virology

Access to Document

10.1007/s11262-023-02018-7

Cite this

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title = "Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan",

abstract = "After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix{\textregistered} vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.",

author = "Tung Phan and Toshiyuki Hikita and Shoko Okitsu and Yuki Akari and Satoshi Komoto and Satoshi Hayakawa and Hiroshi Ushijima",

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doi = "10.1007/s11262-023-02018-7",

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T1 - Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

AU - Phan, Tung

AU - Hikita, Toshiyuki

AU - Okitsu, Shoko

AU - Akari, Yuki

AU - Komoto, Satoshi

AU - Hayakawa, Satoshi

AU - Ushijima, Hiroshi

PY - 2023/10

Y1 - 2023/10

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AB - After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.

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Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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