Working hours and risk of acute myocardial infarction and stroke among middle-aged japanese men

The Japan public health center-based prospective study cohort II

for the Japan Public Health Center-Based (JPHC) Prospective Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 personyears), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

Original languageEnglish
Pages (from-to)1072-1079
Number of pages8
JournalCirculation Journal
Volume83
Issue number5
DOIs
Publication statusPublished - 01-01-2019

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Japan
Public Health
Stroke
Myocardial Infarction
Prospective Studies
Confidence Intervals
Occupations
Proportional Hazards Models
Cohort Studies
Cardiovascular Diseases
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{38737556be724f2fa558a2925955668d,
title = "Working hours and risk of acute myocardial infarction and stroke among middle-aged japanese men: The Japan public health center-based prospective study cohort II",
abstract = "Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 personyears), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95{\%} confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95{\%} CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95{\%} CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95{\%} CI 1.42-4.77). Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.",
author = "{for the Japan Public Health Center-Based (JPHC) Prospective Study Group} and Rie Hayashi and Hiroyasu Iso and Kazumasa Yamagishi and Hiroshi Yatsuya and Isao Saito and Yoshihiro Kokubo and Eshak, {Ehab S.} and Norie Sawada and Shoichiro Tsugane",
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Working hours and risk of acute myocardial infarction and stroke among middle-aged japanese men : The Japan public health center-based prospective study cohort II. / for the Japan Public Health Center-Based (JPHC) Prospective Study Group.

In: Circulation Journal, Vol. 83, No. 5, 01.01.2019, p. 1072-1079.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Working hours and risk of acute myocardial infarction and stroke among middle-aged japanese men

T2 - The Japan public health center-based prospective study cohort II

AU - for the Japan Public Health Center-Based (JPHC) Prospective Study Group

AU - Hayashi, Rie

AU - Iso, Hiroyasu

AU - Yamagishi, Kazumasa

AU - Yatsuya, Hiroshi

AU - Saito, Isao

AU - Kokubo, Yoshihiro

AU - Eshak, Ehab S.

AU - Sawada, Norie

AU - Tsugane, Shoichiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 personyears), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

AB - Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 personyears), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

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JF - Circulation Journal

SN - 1346-9843

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