TY - JOUR
T1 - Xenon-enhanced CT using subtraction CT
T2 - Basic and preliminary clinical studies for comparison of its efficacy with that of dual-energy CT and ventilation SPECT/CT to assess regional ventilation and pulmonary functional loss in smokers
AU - Ohno, Yoshiharu
AU - Yoshikawa, Takeshi
AU - Takenaka, Daisuke
AU - Fujisawa, Yasuko
AU - Sugihara, Naoki
AU - Kishida, Yuji
AU - Seki, Shinichiro
AU - Koyama, Hisanobu
AU - Sugimura, Kazuro
N1 - Funding Information:
This study consisted of an in vitro xenon phantom study and an in vivo study of smoking subjects. In addition, the in vivo study was performed as a prospective study and approved by the institutional review board of Kobe University Graduate School of Medicine. Written informed consent was obtained from all patients. It was financially and technically supported by Toshiba Medical Systems Corporation. Two of the authors (Y.F. and N.S.), who are employees of Toshiba Medical Systems Corporation, developed the software, but had no control over any data or information submitted for publication or any control over any parts of data or information included in this study.
Funding Information:
This work was technically and financially supported by Toshiba Medical Systems Corporation.
Funding Information:
Drs. Ohno and Yoshikawa received the research grant from Toshiba Medical Systems Corporation. In addition, this work was financially and technically supported by Toshiba Medical Systems Corporation. Yasuko Fujisawa, BS and Naoki Sugihara, MEng are employees of Toshiba Medical Systems Corporation, developed the software, but had no control over any data or information submitted for publication or any control over any parts of data or information included in this study.
Funding Information:
Authors thank Wakiko Tani, RT, Toshiya Sekitani, RT, Noriyuki Negi, RT and Tohru Murakami, RT (Center for Radiology and Radiation Oncology, Kobe University Graduate School of Medicine) and Megumi Nishigaki, RT, Kenji Fujii, RT and Hiroyasu Inokawa, RT (Toshiba Medical Systems Corporation) for their excellent contribution to this work. Yasuko Fujisawa, BS and Naoki Sugihara, MEng are employees of Toshiba Medical Systems Corporation, developed the software, but had no control over any data or information submitted for publication or any control over any parts of data or information included in this study. This work was technically and financially supported by Toshiba Medical Systems Corporation .
Publisher Copyright:
© 2016 Elsevier Ireland Ltd
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Purpose To prospectively and directly compare the capability for assessments of regional ventilation and pulmonary functional loss in smokers of xenon-ventilation CT obtained with the dual-energy CT (DE-CT) and subtraction CT (Sub-CT) Materials and methods Twenty-three consecutive smokers (15 men and 8 women, mean age: 69.7 ± 8.7 years) underwent prospective unenhanced and xenon-enhanced CTs, the latter by Sub-CT and DE-CT methods, ventilation SPECT and pulmonary function tests. Sub-CT was generated from unenhanced and xenon-enhanced CT, and all co-registered SPECT/CT data were produced from SPECT and unenhanced CT data. For each method, regional ventilation was assessed by using a 11-point scoring system on a per-lobe basis. To determine the functional lung volume by each method, it was also calculated for individual sublets with a previously reported method. To determine inter-observer agreement for each method, ventilation defect assessment was evaluated by using the χ2 test with weighted kappa statistics. For evaluation of the efficacy of each method for pulmonary functional loss assessment, functional lung volume was correlated with%FEV1. Results Each inter-observer agreement was rated as substantial (Sub-CT: κ = 0.69, p < 0.0001; DE-CT: κ = 0.64, p < 0.0001; SPECT/CT: κ = 0.64, p < 0.0001). Functional lung volume for each method showed significant to good correlation with%FEV1 (Sub-CT: r = 0.72, p = 0.0001; DE-CT: r = 0.74, p < 0.0001; SPECT/CT: r = 0.66, p = 0.0006). Conclusion Xenon-enhanced CT obtained by Sub-CT can be considered at least as efficacious as that obtained by DE-CT and SPECT/CT for assessment of ventilation abnormality and pulmonary functional loss in smokers.
AB - Purpose To prospectively and directly compare the capability for assessments of regional ventilation and pulmonary functional loss in smokers of xenon-ventilation CT obtained with the dual-energy CT (DE-CT) and subtraction CT (Sub-CT) Materials and methods Twenty-three consecutive smokers (15 men and 8 women, mean age: 69.7 ± 8.7 years) underwent prospective unenhanced and xenon-enhanced CTs, the latter by Sub-CT and DE-CT methods, ventilation SPECT and pulmonary function tests. Sub-CT was generated from unenhanced and xenon-enhanced CT, and all co-registered SPECT/CT data were produced from SPECT and unenhanced CT data. For each method, regional ventilation was assessed by using a 11-point scoring system on a per-lobe basis. To determine the functional lung volume by each method, it was also calculated for individual sublets with a previously reported method. To determine inter-observer agreement for each method, ventilation defect assessment was evaluated by using the χ2 test with weighted kappa statistics. For evaluation of the efficacy of each method for pulmonary functional loss assessment, functional lung volume was correlated with%FEV1. Results Each inter-observer agreement was rated as substantial (Sub-CT: κ = 0.69, p < 0.0001; DE-CT: κ = 0.64, p < 0.0001; SPECT/CT: κ = 0.64, p < 0.0001). Functional lung volume for each method showed significant to good correlation with%FEV1 (Sub-CT: r = 0.72, p = 0.0001; DE-CT: r = 0.74, p < 0.0001; SPECT/CT: r = 0.66, p = 0.0006). Conclusion Xenon-enhanced CT obtained by Sub-CT can be considered at least as efficacious as that obtained by DE-CT and SPECT/CT for assessment of ventilation abnormality and pulmonary functional loss in smokers.
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U2 - 10.1016/j.ejrad.2016.10.035
DO - 10.1016/j.ejrad.2016.10.035
M3 - Article
C2 - 28027764
AN - SCOPUS:84994032252
VL - 86
SP - 41
EP - 51
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
ER -