Zinc-dependent binding between peptides derived from rainbow trout CD8α and LCK

Nobuhiro Hayashi; Masami Takeuchi; Teruyuki Nakanishi; Keiichiro Hashimoto; Johannes Martinus Dijkstra

doi:10.1016/j.fsi.2009.09.020

Zinc-dependent binding between peptides derived from rainbow trout CD8α and LCK

Nobuhiro Hayashi, Masami Takeuchi, Teruyuki Nakanishi, Keiichiro Hashimoto, Johannes Martinus Dijkstra

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The cytoplasmic tail of mammalian CD8α binds the kinase LCK in a zinc-dependent manner. In analogy with a previous study for humans (Kim et al., 2003) peptides were synthesized from rainbow trout CD8α and LCK. Surface plasmon resonance (SPR) analysis indicated that also in fish these molecules bind to each other in a zinc-dependent manner.

Original language	English
Pages (from-to)	72-76
Number of pages	5
Journal	Fish and Shellfish Immunology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.fsi.2009.09.020
Publication status	Published - 01-2010

All Science Journal Classification (ASJC) codes

Immunology
Environmental Chemistry
Aquatic Science
Immunology and Microbiology (miscellaneous)

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10.1016/j.fsi.2009.09.020

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abstract = "The cytoplasmic tail of mammalian CD8α binds the kinase LCK in a zinc-dependent manner. In analogy with a previous study for humans (Kim et al., 2003) peptides were synthesized from rainbow trout CD8α and LCK. Surface plasmon resonance (SPR) analysis indicated that also in fish these molecules bind to each other in a zinc-dependent manner.",

keywords = "CD8α, CD8β, Cytoplasmic tail, LCK, Rainbow trout, Surface plasmon resonance binding assay, Zinc clasp",

author = "Nobuhiro Hayashi and Masami Takeuchi and Teruyuki Nakanishi and Keiichiro Hashimoto and Dijkstra, {Johannes Martinus}",

year = "2010",

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AU - Takeuchi, Masami

AU - Nakanishi, Teruyuki

AU - Hashimoto, Keiichiro

AU - Dijkstra, Johannes Martinus

PY - 2010/1

Y1 - 2010/1

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AB - The cytoplasmic tail of mammalian CD8α binds the kinase LCK in a zinc-dependent manner. In analogy with a previous study for humans (Kim et al., 2003) peptides were synthesized from rainbow trout CD8α and LCK. Surface plasmon resonance (SPR) analysis indicated that also in fish these molecules bind to each other in a zinc-dependent manner.

KW - CD8α

KW - CD8β

KW - Cytoplasmic tail

KW - LCK

KW - Rainbow trout

KW - Surface plasmon resonance binding assay

KW - Zinc clasp

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Zinc-dependent binding between peptides derived from rainbow trout CD8α and LCK

Abstract

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