精神神経科学

研究成果 1992 2020

2020

Long-Term Safety and Efficacy of Blonanserin Transdermal Patches in Japanese Patients with Schizophrenia: A 52-Week Open-Label, Multicenter Study

Iwata, N., Ishigooka, J., Naoi, I., Matsumoto, M., Kanamori, Y., Nakamura, H. & Higuchi, T., 01-01-2020, : : CNS Drugs. 34, 1, p. 103-116 14 p.

研究成果: Article

公開
Transdermal Patch
Multicenter Studies
Schizophrenia
Safety
Tablets

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi, S., Ninomiya, K., Kushima, I., Saito, T., Shimasaki, A., Sakusabe, T., Momozawa, Y., Kubo, M., Kamatani, Y., Ozaki, N., Ikeda, M. & Iwata, N., 01-01-2020, : : Psychiatry and clinical neurosciences. 74, 1, p. 35-39 5 p.

研究成果: Article

公開
Schizophrenia
Comparative Genomic Hybridization
Single Nucleotide Polymorphism
2019

A polygenic resilience score moderates the genetic risk for schizophrenia

The Schizophrenia Working Group of the Psychiatric Genomics Consortium & Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), 01-01-2019, (Accepted/In press) : : Molecular Psychiatry.

研究成果: Article

公開
Schizophrenia
Disease Resistance
Penetrance
Genomics
Psychiatry

A single-nucleotide polymorphism influences brain morphology in drug-näve patients with major depressive disorder

Katsuki, A., Kakeda, S., Watanabe, K., Igata, R., Otsuka, Y., Kishi, T., Nguyen, L. H., Ueda, I., Iwata, N., Korogi, Y. & Yoshimura, R., 01-01-2019, : : Neuropsychiatric Disease and Treatment. 15, p. 2425-2432 8 p.

研究成果: Article

公開
Major Depressive Disorder
Single Nucleotide Polymorphism
Brain
Pharmaceutical Preparations
Genotype

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region with Cortical and Subcortical Morphology and Cognition

Van Der Meer, D., Sønderby, I. E., Kaufmann, T., Walters, G. B., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N. J., Bernard, M., Blackburn, N. B., Blangero, J., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Bülow, R., Cahn, W., Calhoun, V. D., Caspers, S., Cavalleri, G. L. および112人, Ching, C. R. K., Cichon, S., Ciufolini, S., Corvin, A., Crespo-Facorro, B., Curran, J. E., Dalvie, S., Dazzan, P., De Geus, E. J. C., De Zubicaray, G. I., De Zwarte, S. M. C., Delanty, N., Den Braber, A., Desrivieres, S., Di Forti, M., Doherty, J. L., Donohoe, G., Ehrlich, S., Eising, E., Espeseth, T., Fisher, S. E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Glahn, D. C., Grabe, H. J., Groenewold, N. A., Gústafsson, Ó., Haavik, J., Haberg, A. K., Hashimoto, R., Hehir-Kwa, J. Y., Hibar, D. P., Hillegers, M. H. J., Hoffmann, P., Holleran, L., Hottenga, J. J., Hulshoff Pol, H. E., Ikeda, M., Jacquemont, S., Jahanshad, N., Jockwitz, C., Johansson, S., Jönsson, E. G., Kikuchi, M., Knowles, E. E. M., Kwok, J. B., Le Hellard, S., Linden, D. E. J., Liu, J., Lundervold, A., Lundervold, A. J., Martin, N. G., Mather, K. A., Mathias, S. R., McMahon, K. L., McRae, A. F., Medland, S. E., Moberget, T., Moreau, C., Morris, D. W., Mühleisen, T. W., Murray, R. M., Nordvik, J. E., Nyberg, L., Olde Loohuis, L. M., Ophoff, R. A., Owen, M. J., Paus, T., Pausova, Z., Peralta, J. M., Pike, B., Prieto, C., Quinlan, E. B., Reinbold, C. S., Reis Marques, T., Rucker, J. J. H., Sachdev, P. S., Sando, S. B., Schofield, P. R., Schork, A. J., Schumann, G., Shin, J., Shumskaya, E., Silva, A. I., Sisodiya, S. M., Steen, V. M., Stein, D. J., Strike, L. T., Tamnes, C. K., Teumer, A., Thalamuthu, A., Tordesillas-Gutiérrez, D., Uhlmann, A., Úlfarsson, M., Van 'T Ent, D., Van Den Bree, M. B. M., Vassos, E., Wen, W., Wittfeld, K., Wright, M. J., Zayats, T., Dale, A. M., Djurovic, S., Agartz, I., Westlye, L. T., Stefánsson, H., Stefánsson, K., Thompson, P. M. & Andreassen, O. A., 01-01-2019, (Accepted/In press) : : JAMA Psychiatry.

研究成果: Article

Cognition
Aptitude
Brain
Iceland
Parietal Lobe
公開
Major Depressive Disorder
Treatment Failure
Antidepressive Agents
Meta-Analysis
Odds Ratio
1 引用 (Scopus)
Bipolar Disorder
Randomized Controlled Trials
Placebos
Incidence
Network Meta-Analysis

COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder

Otsuka, Y., Kakeda, S., Sugimoto, K., Katsuki, A., Nguyen, L. H., Igata, R., Watanabe, K., Ueda, I., Kishi, T., Iwata, N., Korogi, Y. & Yoshimura, R., 01-01-2019, : : Neuropsychiatric Disease and Treatment. 15, p. 1537-1545 9 p.

研究成果: Article

公開
Catechol O-Methyltransferase
Major Depressive Disorder
Hippocampus
Genotype
Pharmaceutical Preparations
公開
Basal Ganglia
Psychiatry
Publications
Datasets
Bipolar Disorder
Cross-Sectional Studies
Depression
Light
Odds Ratio
3 引用 (Scopus)

Effect of discontinuation v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episode psychosis: A meta-analysis

Kishi, T., Ikuta, T., Matsui, Y., Inada, K., Matsuda, Y., Mishima, K. & Iwata, N., 01-04-2019, : : Psychological Medicine. 49, 5, p. 772-779 8 p.

研究成果: Article

Psychotic Disorders
Antipsychotic Agents
Meta-Analysis
Maintenance
Recurrence
6 引用 (Scopus)

Efficacy, Tolerability, and Safety of Blonanserin in Schizophrenia: An Updated and Extended Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kishi, T., Matsui, Y., Matsuda, Y., Katsuki, A., Hori, H., Yanagimoto, H., Sanada, K., Morita, K., Yoshimura, R., Shoji, Y., Hagi, K. & Iwata, N., 07-03-2019, : : Pharmacopsychiatry. 52, 2, p. 52-62 11 p.

研究成果: Article

Meta-Analysis
Schizophrenia
Randomized Controlled Trials
Safety
Risperidone
1 引用 (Scopus)

Efficacy and safety of blonanserin transdermal patch in patients with schizophrenia: A 6-week randomized, double-blind, placebo-controlled, multicenter study

Iwata, N., Ishigooka, J., Kim, W. H., Yoon, B. H., Lin, S. K., Sulaiman, A. H., Cosca, R., Wang, L., Suchkov, Y., Agarkov, A., Watabe, K., Matsui, T., Sato, T., Inoue, Y., Higuchi, T., Correll, C. U. & Kane, J. M., 01-01-2019, (Accepted/In press) : : Schizophrenia Research.

研究成果: Article

公開
Transdermal Patch
Multicenter Studies
Schizophrenia
Placebos
Safety

Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design

Oya, K., Sakuma, K., Esumi, S., Hashimoto, Y., Hatano, M., Matsuda, Y., Matsui, Y., Miyake, N., Nomura, I., Okuya, M., Iwata, N., Kato, M., Hashimoto, R., Mishima, K., Watanabe, N. & Kishi, T., 01-09-2019, : : Neuropsychopharmacology reports. 39, 3, p. 241-246 6 p.

研究成果: Article

公開
Bipolar Disorder
Lithium
Meta-Analysis
Randomized Controlled Trials
Placebos
10 引用 (Scopus)

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

CommonMind Consortium, The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium & iPSYCH-GEMS Schizophrenia Working Group, 01-04-2019, : : Nature Genetics. 51, 4, p. 659-674 16 p.

研究成果: Article

Genome-Wide Association Study
Prefrontal Cortex
Schizophrenia
Tay-Sachs Disease
Gene Expression
1 引用 (Scopus)

Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms

Kakeda, S., Watanabe, K., Katsuki, A., Sugimoto, K., Ueda, I., Igata, N., Kishi, T., Iwata, N., Abe, O., Yoshimura, R. & Korogi, Y., 01-01-2019, : : Neuropsychiatric Disease and Treatment. 15, p. 375-383 9 p.

研究成果: Article

公開
Diffusion Tensor Imaging
Genetic Loci
Major Depressive Disorder
Depression
Single Nucleotide Polymorphism
4 引用 (Scopus)

Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect

Ikeda, M., Takahashi, A., Kamatani, Y., Momozawa, Y., Saito, T., Kondo, K., Shimasaki, A., Kawase, K., Sakusabe, T., Iwayama, Y., Toyota, T., Wakuda, T., Kikuchi, M., Kanahara, N., Yamamori, H., Yasuda, Y., Watanabe, Y., Hoya, S., Aleksic, B., Kushima, I. および12人, Arai, H., Takaki, M., Hattori, K., Kunugi, H., Okahisa, Y., Ohnuma, T., Ozaki, N., Someya, T., Hashimoto, R., Yoshikawa, T., Kubo, M. & Iwata, N., 01-01-2019, : : Schizophrenia Bulletin. 45, 4, p. 824-834 11 p.

研究成果: Article

Genome-Wide Association Study
Population Genetics
Schizophrenia
Genes
Bipolar Disorder
Genome-Wide Association Study
Major Depressive Disorder
Psychology
Population
Far East
2 引用 (Scopus)

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 01-05-2019, : : Nature Human Behaviour. 3, 5, p. 471-477 7 p.

研究成果: Letter

Genetic Loci
Genome-Wide Association Study
Smoking
Linkage Disequilibrium
Tobacco Products
10 引用 (Scopus)

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Suzuki, K., Akiyama, M., Ishigaki, K., Kanai, M., Hosoe, J., Shojima, N., Hozawa, A., Kadota, A., Kuriki, K., Naito, M., Tanno, K., Ishigaki, Y., Hirata, M., Matsuda, K., Iwata, N., Ikeda, M., Sawada, N., Yamaji, T., Iwasaki, M., Ikegawa, S. および12人, Maeda, S., Murakami, Y., Wakai, K., Tsugane, S., Sasaki, M., Yamamoto, M., Okada, Y., Kubo, M., Kamatani, Y., Horikoshi, M., Yamauchi, T. & Kadowaki, T., 01-03-2019, : : Nature Genetics. 51, 3, p. 379-386 8 p.

研究成果: Letter

Genome-Wide Association Study
Gene Frequency
Type 2 Diabetes Mellitus
Population
Acinar Cells

Light exposure at night and sleep quality in bipolar disorder: The APPLE cohort study

Esaki, Y., Kitajima, T., Obayashi, K., Saeki, K., Fujita, K. & Iwata, N., 01-10-2019, : : Journal of Affective Disorders. 257, p. 314-320 7 p.

研究成果: Article

Bipolar Disorder
Sleep
Cohort Studies
Light
Actigraphy
1 引用 (Scopus)
公開
Melatonin Receptors
Bipolar Disorder
Meta-Analysis
Randomized Controlled Trials
Melatonin

New subtyping of insomnia disorder

Kitajima, T., 02-2019, : : The Lancet Psychiatry. 6, 2, p. 86-88 3 p.

研究成果: Comment/debate

Sleep Initiation and Maintenance Disorders
公開
Major Depressive Disorder
Catecholamines
Interleukin-6
Homovanillic Acid
Diagnostic and Statistical Manual of Mental Disorders
1 引用 (Scopus)

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04-2019, : : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.

研究成果: Article

Exome
Haplotypes
Genome-Wide Association Study
Schizophrenia
Population

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01-06-2019, : : Nature Genetics. 51, 6, 1 p.

研究成果: Comment/debate

公開
Genomics
Psychiatry
Schizophrenia
Gene Expression
Brain

Quetiapine extended-release vs olanzapine for Japanese patients with bipolar depression: A Bayesian analysis

Kishi, T., Ikuta, T., Matsuda, Y. & Iwata, N., 01-09-2019, : : Neuropsychopharmacology reports. 39, 3, p. 256-259 4 p.

研究成果: Article

公開
olanzapine
Bayes Theorem
Bipolar Disorder
Odds Ratio
Depression

Rare compound heterozygous missense SPATA7 variations and risk of schizophrenia; whole-exome sequencing in a consanguineous family with affected siblings, follow-up sequencing and a casecontrol study

Igeta, H., Watanabe, Y., Morikawa, R., Ikeda, M., Otsuka, I., Hoya, S., Koizumi, M., Egawa, J., Hishimoto, A., Iwata, N. & Someya, T., 01-01-2019, : : Neuropsychiatric Disease and Treatment. 15, p. 2353-2363 11 p.

研究成果: Article

公開
Exome
Siblings
Schizophrenia
Case-Control Studies
Parents
4 引用 (Scopus)

Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

Nguyen, L. H., Kakeda, S., Katsuki, A., Sugimoto, K., Otsuka, Y., Ueda, I., Igata, R., Watanabe, K., Kishi, T., Iwata, N., Korogi, Y. & Yoshimura, R., 01-10-2019, : : European Archives of Psychiatry and Clinical Neuroscience. 269, 7, p. 785-794 10 p.

研究成果: Article

Major Depressive Disorder
Vascular Endothelial Growth Factor A
Single Nucleotide Polymorphism
Brain
Genotype

Response to the Letter from Dr. Jacob Peedicayil

Sakuma, K., Kishi, T. & Iwata, N., 01-04-2019, : : Psychopharmacology. 236, 4, p. 1403-1404 2 p.

研究成果: Letter

Suvorexant for insomnia in patients with psychiatric disorder: A 1-week, open-label study

Kishi, T., Sakuma, K., Okuya, M., Ninomiya, K., Oya, K., Kubo, M., Matsui, Y., Nomura, I., Okuyama, Y., Matsunaga, S. & Iwata, N., 01-09-2019, : : Neuropsychopharmacology reports. 39, 3, p. 252-255 4 p.

研究成果: Article

公開
Sleep Initiation and Maintenance Disorders
Psychiatry
Sleep
Safety
Major Depressive Disorder

The effects of different periods of co-administration of oral and long-acting injectable aripiprazole: A propensity score analysis

Hatano, M., Kamei, H., Takeuchi, I., Tozawa, K., Makino, S., Hanya, M., Yamada, S. & Iwata, N., 01-2019, : : Human Psychopharmacology. 34, 1, e2681.

研究成果: Article

Propensity Score
Oral Administration
Injections
Aripiprazole
Treatment Failure

The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies

Liu, C., Kanazawa, T., Tian, Y., Mohamed Saini, S., Mancuso, S., Mostaid, M. S., Takahashi, A., Zhang, D., Zhang, F., Yu, H., Doo Shin, H., Sub Cheong, H., Ikeda, M., Kubo, M., Iwata, N., Woo, S. I., Yue, W., Kamatani, Y., Shi, Y., Li, Z. および3人, Everall, I., Pantelis, C. & Bousman, C., 01-12-2019, : : Translational psychiatry. 9, 1, 205.

研究成果: Article

公開
Knowledge Bases
Schizophrenia
Meta-Analysis
Genes
Single Nucleotide Polymorphism
2018
1 引用 (Scopus)
Circadian Rhythm Sleep Disorders
Education
Actigraphy
Photoperiod
Sleep

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 25-06-2018, : : BMC Genomics. 19, 1, 494.

研究成果: Article

Genome-Wide Association Study
5 引用 (Scopus)

Age at first birth in women is genetically associated with increased risk of schizophrenia

Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F. および281人, Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Haan, L. D., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Juliá, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'callaghan, E., O'dushlaine, C., O'neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Os, J. V., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'donovan, M. C., 01-12-2018, : : Scientific reports. 8, 1, 10168.

研究成果: Article

Birth Order
Schizophrenia
Parents
Mental Health
Genetic Heterogeneity
40 引用 (Scopus)

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

Advanced Collaborative Study of Mood Disorder (COSMO) team, 01-03-2018, : : Molecular Psychiatry. 23, 3, p. 639-647 9 p.

研究成果: Article

Genome-Wide Association Study
Bipolar Disorder
Population
Psychiatry
Regulator Genes
3 引用 (Scopus)

Anti-dementia drugs for psychopathology and cognitive impairment in schizophrenia: A systematic review and meta-analysis

Kishi, T., Ikuta, T., Oya, K., Matsunaga, S., Matsuda, Y. & Iwata, N., 01-01-2018, : : International Journal of Neuropsychopharmacology. 21, 8, p. 748-757 10 p.

研究成果: Review article

Psychopathology
Antipsychotic Agents
Dementia
Meta-Analysis
Schizophrenia
1 引用 (Scopus)

A retrospective study of the efficacy of ramelteon for insomnia: relevance of dose and timing of administration

Watanabe, A., Hirose, M., Kitajima, T., Tomita, S., Esaki, Y. & Iwata, N., 01-01-2018, : : Sleep and Biological Rhythms. 16, 1, p. 69-75 7 p.

研究成果: Article

Sleep Initiation and Maintenance Disorders
Retrospective Studies
Sleep
Psychiatry
ramelteon

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka, K., Kimura, H., Kushima, I., Inada, T., Okahisa, Y., Ikeda, M., Iwata, N., Mori, D., Aleksic, B. & Ozaki, N., 01-10-2018, : : Psychiatric Genetics. 28, 5, p. 90-93 4 p.

研究成果: Article

Lactoylglutathione Lyase
Schizophrenia
Penetrance
Gene Frequency
Exons
3 引用 (Scopus)
Sleep Initiation and Maintenance Disorders
GABA-A Receptors
Retrospective Studies
Aminobutyrates
Prescription Drugs
26 引用 (Scopus)

Brain-derived neurotrophic factor and major depressive disorder: Evidence from meta-analyses

Kishi, T., Yoshimura, R., Ikuta, T. & Iwata, N., 17-01-2018, : : Frontiers in Psychiatry. 8, JAN, 308.

研究成果: Short survey

Brain-Derived Neurotrophic Factor
Major Depressive Disorder
Meta-Analysis
Antidepressive Agents
Genes
3 引用 (Scopus)
Memantine
Obsessive-Compulsive Disorder
Serotonin Uptake Inhibitors
Meta-Analysis
Randomized Controlled Trials
25 引用 (Scopus)

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

Kushima, I., Aleksic, B., Nakatochi, M., Shimamura, T., Okada, T., Uno, Y., Morikawa, M., Ishizuka, K., Shiino, T., Kimura, H., Arioka, Y., Yoshimi, A., Takasaki, Y., Yu, Y., Nakamura, Y., Yamamoto, M., Iidaka, T., Iritani, S., Inada, T., Ogawa, N. および60人, Shishido, E., Torii, Y., Kawano, N., Omura, Y., Yoshikawa, T., Uchiyama, T., Yamamoto, T., Ikeda, M., Hashimoto, R., Yamamori, H., Yasuda, Y., Someya, T., Watanabe, Y., Egawa, J., Nunokawa, A., Itokawa, M., Arai, M., Miyashita, M., Kobori, A., Suzuki, M., Takahashi, T., Usami, M., Kodaira, M., Watanabe, K., Sasaki, T., Kuwabara, H., Tochigi, M., Nishimura, F., Yamasue, H., Eriguchi, Y., Benner, S., Kojima, M., Yassin, W., Munesue, T., Yokoyama, S., Kimura, R., Funabiki, Y., Kosaka, H., Ishitobi, M., Ohmori, T., Numata, S., Yoshikawa, T., Toyota, T., Yamakawa, K., Suzuki, T., Inoue, Y., Nakaoka, K., Goto, Y. I., Inagaki, M., Hashimoto, N., Kusumi, I., Son, S., Murai, T., Ikegame, T., Okada, N., Kasai, K., Kunimoto, S., Mori, D., Iwata, N. & Ozaki, N., 11-09-2018, : : Cell Reports. 24, 11, p. 2838-2856 19 p.

研究成果: Article

Schizophrenia
Genes
Oxidative stress
Bioinformatics
Intellectual Disability

Comparison of the efficacy and safety of 4 and 2 mg/day brexpiprazole for acute schizophrenia: A meta-analysis of double-blind, randomized placebo-controlled trials

Kishi, T., Oya, K., Matsui, Y., Nomura, I., Sakuma, K., Okuya, M., Matsuda, Y., Fujita, K., Funahashi, T., Yoshimura, R. & Iwata, N., 01-01-2018, : : Neuropsychiatric Disease and Treatment. 14, p. 2519-2530 12 p.

研究成果: Article

Meta-Analysis
Schizophrenia
Randomized Controlled Trials
Placebos
Safety
2 引用 (Scopus)

Decreased serum pyridoxal levels in schizophrenia: Meta-analysis and Mendelian randomization analysis

Tomioka, Y., Numata, S., Kinoshita, M., Umehara, H., Watanabe, S. Y., Nakataki, M., Iwayama, Y., Toyota, T., Ikeda, M., Yamamori, H., Shimodera, S., Tajima, A., Hashimoto, R., Iwata, N., Yoshikawa, T. & Ohmori, T., 05-2018, : : Journal of Psychiatry and Neuroscience. 43, 3, p. 194-200 7 p.

研究成果: Article

Mendelian Randomization Analysis
Pyridoxal
Meta-Analysis
Schizophrenia
Serum
2 引用 (Scopus)

DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder

Sugawara, H., Murata, Y., Ikegame, T., Sawamura, R., Shimanaga, S., Takeoka, Y., Saito, T., Ikeda, M., Yoshikawa, A., Nishimura, F., Kawamura, Y., Kakiuchi, C., Sasaki, T., Iwata, N., Hashimoto, M., Kasai, K., Kato, T., Bundo, M. & Iwamoto, K., 04-2018, : : Psychiatry and clinical neurosciences. 72, 4, p. 245-254 10 p.

研究成果: Article

Genetic Association Studies
DNA Methylation
Bipolar Disorder
Epigenomics
Schizophrenia
2 引用 (Scopus)
Intravenous Immunoglobulins
Intravenous Administration
Meta-Analysis
Alzheimer Disease
Safety
17 引用 (Scopus)

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Wellcome Trust Case Control Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Psychosis Endophenotypes International Consortium, 07-06-2018, : : American Journal of Human Genetics. 102, 6, p. 1185-1194 10 p.

研究成果: Article

Linkage Disequilibrium
Schizophrenia
Likelihood Functions
Genetic Heterogeneity
Nucleic Acid Regulatory Sequences
7 引用 (Scopus)

Folic acid/methylfolate for the treatment of psychopathology in schizophrenia: a systematic review and meta-analysis

Sakuma, K., Matsunaga, S., Nomura, I., Okuya, M., Kishi, T. & Iwata, N., 01-08-2018, : : Psychopharmacology. 235, 8, p. 2303-2314 12 p.

研究成果: Article

Psychopathology
Folic Acid
Meta-Analysis
Schizophrenia
Randomized Controlled Trials