精神神経科学

研究成果 1992 2020

フィルター
Letter
2019
2 引用 (Scopus)

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Matoba, N., Akiyama, M., Ishigaki, K., Kanai, M., Takahashi, A., Momozawa, Y., Ikegawa, S., Ikeda, M., Iwata, N., Hirata, M., Matsuda, K., Kubo, M., Okada, Y. & Kamatani, Y., 01-05-2019, : : Nature Human Behaviour. 3, 5, p. 471-477 7 p.

研究成果: Letter

Genetic Loci
Genome-Wide Association Study
Smoking
Linkage Disequilibrium
Tobacco Products
10 引用 (Scopus)

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Suzuki, K., Akiyama, M., Ishigaki, K., Kanai, M., Hosoe, J., Shojima, N., Hozawa, A., Kadota, A., Kuriki, K., Naito, M., Tanno, K., Ishigaki, Y., Hirata, M., Matsuda, K., Iwata, N., Ikeda, M., Sawada, N., Yamaji, T., Iwasaki, M., Ikegawa, S. および12人, Maeda, S., Murakami, Y., Wakai, K., Tsugane, S., Sasaki, M., Yamamoto, M., Okada, Y., Kubo, M., Kamatani, Y., Horikoshi, M., Yamauchi, T. & Kadowaki, T., 01-03-2019, : : Nature Genetics. 51, 3, p. 379-386 8 p.

研究成果: Letter

Genome-Wide Association Study
Gene Frequency
Type 2 Diabetes Mellitus
Population
Acinar Cells

Response to the Letter from Dr. Jacob Peedicayil

Sakuma, K., Kishi, T. & Iwata, N., 01-04-2019, : : Psychopharmacology. 236, 4, p. 1403-1404 2 p.

研究成果: Letter

2018

Response to the letter from Dr. Kim and colleagues

Kishi, T., Nomura, I., Ikuta, T. & Iwata, N., 05-2018, : : Psychiatry Research. 263, p. 291-292 2 p.

研究成果: Letter

2017
5 引用 (Scopus)

Optimizing outcomes in clozapine rechallenge following neutropenia using human leukocyte antigen typing: A case report

Yamaki, N., Hishimoto, A., Otsuka, I., Sasada, T., Boku, S., Saito, T., Yasuda, Y., Yamamori, H., Ikeda, M., Ikeda, M., Sora, I., Iwata, N. & Hashimoto, R., 01-04-2017, : : Psychiatry and clinical neurosciences. 71, 4, p. 289-290 2 p.

研究成果: Letter

Clozapine
HLA Antigens
Neutropenia
2 引用 (Scopus)

Reliability and validity of the California Verbal Learning Test-II – Japanese version

Sumiyoshi, T., Toyomaki, A., Kawano, N., Kitajima, T., Kusumi, I., Ozaki, N., Iwata, N. & Nakagome, K., 06-2017, : : Psychiatry and clinical neurosciences. 71, 6, p. 417-418 2 p.

研究成果: Letter

Verbal Learning
Reproducibility of Results

Response to the letter from Dr. Veerman and colleagues

Kishi, T., Ikuta, T., Matsuda, Y. & Iwata, N., 01-12-2017, : : Psychopharmacology. 234, 23-24, p. 3537-3538 2 p.

研究成果: Letter

3 引用 (Scopus)

Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population

Members of the Clozapine Pharmacogenomics Consortium of Japan are the following, 01-07-2017, : : Biological Psychiatry. 82, 1, p. e9-e10

研究成果: Letter

2 引用 (Scopus)

Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks

Sumiyoshi, T., Toyomaki, A., Kawano, N., Kitajima, T., Kusumi, I., Ozaki, N., Iwata, N., Sueyoshi, K. & Nakagome, K., 08-2017, : : Psychiatry and clinical neurosciences. 71, 8, p. 570-571 2 p.

研究成果: Letter

Bipolar Disorder
Learning
2016
12 引用 (Scopus)

Genome-wide environment interaction between depressive state and stressful life events

Ikeda, M., Shimasaki, A., Takahashi, A., Kondo, K., Saito, T., Kawase, K., Esaki, K., Otsuka, Y., Mano, K., Kubo, M. & Iwata, N., 01-2016, : : Journal of Clinical Psychiatry. 77, 1, p. e29-e30

研究成果: Letter

Gene-Environment Interaction
Life Change Events
Single Nucleotide Polymorphism
Young Adult
Genotype
9 引用 (Scopus)

Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility

Kimura, H., Wang, C., Ishizuka, K., Xing, J., Takasaki, Y., Kushima, I., Aleksic, B., Uno, Y., Okada, T., Ikeda, M., Mori, D., Inada, T., Iwata, N. & Ozaki, N., 01-12-2016, : : Schizophrenia Research. 178, 1-3, p. 104-106 3 p.

研究成果: Letter

7 引用 (Scopus)

Polygenetic components for schizophrenia, bipolar disorder and rheumatoid arthritis predict risk of schizophrenia

Ohi, K., Kikuchi, M., Ikeda, M., Yamamori, H., Yasuda, Y., Fujimoto, M., Fujino, H., Miura, K., Fukunaga, M., Nakaya, A., Iwata, N. & Hashimoto, R., 01-08-2016, : : Schizophrenia Research. 175, 1-3, p. 226-229 4 p.

研究成果: Letter

Bipolar Disorder
Rheumatoid Arthritis
Schizophrenia
REM Sleep Behavior Disorder
Clonazepam
Meta-Analysis
Alzheimer Disease
Therapeutics
2015
7 引用 (Scopus)

Genetic overlap between antipsychotic response and susceptibility to schizophrenia

Ikeda, M., Yoshimura, R., Hashimoto, R., Kondo, K., Saito, T., Shimasaki, A., Ohi, K., Tochigi, M., Kawamura, Y., Nishida, N., Miyagawa, T., Sasaki, T., Tokunaga, K., Kasai, K., Takeda, M., Nakamura, J., Ozaki, N. & Iwata, N., 01-02-2015, : : Journal of Clinical Psychopharmacology. 35, 1, p. 85-88 4 p.

研究成果: Letter

No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants

Hatano, M., Ikeda, M., Kondo, K., Saito, T., Shimasaki, A., Esaki, K., Umene-Nakano, W., Yoshimura, R., Nakamura, J., Ozaki, N. & Iwata, N., 26-06-2015, : : Journal of Human Genetics. 60, 6, p. 343-344 2 p.

研究成果: Letter

2014
12 引用 (Scopus)

Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume

Ohi, K., Hashimoto, R., Ikeda, M., Yamashita, F., Fukunaga, M., Nemoto, K., Ohnishi, T., Yamamori, H., Yasuda, Y., Fujimoto, M., Umeda-Yano, S., Watanabe, Y., Iwata, N., Weinberger, D. R. & Takeda, M., 01-01-2014, : : Cortex. 58, p. 23-26 4 p.

研究成果: Letter

Organ Size
Genetic Association Studies
Temporal Lobe
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
1 引用 (Scopus)

No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia

Kishi, T., Fukuo, Y., Moriwaki, M., Iwata, N., Hori, H., Yoshimura, R., Katsuki, A., Ikenouchi-Sugita, A., Atake, K., Umene-Nakano, W., Nakamura, J., Kaneda, Y. & Fujita, K., 30-03-2014, : : Psychiatry Research. 215, 3, p. 803-805 3 p.

研究成果: Letter

Cognition Disorders
Neuropsychological Tests
Brain-Derived Neurotrophic Factor
Reverse Transcriptase Polymerase Chain Reaction
Cognition
1 引用 (Scopus)

Periodic abdominal movements.

Esaki, Y., Kitajima, T., Tsuchiya, A., Hirose, M., Torii, Y., Fujita, S. & Iwata, N., 02-2014, : : Psychiatry and clinical neurosciences. 68, 2, 1 p.

研究成果: Letter

Restless Legs Syndrome
Abdomen
3 引用 (Scopus)

The position of blonanserin as a treatment for schizophrenia

Kishi, T., Matsuda, Y. & Iwata, N., 01-12-2014, : : Asia-Pacific Psychiatry. 6, 4, 1 p.

研究成果: Letter

Piperazines
Piperidines
Double-Blind Method
Antipsychotic Agents
Schizophrenia
6 引用 (Scopus)

Variant GADL1 and response to lithium in bipolar I disorder[2]

Ikeda, M., Kondo, K. & Iwata, N., 01-01-2014, : : New England Journal of Medicine. 370, 19, p. 1856-1857 2 p.

研究成果: Letter

Antimanic Agents
Carboxy-Lyases
Bipolar Disorder
Lithium
Single Nucleotide Polymorphism
2013
6 引用 (Scopus)

An association analysis of the cardiomyopathy-associated 5 (CMYA5) gene with schizophrenia in a Japanese population

Furukawa, M., Tochigi, M., Otowa, T., Arinami, T., Inada, T., Ujike, H., Watanabe, Y., Iwata, N., Itokawa, M., Kunugi, H., Hashimoto, R., Ozaki, N., Kakiuchi, C., Kasai, K. & Sasaki, T., 01-08-2013, : : Psychiatric Genetics. 23, 4, p. 179-180 2 p.

研究成果: Letter

Muscle Proteins
Genetic Association Studies
Genetic Predisposition to Disease
Cardiomyopathies
Single Nucleotide Polymorphism
16 引用 (Scopus)
Memantine
Amantadine
N-Methyl-D-Aspartate Receptors
Antipsychotic Agents
Meta-Analysis
3 引用 (Scopus)

Efficacy and tolerability of high dose olanzapine in Japanese patients with treatment-resistant schizophrenia

Kishi, T., Suzuki, T., Sekiguchi, H., Moriwaki, M., Okuda, A., Mekata, T., Hattori, M., Tsunoka, T., Chekuri, R., Musso, G. M., Fujita, K. & Iwata, N., 01-02-2013, : : Asian Journal of Psychiatry. 6, 1, p. 86-87 2 p.

研究成果: Letter

olanzapine
Benzodiazepines
Antipsychotic Agents
Schizophrenia
Japan
1 引用 (Scopus)

Further evidence of an association between a genetic variant in BMP7 and treatment response to SSRIs in major depressive disorder

Esaki, K., Kondo, K., Hatano, M., Saito, T., Kishi, T., Umene-Nakano, W., Yoshimura, R., Nakamura, J., Ozaki, N., Ikeda, M. & Iwata, N., 01-08-2013, : : Journal of Human Genetics. 58, 8, p. 568-569 2 p.

研究成果: Letter

Bone Morphogenetic Protein 7
Major Depressive Disorder
Serotonin Uptake Inhibitors
Genetic Association Studies
Single Nucleotide Polymorphism
26 引用 (Scopus)

Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population

Ikeda, M., Aleksic, B., Yamada, K., Iwayama-Shigeno, Y., Matsuo, K., Numata, S., Watanabe, Y., Ohnuma, T., Kaneko, T., Fukuo, Y., Okochi, T., Toyota, T., Hattori, E., Shimodera, S., Itakura, M., Nunokawa, A., Shibata, N., Tanaka, H., Yoneda, H., Arai, H. および5人, Someya, T., Ohmori, T., Yoshikawa, T., Ozaki, N. & Iwata, N., 01-06-2013, : : Molecular Psychiatry. 18, 6, p. 636-638 3 p.

研究成果: Letter

Proto-Oncogene Proteins
Notch Receptors
Genome-Wide Association Study
Linkage Disequilibrium
Genetic Association Studies
9 引用 (Scopus)

Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia

Watanabe, Y., Iijima, Y., Egawa, J., Nunokawa, A., Kaneko, N., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Itokawa, M., Sasaki, T., Ozaki, N., Hashimoto, R., Shibuya, M., Igeta, H. & Someya, T., 01-11-2013, : : Schizophrenia Research. 150, 2-3, p. 596-597 2 p.

研究成果: Letter

Genetic Association Studies
Genetic Predisposition to Disease
MicroRNAs
Gene Frequency
Single Nucleotide Polymorphism
2012
3 引用 (Scopus)

A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population

Watanabe, Y., Egawa, J., Iijima, Y., Nunokawa, A., Kaneko, N., Shibuya, M., Arinami, T., Ujike, H., Inada, T., Iwata, N., Tochigi, M., Kunugi, H., Itokawa, M., Ozaki, N., Hashimoto, R. & Someya, T., 01-05-2012, : : Schizophrenia Research. 137, 1-3, p. 264-266 3 p.

研究成果: Letter

Tryptophan Hydroxylase
Genetic Association Studies
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Case-Control Studies
2010
9 引用 (Scopus)

Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome

Ikeda, M., Williams, N., Williams, H. J., Smith, R., Monks, S., Owen, M. J., Murphy, K. C. & O'Donovan, M. C., 01-06-2010, : : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153, 4, p. 980-982 3 p.

研究成果: Letter

DiGeorge Syndrome
Psychotic Disorders
4 引用 (Scopus)

No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study

Ohnuma, T., Shibata, N., Baba, H., Ohi, K., Yasuda, Y., Nakamura, Y., Okochi, T., Naitoh, H., Hashimoto, R., Iwata, N., Ozaki, N., Takeda, M. & Arai, H., 01-05-2010, : : Schizophrenia Research. 118, 1-3, p. 300-302 3 p.

研究成果: Letter

DNA Mutational Analysis
D-Amino-Acid Oxidase
Multicenter Studies
Single Nucleotide Polymorphism
Schizophrenia
2008
4 引用 (Scopus)

Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia

Nunokawa, A., Watanabe, Y., Kitamura, H., Kaneko, N., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Itokawa, M., Ozaki, N. & Someya, T., 01-04-2008, : : Psychiatry and clinical neurosciences. 62, 2, p. 239-240 2 p.

研究成果: Letter

Metabotropic Glutamate Receptors
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Case-Control Studies
Schizophrenia
7 引用 (Scopus)

Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia

Ishiguro, H., Imai, K., Koga, M., Horiuchi, Y., Inada, T., Iwata, N., Ozaki, N., Ujike, H., Itokawa, M., Kunugi, H., Sasaki, T., Watanabe, Y., Someya, T. & Arinami, T., 01-10-2008, : : Psychiatric Genetics. 18, 5, p. 255-256 2 p.

研究成果: Letter

22q11 Deletion Syndrome
Chromosomes, Human, Pair 22
Chromosome Deletion
Single Nucleotide Polymorphism
Schizophrenia
2007
30 引用 (Scopus)

Support for association of the PPP3CC gene with schizophrenia [1]

Horiuchi, Y., Ishiguro, H., Koga, M., Inada, T., Iwata, N., Ozaki, N., Ujike, H., Muratake, T., Someya, T. & Arinami, T., 01-10-2007, : : Molecular Psychiatry. 12, 10, p. 891-893 3 p.

研究成果: Letter

Calcineurin
Protein Subunits
Genetic Predisposition to Disease
Gene Frequency
Single Nucleotide Polymorphism
2005
20 引用 (Scopus)

A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men [6]

Hashimoto, R., Yoshida, M., Ozaki, N., Yamanouchi, Y., Iwata, N., Suzuki, T., Kitajima, T., Tatsumi, M., Kamijima, K. & Kunugi, H., 01-03-2005, : : Schizophrenia Research. 73, 2-3, p. 383-385 3 p.

研究成果: Letter

Chimerin Proteins
rho GTP-Binding Proteins
Chromosomes, Human, Pair 7
DNA Primers
Missense Mutation