生理化学

2023

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease

Nagatsu, T., Nakashima, A., Watanabe, H., Ito, S., Wakamatsu, K., Zucca, F. A., Zecca, L., Youdim, M., Wulf, M., Riederer, P. & Dijkstra, J. M., 05-2023, In: Journal of Neural Transmission. 130, 5, p. 611-625 15 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

Open Access

28 被引用数 (Scopus)

2022

Characterization of Hypothalamic MCH Neuron Development in a 3D Differentiation System of Mouse Embryonic Stem Cells

Kodani, Y., Kawata, M., Suga, H., Kaneko, Y. S., Nakashima, A., Kameyama, T., Saito, K. & Nagasaki, H., 01-03-2022, In: eNeuro. 9, 2, ENEURO.0442-21.2022.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids

Kodani, Y., Kawata, M., Suga, H., Kasai, T., Ozone, C., Sakakibara, M., Kuwahara, A., Taga, S., Arima, H., Kameyama, T., Saito, K., Nakashima, A. & Nagasaki, H., 12-07-2022, In: Frontiers in Endocrinology. 13, 941166.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Long-range axonal projections of transplanted mouse embryonic stem cell-derived hypothalamic neurons into adult mouse brain

Kawata, M., Kodani, Y., Ohkuma, M., Miyachi, E. I., Kaneko, Y. S., Nakashima, A., Suga, H., Kameyama, T., Saito, K. & Nagasaki, H., 11-2022, In: PloS one. 17, 11 November, e0276694.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Monoamine Oxidase Inhibitor (MAO-I)-Mediated Neuroprotection for Treating Parkinson’s Disease

Nagatsu, T. & Nakashima, A., 01-01-2022, NeuroPsychopharmacotherapy. Springer International Publishing, p. 3127-3147 21 p.

研究成果: 書籍/レポートタイプへの寄稿 › 章

1 被引用数 (Scopus)

Parkinsonian Drugs

Nagatsu, T. & Nakashima, A., 01-01-2022, NeuroPsychopharmacotherapy. Springer International Publishing, p. 2821 1 p.

研究成果: 書籍/レポートタイプへの寄稿 › 前書き/後書き

2020

NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity

Nakashima, A., Yamaguchi, H., Kondo, M., Furumura, T., Kodani, Y., Kaneko, Y. S., Kawata, M., Nagasaki, H., Nagatsu, T. & Ota, A., 12-2020, In: Journal of Neural Transmission. 127, 12, p. 1631-1640 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

2019

Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells

Nakashima, A., Yamaguchi, H., Kodani, Y., Kaneko, Y. S., Kawata, M., Nagasaki, H., Nagatsu, T. & Ota, A., 03-09-2019, In: Biochemical and Biophysical Research Communications. 516, 4, p. 1060-1065 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

2018

Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

Nakashima, A., Kodani, Y., Kaneko, Y. S., Nagasaki, H. & Ota, A., 01-01-2018, In: Journal of Neural Transmission. 125, 1, p. 9-15 7 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

7 被引用数 (Scopus)

2015

Aripiprazole increases NAD(P)H–quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells

Kaneko, Y. S., Takayanagi, T., Nagasaki, H., Kodani, Y., Nakashima, A., Mori, K., Suzuki, A., Itoh, M., Kondo, K., Nagatsu, T., Ota, M. & Ota, A., 01-06-2015, In: Journal of Neural Transmission. 122, 6, p. 757-772 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G₁ phase and protects them from UV light-induced apoptosis

Kaneko, Y. S., Ota, A., Nakashima, A., Nagasaki, H., Kodani, Y., Mori, K. & Nagatsu, T., 02-2015, In: Journal of Neural Transmission. 122, 2, p. 187-199 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide

Takayanagi, T., S., Y. K., Nagasaki, H., Kodani, Y., Nakashima, A., Mori, K., Suzuki, A., Itoh, M., Kondo, K., Nagatsu, T., Ota, M. & Ota, A., 2015, In: Fujita Medical Journal. 1, 1, p. 1-5 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2014

Aripiprazole increases NADPH level in PC12 cells: The role of NADPH oxidase

Nagasaki, H., Nakashima, A., Kaneko, Y. S., Kodani, Y., Takayanagi, T., Itoh, M., Kondo, K., Nagatsu, T., Hamada, Y., Ota, M. & Ota, A., 01-2014, In: Journal of Neural Transmission. 121, 1, p. 91-103 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

2013

A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: A contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer

Nakashima, A., Ota, A., Kaneko, Y. S., Mori, K., Nagasaki, H. & Nagatsu, T., 01-2013, In: Journal of Neural Transmission. 120, 1, p. 49-54 6 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

29 被引用数 (Scopus)

Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme

Nakashima, A., Kaneko, Y. S., Mori, K., Nagasaki, H., Nagatsu, T. & Ota, A., 12-2013, Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. Elsevier Inc., p. 11-12 2 p.

研究成果: 書籍/レポートタイプへの寄稿 › 章

Intracellular stability of tyrosine hydroxylase. Phosphorylation and proteasomal digestion of the enzyme.

Nakashima, A., Kaneko, Y. S., Kodani, Y., Mori, K., Nagasaki, H., Nagatsu, T. & Ota, A., 2013, Advances in Pharmacology. Academic Press Inc., p. 3-11 9 p. (Advances in Pharmacology; vol. 68).

研究成果: 書籍/レポートタイプへの寄稿 › 章

17 被引用数 (Scopus)

2012

Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells

Ota, A., Nakashima, A., Kaneko, Y. S., Mori, K., Nagasaki, H., Takayanagi, T., Itoh, M., Kondo, K., Nagatsu, T. & Ota, M., 11-2012, In: Journal of Neural Transmission. 119, 11, p. 1327-1342 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

Microglial activation in neuroinflammation: Implications for the etiology of neurodegeneration

Kaneko, Y. S., Nakashima, A., Mori, K., Nagatsu, T., Nagatsu, I. & Ota, A., 04-2012, In: Neurodegenerative Diseases. 10, 1-4, p. 100-103 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

Proteasomal degradation of tyrosine hydroxylase and neurodegeneration

Nakashima, A., 01-2012, In: Journal of neurochemistry. 120, 2, p. 199-201 3 p.

研究成果: ジャーナルへの寄稿 › 編集 › 査読

Open Access

10 被引用数 (Scopus)

Regulation of oxidative stress in long-lived lipopolysaccharide-activated microglia

Kaneko, Y. S., Ota, A., Nakashima, A., Mori, K., Nagatsu, I. & Nagatsu, T., 07-2012, In: Clinical and Experimental Pharmacology and Physiology. 39, 7, p. 599-607 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

Subventricular zone under the neuroinflammatory stress and Parkinson's disease

Mori, K., Kaneko, Y. S., Nakashima, A., Nagasaki, H., Nagatsu, T., Nagatsu, I. & Ota, A., 07-2012, In: Cellular and molecular neurobiology. 32, 5, p. 777-785 9 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

5 被引用数 (Scopus)

2011

Trial of integrated laboratory practice

Matsuo, O., Takahashi, Y., Abe, C., Tanaka, K., Nakashima, A. & Morita, H., 06-2011, In: American Journal of Physiology - Advances in Physiology Education. 35, 2, p. 237-240 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

2010

Effects of atypical antipsychotics and haloperidol on PC12 cells: Only aripiprazole phosphorylates AMP-activated protein kinase

Takami, G., Ota, M., Nakashima, A., Kaneko, Y. S., Mori, K., Nagatsu, T. & Ota, A., 10-2010, In: Journal of Neural Transmission. 117, 10, p. 1139-1153 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

Peripherally injected lipopolysaccharide induces apoptosis in the subventricular zone of young adult mice

Mori, K., Kaneko, Y. S., Nakashima, A., Nagatsu, T., Nagatsu, I. & Ota, A., 09-2010, In: Neuroscience Letters. 481, 2, p. 126-130 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

2009

Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia

Kaneko, Y. S., Nakashima, A., Mori, K., Nagatsu, T., Nagatsu, I. & Ota, A., 07-07-2009, In: Brain Research. 1279, p. 9-20 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines

Nakashima, A., Hayashi, N., Kaneko, Y. S., Mori, K., Sabban, E. L., Nagatsu, T. & Ota, A., 11-2009, In: Journal of Neural Transmission. 116, 11, p. 1355-1362 8 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

58 被引用数 (Scopus)

2008

Peripheral lipopolysaccharide administration affects the olfactory dopamine system in mice

Ota, A., Mori, K., Kaneko, Y. S., Nakashima, A., Nagatsu, I. & Nagatsu, T., 12-2008, Stress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms. Blackwell Publishing Inc., p. 127-135 9 p. (Annals of the New York Academy of Sciences; vol. 1148).

研究成果: 書籍/レポートタイプへの寄稿 › 会議への寄与

9 被引用数 (Scopus)

2007

Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice

Ota, A., Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I. & Nagatsu, T., 06-2007, In: Stress. 10, 2, p. 131-136 6 p.

研究成果: ジャーナルへの寄稿 › 総説 › 査読

25 被引用数 (Scopus)

Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells

Ota, M., Nakashima, A., Kaneko, Y. S., Mori, K., Takami, G. & Ota, A., 02-02-2007, In: Neuroscience Letters. 412, 3, p. 254-258 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

RNAi of 14-3-3η protein increases intracellular stability of tyrosine hydroxylase

Nakashima, A., Hayashi, N., Kaneko, Y. S., Mori, K., Sabban, E. L., Nagatsu, T. & Ota, A., 23-11-2007, In: Biochemical and Biophysical Research Communications. 363, 3, p. 817-821 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

2006

Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates

Mazzulli, J. R., Mishizen, A. J., Giasson, B. I., Lynch, D. R., Thomas, S. A., Nakashima, A., Nagatsu, T., Ota, A. & Ischiropoulos, H., 27-09-2006, In: Journal of Neuroscience. 26, 39, p. 10068-10078 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

139 被引用数 (Scopus)

2005

Corticotropin-releasing factor receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression at murine locus coeruleus

Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I., Nagatsu, T. & Ota, A., 2005, In: Biogenic Amines. 19, 4-6, p. 289-297 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells

Nakashima, A., Hayashi, N., Kaneko, Y. S., Mori, K., Egusa, H., Nagatsu, T. & Ota, A., 01-07-2005, In: Journal of Neuroscience Research. 81, 1, p. 110-120 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

mRNA expression levels of leptin-related substances can be modified in risperidone-injected rats

Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Takami, G. & Ota, A., 2005, In: Biogenic Amines. 19, 4-6, p. 299-308 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: Possible role of increased norepinephrine turnover

Kaneko, Y. S., Mori, K., Nakashima, A., Sawada, M., Nagatsu, I. & Ota, A., 07-2005, In: Journal of neurochemistry. 94, 2, p. 393-404 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

29 被引用数 (Scopus)

Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb

Mori, K., Kaneko, Y. S., Nakashima, A., Nagatsu, I., Takahashi, H. & Ota, A., 28-03-2005, In: Brain Research. 1039, 1-2, p. 116-129 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

Resistance to excessive bodyweight gain in risperidone-injected rats

Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Takahashi, H. & Ota, A., 04-2005, In: Clinical and Experimental Pharmacology and Physiology. 32, 4, p. 279-287 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

The phosphorylation of Ser⁴⁰ of tyrosine hydroxylase has no effect on the stability of the enzyme in PC12 cells

Nakashima, A., Kaneko, Y. S., Mori, K., Nagatsu, T. & Ota, A., 2005, In: Biogenic Amines. 19, 4-6, p. 279-288 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2004

Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide

Fujiwara, K., Mori, K., Kaneko, Y. S., Nakashima, A., Nagasaka, A., Itoh, M. & Ota, A., 24-02-2004, In: Biochimica et Biophysica Acta - General Subjects. 1670, 3, p. 181-198 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

2003

Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus

Mori, K., Kaneko, Y. S., Nakashima, A., Fujiwara, K., Nagatsu, I. & Ota, A., 01-01-2003, In: Journal of Neural Transmission. 110, 1, p. 31-50 20 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription

Nakashima, A., Ota, A. & Sabban, E. L., 10-04-2003, In: Molecular Brain Research. 112, 1-2, p. 61-69 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

53 被引用数 (Scopus)

Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus

Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I. & Ota, A., 15-01-2003, In: Neuroscience. 116, 1, p. 7-12 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

Peripheral injection of risperidone, an atypical antipsychotic, alters the body weight gain of rats (multiple letters)

Goudie, A. J., Halford, J. C. G., Cooper, G. D., Dovey, T., Pickavance, L. C., Wilding, J. P. H., Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Ota, A., Fujiwara, K., Itoh, M. & Nagasaka, A., 07-2003, In: Clinical and Experimental Pharmacology and Physiology. 30, 7, p. 513-514 2 p.

研究成果: ジャーナルへの寄稿 › Letter › 査読

2002

Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus

Serova, L., Rivkin, M., Nakashima, A. & Sabban, E. L., 2002, In: Neuroendocrinology. 75, 3, p. 193-200 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

112 被引用数 (Scopus)

Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats

Ota, M., Mori, K., Nakashima, A., Kaneko, Y. S., Fujiwara, K., Itoh, M., Nagasaka, A. & Ota, A., 2002, In: Clinical and Experimental Pharmacology and Physiology. 29, 11, p. 980-989 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

58 被引用数 (Scopus)

2001

Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection

Kaneko, Y. S., Mori, K., Nakashima, A., Nagatsu, I., Nagatsu, T. & Ota, A., 2001, In: Brain Research Protocols. 8, 1, p. 25-31 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

Exon 3 of tyrosine hydroxylase gene: Lack of association with Japanese schizophrenic patients

Ota, M., Nakashima, A., Ikemoto, K., Nojima, S., Tanaka, M., Okuda, M., Koga, H., Mori, K., Kaneko, Y. S., Fujiwara, K., Yamamoto, H., Nagatsu, T. & Ota, A., 2001, In: Molecular Psychiatry. 6, 3, p. 315-319 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

9 被引用数 (Scopus)

Expression of GTP cyclohydrolase I in murine locus ceruleus is enhanced by peripheral administration of lipopolysaccharide

Kaneko, Y. S., Ikemoto, K., Mori, K., Nakashima, A., Nagatsu, I. & Ota, A., 02-02-2001, In: Brain Research. 890, 2, p. 203-210 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

1999

Dopamine inhibition of human tyrosine hydroxylase type 1 is controlled by the specific portion in the N-terminus of the enzyme

Nakashima, A., Mori, K., Suzuki, T., Kurita, H., Otani, M., Nagatsu, T. & Ota, A., 1999, In: Journal of neurochemistry. 72, 5, p. 2145-2153 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

40 被引用数 (Scopus)

Expression of human tyrosine hydroxylase type I in Escherichia coli as a protease-cleavable fusion protein

Nakashima, A., Mori, K., Nagatsu, T. & Ota, A., 1999, In: Journal of Neural Transmission. 106, 9-10, p. 819-824 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

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