医学部

研究成果 1975 2020

2019

Prognosis of pulmonary fibrosis presenting with a usual interstitial pneumonia pattern on computed tomography in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis: A retrospective single-center study

Watanabe, T., Minezawa, T., Hasegawa, M., Goto, Y., Okamura, T., Sakakibara, Y., Niwa, Y., Kato, A., Hayashi, M., Isogai, S., Kondo, M., Yamamoto, N., Hashimoto, N. & Imaizumi, K., 01-11-2019, : : BMC pulmonary medicine. 19, 1, 194.

研究成果: Article

公開
Antineutrophil Cytoplasmic Antibodies
Idiopathic Pulmonary Fibrosis
Nephritis
Pulmonary Fibrosis
Peroxidase

Prostate stem cell antigen gene polymorphism is associated with H. Pylori–related promoter DNA methylation in nonneoplastic gastric epithelium

Tahara, T., Tahara, S., Horiguchi, N., Kato, T., Shinkai, Y., Okubo, M., Terada, T., Yoshida, D., Funasaka, K., Nagasaka, M., Nakagawa, Y., Kurahashi, H., Shibata, T., Tsukamoto, T. & Ohmiya, N., 01-01-2019, : : Cancer Prevention Research. 12, 9, p. 579-584 6 p.

研究成果: Article

DNA Methylation
Prostate
Stomach
Stem Cells
Epithelium

Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events

Hasegawa, M., Hatayama, T., Kondo, A., Nagahiro, S., Fujimaki, T., Amagasaki, K., Arita, K., Date, I., Fujii, Y., Goto, T., Hanaya, R., Higuchi, Y., Hongo, K., Inoue, T., Kasuya, H., Kayama, T., Kawashima, M., Kohmura, E., Maehara, T., Matsushima, T. および16人, Mizobuchi, Y., Morita, A., Nishizawa, S., Noro, S., Saito, S., Shimano, H., Shirane, R., Takeshima, H., Tanaka, Y., Tanabe, H., Toda, H., Yamakami, I., Nishiyama, Y., Ohba, S., Hirose, Y. & Suzuki, T., 10-2019, : : World Neurosurgery. 130, p. e251-e258

研究成果: Article

Microvascular Decompression Surgery
Polytetrafluoroethylene
Prostheses and Implants
Japan
Reoperation

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)

iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium, 01-06-2019, : : Nature Genetics. 51, 6, 1 p.

研究成果: Comment/debate

公開
Genomics
Psychiatry
Schizophrenia
Gene Expression
Brain
5 引用 (Scopus)

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells

Sakamoto, A., Kunou, S., Shimada, K., Tsunoda, M., Aoki, T., Iriyama, C., Tomita, A., Nakamura, S., Hayakawa, F. & Kiyoi, H., 01-2019, : : Cancer science. 110, 1, p. 269-278 10 p.

研究成果: Article

Pyruvic Acid
Lymphoma
Survival
Cell Survival
Citric Acid Cycle

Quetiapine extended-release vs olanzapine for Japanese patients with bipolar depression: A Bayesian analysis

Kishi, T., Ikuta, T., Matsuda, Y. & Iwata, N., 01-09-2019, : : Neuropsychopharmacology reports. 39, 3, p. 256-259 4 p.

研究成果: Article

公開
olanzapine
Bayes Theorem
Bipolar Disorder
Odds Ratio
Depression

Randomized Controlled Trial of Gait Training Using Gait Exercise Assist Robot (GEAR) in Stroke Patients with Hemiplegia

Tomida, K., Sonoda, S., Hirano, S., Suzuki, A., Tanino, G., Kawakami, K., Saito, E. & Kagaya, H., 01-09-2019, : : Journal of Stroke and Cerebrovascular Diseases. 28, 9, p. 2421-2428 8 p.

研究成果: Article

Hemiplegia
Gait
Randomized Controlled Trials
Stroke
Exercise

Rare compound heterozygous missense SPATA7 variations and risk of schizophrenia; whole-exome sequencing in a consanguineous family with affected siblings, follow-up sequencing and a casecontrol study

Igeta, H., Watanabe, Y., Morikawa, R., Ikeda, M., Otsuka, I., Hoya, S., Koizumi, M., Egawa, J., Hishimoto, A., Iwata, N. & Someya, T., 01-01-2019, : : Neuropsychiatric Disease and Treatment. 15, p. 2353-2363 11 p.

研究成果: Article

公開
Exome
Siblings
Schizophrenia
Case-Control Studies
Parents
公開
Return to Work
Japan
Neoplasms
Selection Bias
Confounding Factors (Epidemiology)

Reduced ceftazidime and ertapenem susceptibility due to production of OXA-2 in Klebsiella pneumoniae ST258

Iovleva, A., Mettus, R. T., McElheny, C. L., Mustapha, M. M., Van Tyne, D., Shields, R. K., Pasculle, A. W., Cooper, V. S. & Doi, Y., 01-08-2019, : : The Journal of antimicrobial chemotherapy. 74, 8, p. 2203-2208 6 p.

研究成果: Article

Ceftazidime
Klebsiella pneumoniae
meropenem
Plasmids
Integrons
公開
Carnitine
Hypoglycemia
Diet Therapy
Meat Products
Dairy Products

Relationship between history of ischemic stroke and all-cause mortality in incident dialysis patients

Kojima, M., Inaguma, D., Koide, S., Koshi-Ito, E., Takahashi, K., Hayashi, H., Tsuboi, N., Hasegawa, M. & Yuzawa, Y., 01-09-2019, : : Nephron. 143, 1, p. 43-53 11 p.

研究成果: Article

公開
Dialysis
Stroke
Mortality
Propensity Score
Cohort Studies
1 引用 (Scopus)
Antihypertensive Agents
Dialysis
Cohort Studies
Prospective Studies
Mortality
4 引用 (Scopus)

Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder

Nguyen, L. H., Kakeda, S., Katsuki, A., Sugimoto, K., Otsuka, Y., Ueda, I., Igata, R., Watanabe, K., Kishi, T., Iwata, N., Korogi, Y. & Yoshimura, R., 01-10-2019, : : European Archives of Psychiatry and Clinical Neuroscience. 269, 7, p. 785-794 10 p.

研究成果: Article

Major Depressive Disorder
Vascular Endothelial Growth Factor A
Single Nucleotide Polymorphism
Brain
Genotype
3 引用 (Scopus)
Albuminuria
Chronic Renal Insufficiency
Meta-Analysis
Glomerular Filtration Rate
Bicarbonates
Human Herpesvirus 3
Chickenpox
Real-Time Polymerase Chain Reaction
DNA
Point-of-Care Systems

Repetitive Peripheral Magnetic Stimulation for Strengthening of the Suprahyoid Muscles: A Randomized Controlled Trial

Ogawa, M., Kagaya, H., Nagashima, Y., Mori, S., Shibata, S., Inamoto, Y., Aoyagi, Y., Toda, F., Ozeki, M. & Saitoh, E., 01-01-2019, (Accepted/In press) : : Neuromodulation.

研究成果: Article

Randomized Controlled Trials
Muscles
Head
Upper Esophageal Sphincter
Hyoid Bone

Response to Hamann et al

Suzuki, K., Yagami, A., Ito, A., Kanto, H. & Matsunaga, K., 08-2019, : : Contact Dermatitis. 81, 2, 1 p.

研究成果: Letter

Response to the Letter from Dr. Jacob Peedicayil

Sakuma, K., Kishi, T. & Iwata, N., 01-04-2019, : : Psychopharmacology. 236, 4, p. 1403-1404 2 p.

研究成果: Letter

Retraction: Preventive effects of risedronate and calcitriol on cancellous osteopenia in rats treated with high-dose glucocorticoid

Iwamoto, J., Seki, A., Takeda, T., Sato, Y., Yamada, H., Shen, C. L. & Yeh, J. K., 01-01-2019, : : Experimental animals. 68, 3, p. R2

研究成果: Comment/debate

公開
osteopenia
calcitriol
Calcitriol
Metabolic Bone Diseases
glucocorticoids

Risedronate Attenuates Podocyte Injury in Phosphate Transporter-Overexpressing Rats

Asada, Y., Takayanagi, T., Kawakami, T., Tomatsu, E., Masuda, A., Yoshino, Y., Sekiguchi-Ueda, S., Shibata, M., Ide, T., Niimi, H., Yaoita, E., Seino, Y., Sugimura, Y. & Suzuki, A., 01-01-2019, : : International Journal of Endocrinology. 2019, 4194853.

研究成果: Article

公開
Phosphate Transport Proteins
Podocytes
Wounds and Injuries
Chronic Kidney Disease-Mineral and Bone Disorder
Glomerular Basement Membrane

Risk, Recovery, and Clinical Impact of Neurological Complications in Adult Spinal Deformity Surgery

Yagi, M., Michikawa, T., Hosogane, N., Fujita, N., Okada, E., Suzuki, S., Tsuji, O., Nagoshi, N., Asazuma, T., Tsuji, T., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-10-2019, : : Spine. 44, 19, p. 1364-1370 7 p.

研究成果: Article

Activities of Daily Living
Quality of Life
Ambulatory Surgical Procedures
Spinal Cord Injuries
Hospitalization

Risk stratification for cardiac mortality using electrocardiographic markers based on 24-hour Holter recordings: the JANIES-SHD study

Kinoshita, T., Hashimoto, K., Yoshioka, K., Miwa, Y., Yodogawa, K., Watanabe, E., Nakamura, K., Nakagawa, M., Nakamura, K., Watanabe, T., Yusu, S., Tachibana, M., Nakahara, S., Mizumaki, K. & Ikeda, T., 01-01-2019, (Accepted/In press) : : Journal of cardiology. 75, 2, p. 155-163 9 p.

研究成果: Article

Heart Diseases
Mortality
Ventricular Tachycardia
Heart Rate
Stroke Volume

SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation

Kuroda, T., Yasuda, S., Tachi, S., Matsuyama, S., Kusakawa, S., Tano, K., Miura, T., Matsuyama, A. & Sato, Y., 01-12-2019, : : Nature Communications. 10, 1, 2175.

研究成果: Article

公開
Induced Pluripotent Stem Cells
stem cells
Stem cells
Cell Differentiation
Ectoderm
16 引用 (Scopus)

Sarcopenia and dysphagia: Position paper by four professional organizations

Fujishima, I., Fujiu-Kurachi, M., Arai, H., Hyodo, M., Kagaya, H., Maeda, K., Mori, T., Nishioka, S., Oshima, F., Ogawa, S., Ueda, K., Umezaki, T., Wakabayashi, H., Yamawaki, M. & Yoshimura, Y., 01-02-2019, : : Geriatrics and Gerontology International. 19, 2, p. 91-97 7 p.

研究成果: Article

Sarcopenia
professional association
Deglutition Disorders
rehabilitation
Deglutition

Seaweed intake and risk of cardiovascular disease: The Japan Public Health Center-based Prospective (JPHC) Study

Murai, U., Yamagishi, K., Sata, M., Kokubo, Y., Saito, I., Yatsuya, H., Ishihara, J., Inoue, M., Sawada, N., Iso, H. & Tsugane, S., 01-12-2019, : : American Journal of Clinical Nutrition. 110, 6, p. 1449-1455 7 p.

研究成果: Article

Seaweed
Japan
Cardiovascular Diseases
Public Health
Myocardial Ischemia

Segmental dilatation of colon detected on prenatal ultrasound

Uga, N., Suzuki, T., Sakurai, K., Tsukamoto, T., Tsuchiya, T., Kondo, Y., Naoe, A., Watanabe, S., Yasui, T. & Hara, F., 01-06-2019, : : Journal of Pediatric Surgery Case Reports. 45, 101208.

研究成果: Article

公開
Dilatation
Colon
Prenatal Ultrasonography
Constipation
Descending Colon
1 引用 (Scopus)

Self-reported eczema in relation with mortality from cardiovascular disease in Japanese: The Japan collaborative cohort study

Nishida, Y., Kubota, Y., Iso, H., Tamakoshi, A., Tamakoshi, A., Mori, M., Kaneko, Y., Tsuji, I., Nakamura, Y., Iso, H., Yamagishi, K., Mikami, H., Kurosawa, M., Hoshiyama, Y., Tanabe, N., Tamakoshi, K., Wakai, K., Ando, M., Suzuki, K., Hashimoto, S. および12人, Yatsuya, H., Kikuchi, S., Wada, Y., Kawamura, T., Watanabe, Y., Ozasa, K., Mikami, K., Date, C., Sakata, K., Kurozawa, Y., Fujino, Y. & Shibata, A., 01-01-2019, : : Journal of atherosclerosis and thrombosis. 26, 9, p. 775-782 8 p.

研究成果: Article

公開
Eczema
Japan
Cohort Studies
Cardiovascular Diseases
Mortality
3 引用 (Scopus)

Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX

Okabe, A., Kiriyama, Y., Suzuki, S., Sakurai, K., Teramoto, A., Kato, H., Naiki-Ito, A., Tahara, S., Takahashi, S., Kuroda, M., Sugioka, A. & Tsukamoto, T., 01-01-2019, : : Journal of Toxicologic Pathology. 32, 2, p. 91-99 9 p.

研究成果: Article

公開
Double-Stranded DNA Breaks
Dimethylnitrosamine
Stomach
Pepsinogen A
Messenger RNA

Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice

Masuda, A., Seino, Y., Murase, M., Hidaka, S., Shibata, M., Takayanagi, T., Sugimura, Y., Hayashi, Y. & Suzuki, A., 05-2019, : : Nutrients. 11, 5, 1045.

研究成果: Article

公開
Protein-Restricted Diet
low protein diet
Starch
Weight Gain
weight gain
1 引用 (Scopus)

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease

Ozeki, T., Katsuno, T., Hayashi, H., Kato, S., Yasuda, Y., Ando, M., Tsuboi, N., Hagiwara, D., Arima, H. & Maruyama, S., 01-01-2019, : : American Journal of Nephrology. 49, 1, p. 54-63 10 p.

研究成果: Article

Lipoid Nephrosis
Steroids
Recurrence
Nephrotic Syndrome
Therapeutics
1 引用 (Scopus)

Simulated volume loss in the base of tongue in a virtual swallowing model

Wang, J., Ho, A. K., Papadopoulos-Nydam, G., Rieger, J., Inamoto, Y., Fels, S., Saitoh, E., Guo, C. & Aalto, D., 04-07-2019, : : Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization. 7, 4, p. 389-395 7 p.

研究成果: Article

Deglutition
Tongue
Deglutition Disorders
Oropharyngeal Neoplasms
Computer Simulation

Sleep duration and risk of breast cancer: The JACC Study

JACC Study Group, 28-02-2019, : : Breast Cancer Research and Treatment. 174, 1, p. 219-225 7 p.

研究成果: Article

Sleep
Breast Neoplasms
Parity
Confidence Intervals
Reproductive History
1 引用 (Scopus)

S-like-phase cyclin-dependent kinases stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription

Sato, Y., Watanabe, T., Suzuki, C., Abe, Y., Abdullah Al Masud, H. M., Inagaki, T., Yoshida, M., Suzuki, T., Goshima, F., Adachi, J., Tomonaga, T., Murata, T. & Kimura, H., 01-01-2019, : : Journal of Virology. 93, 8, Y.

研究成果: Article

Genetic Transcription
Human herpesvirus 4
cyclin-dependent kinase
Cyclin-Dependent Kinases
Human Herpesvirus 4

Smoking results in accumulation of ectopic fat in the liver

Kato, A., Li, Y., Ota, A., Naito, H., Yamada, H., Nihashi, T., Hotta, Y., Chiang, C., Hirakawa, Y., Aoyama, A., Tamakoshi, K. & Yatsuya, H., 01-01-2019, : : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 1075-1080 6 p.

研究成果: Article

公開
Smoking
Fats
Adiponectin
Liver
Triglycerides

Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010

Suzuki, H., Kadota, A., Okuda, N., Hayakawa, T., Nishi, N., Nakamura, Y., Arima, H., Miyagawa, N., Satoh, A., Miyamatsu, N., Yanagita, M., Yatsuya, H., Yamagata, Z., Ohkubo, T., Okamura, T., Ueshima, H., Okayama, A. & Miura, K., 28-05-2019, : : Environmental Health and Preventive Medicine. 24, 1, 37.

研究成果: Article

公開
Life Style
Odds Ratio
Depression
Confidence Intervals
Psychiatry
3 引用 (Scopus)

Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome

Ishihara, S., Fujita, N., Azuma, K., Michikawa, T., Yagi, M., Tsuji, T., Takayama, M., Matsumoto, H., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-03-2019, : : Spine Journal. 19, 3, p. 493-500 8 p.

研究成果: Article

Lipomatosis
Fats
Intra-Abdominal Fat
Subcutaneous Fat
Odds Ratio
1 引用 (Scopus)

Spinal fractures in patients with diffuse idiopathic skeletal hyperostosis: Clinical characteristics by fracture level

Okada, E., Shimizu, K., Kato, M., Fukuda, K., Kaneko, S., Ogawa, J., Yagi, M., Fujita, N., Tsuji, O., Suzuki, S., Nagoshi, N., Tsuji, T., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-05-2019, : : Journal of Orthopaedic Science. 24, 3, p. 393-399 7 p.

研究成果: Article

Diffuse Idiopathic Skeletal Hyperostosis
Spinal Fractures
Wounds and Injuries
Spine
Ankylosis
1 引用 (Scopus)

Spinal fractures in patients with Diffuse idiopathic skeletal hyperostosis:A nationwide multi-institution survey

Okada, E., Yoshii, T., Yamada, T., Watanabe, K., Katsumi, K., Hiyama, A., Watanabe, M., Nakagawa, Y., Okada, M., Endo, T., Shiraishi, Y., Takeuchi, K., Matsunaga, S., Maruo, K., Sakai, K., Kobayashi, S., Ohba, T., Wada, K., Ohya, J., Mori, K. および6人, Tsushima, M., Nishimura, H., Tsuji, T., Okawa, A., Matsumoto, M. & Watanabe, K., 07-2019, : : Journal of Orthopaedic Science. 24, 4, p. 601-606 6 p.

研究成果: Article

Diffuse Idiopathic Skeletal Hyperostosis
Spinal Fractures
Wounds and Injuries
Ossification of Posterior Longitudinal Ligament
Delayed Diagnosis

Standard cardiac rehabilitation program for heart failure

Izawa, H., Yoshida, T., Ikegame, T., Izawa, K. P., Ito, Y., Okamura, H., Osada, N., Kinugawa, S., Kubozono, T., Kono, Y., Kobayashi, K., Nishigaki, K., Higo, T., Hirashiki, A., Miyazawa, Y., Morio, Y., Yanase, M., Yamada, S., Ikeda, H., Momomura, S. I. および4人, Kihara, Y., Yamamoto, K., Goto, Y. & Makita, S., 01-01-2019, : : Circulation Journal. 83, 12, p. 2394-2398 5 p.

研究成果: Article

公開
1 引用 (Scopus)

Stride length of elderly patients with lumbar spinal stenosis: Multi-center study using the Two-Step test

Fujita, N., Sakurai, A., Miyamoto, A., Michikawa, T., Otaka, Y., Suzuki, S., Tsuji, O., Nagoshi, N., Okada, E., Yagi, M., Tsuji, T., Kono, H., Ishii, K., Nakamura, M., Matsumoto, M. & Watanabe, K., 09-2019, : : Journal of Orthopaedic Science. 24, 5, p. 787-792 6 p.

研究成果: Article

Spinal Stenosis
Exercise Test
Logistic Models
Back Pain
Posture
Thymectomy
Blood Vessels

Suppression of heat generation in magnetic stimulation coil applied for treating dysphagia

Mori, H., Kagaya, H., Izumi, S., Yashima, K. & Takagi, T., 01-01-2019, : : Journal of the Magnetics Society of Japan. 43, 4, p. 84-90 7 p.

研究成果: Article

公開
heat generation
Heat generation
stimulation
coils
conductors

Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection

Hayashi, T., Sakakura, N., Ishimura, D., Kozawa, E., Yoshida, M., Sakao, Y., Yamada, H. & Tsukushi, S., 01-03-2019, : : Oncology Letters. 17, 3, p. 3446-3456 11 p.

研究成果: Article

公開
Thoracic Wall
Lung
Neoplasms
Respiratory Function Tests
Vital Capacity

Surgical risk stratification based on preoperative risk factors in adult spinal deformity

Yagi, M., Hosogane, N., Fujita, N., Okada, E., Suzuki, S., Tsuji, O., Nagoshi, N., Asazuma, T., Tsuji, T., Nakamura, M., Matsumoto, M. & Watanabe, K., 01-05-2019, : : Spine Journal. 19, 5, p. 816-826 11 p.

研究成果: Article

Demography
Odds Ratio
ROC Curve
Calibration
Quality of Life

Susceptibility-Weighted Imaging of Deep Venous Congestion in Petroclival Meningioma

Adachi, K., Hasegawa, M., Hayakawa, M., Tateyama, S. & Hirose, Y., 01-02-2019, : : World Neurosurgery. 122, p. e20-e31

研究成果: Article

Hyperemia
Meningioma
Cerebral Veins
Nervous System
Brain Stem

Suvorexant for insomnia in patients with psychiatric disorder: A 1-week, open-label study

Kishi, T., Sakuma, K., Okuya, M., Ninomiya, K., Oya, K., Kubo, M., Matsui, Y., Nomura, I., Okuyama, Y., Matsunaga, S. & Iwata, N., 01-09-2019, : : Neuropsychopharmacology reports. 39, 3, p. 252-255 4 p.

研究成果: Article

公開
Sleep Initiation and Maintenance Disorders
Psychiatry
Sleep
Safety
Major Depressive Disorder

TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets

Araki, K., Araki, A., Honda, D., Izumoto, T., Hashizume, A., Hijikata, Y., Yamada, S., Iguchi, Y., Hara, A., Ikumi, K., Kawai, K., Ishigaki, S., Nakamichi, Y., Tsunekawa, S., Seino, Y., Yamamoto, A., Takayama, Y., Hidaka, S., Tominaga, M., Ohara-Imaizumi, M. および8人, Suzuki, A., Ishiguro, H., Enomoto, A., Yoshida, M., Arima, H., Muramatsu, S. I., Sobue, G. & Katsuno, M., 03-09-2019, : : Journal of Clinical Investigation. 129, 9, p. 3578-3593 16 p.

研究成果: Article

公開
Exocytosis
DNA-Binding Proteins
Amyotrophic Lateral Sclerosis
Insulin
Glucose Intolerance

Ten-year Longitudinal Follow-up MRI Study of Age-related Changes in Thoracic Intervertebral Discs in Asymptomatic Subjects

Okada, E., Daimon, K., Fujiwara, H., Nishiwaki, Y., Nojiri, K., Watanabe, M., Katoh, H., Ishihama, H., Fujita, N., Tsuji, T., Nakamura, M., Matsumoto, M. & Watanabe, K., 15-11-2019, : : Spine. 44, 22, p. E1317-E1324

研究成果: Article

Intervertebral Disc
Spine
Thorax
Magnetic Resonance Imaging
Intervertebral Disc Degeneration