医学部

研究成果 1975 2020

2003
115 引用 (Scopus)

Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production

Topp, M. S., Riddell, S. R., Akatsuka, Y., Jensen, M. C., Blattman, J. N. & Greenberg, P. D., 15-09-2003, : : Journal of Experimental Medicine. 198, 6, p. 947-955 9 p.

研究成果: Article

Interleukin-2
T-Lymphocytes
Antigens
Aptitude
Virus Diseases
46 引用 (Scopus)

Serum carotenoids and mortality from lung cancer: A case-control study nested in the Japan Collaborative Cohort (JACC) Study

Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., Ohno, Y., Mori, M., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Hashimoto, S., Inaba, Y., Hoshiyama, Y. および27人, Suzuki, H., Shimizu, H., Toyoshima, H., Tokudome, S., Kikuchi, S., Koizumi, A., Kawamura, T., Miki, T., Date, C., Sakata, K., Nose, T., Hayakawa, N., Yoshimura, T., Fukuda, K., Okamoto, N., Shio, H., Kitagawa, T., Kuroki, T., Tajima, K., Nakachi, K., Shimamoto, T., Tanaka, H., Hisamichi, S., Nakao, M., Suzuki, T., Hashimoto, T. & Ishibashi, T., 01-01-2003, : : Cancer science. 94, 1, p. 57-63 7 p.

研究成果: Review article

Carotenoids
Case-Control Studies
Lung Neoplasms
Japan
Cohort Studies
26 引用 (Scopus)
Herpesviridae
Herpesviridae Infections
Cytotoxic T-Lymphocytes
Virus Diseases
Viruses
27 引用 (Scopus)

Smoking and colorectal cancer in a non-western population: A prospective cohort study in Japan

Wakai, K., Hayakawa, N., Kojima, M., Tamakoshi, K., Watanabe, Y., Suzuki, K., Hashimoto, S., Tokudome, S., Toyoshima, H., Ito, Y. & Tamakoshi, A., 01-11-2003, : : Journal of Epidemiology. 13, 6, p. 323-331 9 p.

研究成果: Article

Colorectal Neoplasms
Japan
Cohort Studies
Smoking
Colonic Neoplasms
42 引用 (Scopus)

Some anti-chronic inflammatory compounds are DNA polymerase λ-specific inhibitors

Mizushina, Y., Hirota, M., Murakami, C., Ishidoh, T., Kamisuki, S., Shimazaki, N., Takemura, M., Perpelescu, M., Suzuki, M., Yoshida, H., Sugawara, F., Koiwai, O. & Sakaguchi, K., 15-11-2003, : : Biochemical Pharmacology. 66, 10, p. 1935-1944 10 p.

研究成果: Article

Nucleic Acid Synthesis Inhibitors
DNA-Directed DNA Polymerase
Curcumin
Anti-Inflammatory Agents
Tetradecanoylphorbol Acetate
7 引用 (Scopus)

Spatial distributions of A3558 in the core region of the Shapley supercluster

Akimoto, F., Kondou, K., Furuzawa, A., Tawara, Y. & Yamashita, K., 10-10-2003, : : Astrophysical Journal. 596, 1 I, p. 170-180 11 p.

研究成果: Article

spatial distribution
metal
temperature
gas
contraction
13 引用 (Scopus)

Spread of varicella-zoster virus DNA to the environment from varicella patients who were treated with oral acyclovir

Suzuki, K., Yoshikawa, T., Ihira, M., Ohashi, M., Suga, S. & Asano, Y., 01-08-2003, : : Pediatrics International. 45, 4, p. 458-460 3 p.

研究成果: Article

Human Herpesvirus 3
Acyclovir
Chickenpox
Air Filters
Pharynx
7 引用 (Scopus)

Stimulatory effect of prostaglandin F on Na-dependent phosphate transport in osteoblast-like cells

Sato, I., Suzuki, A., Kakita, A., Ono, Y., Miura, Y., Itoh, M. & Oiso, Y., 01-05-2003, : : Prostaglandins Leukotrienes and Essential Fatty Acids. 68, 5, p. 311-315 5 p.

研究成果: Article

Osteoblasts
Prostaglandins F
Phosphates
Protein Kinase C
MAP Kinase Kinase Kinases
38 引用 (Scopus)

Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in golgi apparatus targeting

Nozawa, N., Daikoku, T., Koshizuka, T., Yamauchi, Y., Yoshikawa, T. & Nishiyama, Y., 01-03-2003, : : Journal of Virology. 77, 5, p. 3204-3216 13 p.

研究成果: Article

Lipoylation
Human herpesvirus 1
Human Herpesvirus 1
Golgi Apparatus
Golgi apparatus
105 引用 (Scopus)

Systemic cytokine responses in patients with influenza-associated encephalopathy

Kawada, J. I., Kimura, H., Ito, Y., Hara, S., Iriyama, M., Yoshikawa, T. & Morishima, T., 01-09-2003, : : Journal of Infectious Diseases. 188, 5, p. 690-698 9 p.

研究成果: Article

Brain Diseases
Human Influenza
Cytokines
Nervous System
Febrile Seizures
51 引用 (Scopus)

Testosterone up-regulates aquaporin-4 expression in cultured astrocytes

Gu, F., Hata, R., Toku, K., Yang, L., Ma, Y. J., Maeda, N., Sakanaka, M. & Tanaka, J., 15-06-2003, : : Journal of Neuroscience Research. 72, 6, p. 709-715 7 p.

研究成果: Article

Aquaporin 4
Astrocytes
Testosterone
Up-Regulation
Brain Edema
59 引用 (Scopus)

Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells

Kuzushima, K., Hayashi, N., Kudoh, A., Akatsuka, Y., Tsujimura, K., Morishima, Y. & Tsurumi, T., 15-02-2003, : : Blood. 101, 4, p. 1460-1468 9 p.

研究成果: Article

HLA-A Antigens
T-cells
Human Herpesvirus 4
Viruses
Epitopes
25 引用 (Scopus)
Aichi virus
Kobuvirus
Picornaviridae
Viral RNA
Genome
89 引用 (Scopus)

The accuracy of long-term recall of past body weight in Japanese adult men

Tamakoshi, K., Yatsuya, H., Kondo, T., Hirano, T., Hori, Y., Yoshida, T. & Toyoshima, H., 01-02-2003, : : International Journal of Obesity. 27, 2, p. 247-252 6 p.

研究成果: Article

Body Weight
Weights and Measures
Weight Gain
Weight Loss
Body Mass Index
7 引用 (Scopus)

The Expression of cytokeratin in hepatic stellate cells of the cod

Senda, T. & Nomura, R., 01-12-2003, : : Archives of Histology and Cytology. 66, 5, p. 437-444 8 p.

研究成果: Article

Gadiformes
Hepatic Stellate Cells
Keratins
Cytoskeleton
Desmin
7 引用 (Scopus)

The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase α is important in discriminating correct deoxyribonucleotides from incorrect ones

Limsirichaikul, S., Ogawa, M., Niimi, A., Iwai, S., Murate, T., Yoshida, S. & Suzuki, M., 23-05-2003, : : Journal of Biological Chemistry. 278, 21, p. 19079-19086 8 p.

研究成果: Article

Deoxyribonucleotides
DNA-Directed DNA Polymerase
Yeast
Saccharomyces cerevisiae
Nucleotides
188 引用 (Scopus)

The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state

Tamakoshi, K., Yatsuya, H., Kondo, T., Hori, Y., Ishikawa, M., Zhang, H., Murata, C., Otsuka, R., Zhu, S. & Toyoshima, H., 01-04-2003, : : International Journal of Obesity. 27, 4, p. 443-449 7 p.

研究成果: Article

C-reactive protein
metabolic syndrome
C-Reactive Protein
Reference Values
Blood Pressure
51 引用 (Scopus)

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids

Liu, M. C., Maruyama, S., Mizuno, M., Morita, Y., Hanaki, S., Yuzawa, Y. & Matsuo, S., 01-09-2003, : : Clinical and Experimental Nephrology. 7, 3, p. 186-194 9 p.

研究成果: Article

Aristolochic Acids
Aristolochia
Kidney
Urine
Azotemia
119 引用 (Scopus)

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D. A., Berger, M. S. & Pieper, R. O., 01-11-2003, : : Molecular and Cellular Biology. 23, 22, p. 8306-8315 10 p.

研究成果: Article

DNA Mismatch Repair
p38 Mitogen-Activated Protein Kinases
DNA
temozolomide
cdc25 Phosphatases
8 引用 (Scopus)

The Vpu protein of human immunodeficiency virus type 1 plays a protective role against virus-induced apoptosis in primary CD4+ T lymphocytes

Komoto, S., Tsuji, S., Ibrahim, M. S., Li, Y. G., Warachit, J., Taniguchi, K. & Ikuta, K., 01-10-2003, : : Journal of Virology. 77, 19, p. 10304-10313 10 p.

研究成果: Article

Human immunodeficiency virus 1
HIV-1
apoptosis
T-lymphocytes
Apoptosis
122 引用 (Scopus)

Three tests for predicting aspiration without videofluorography

Tohara, H., Saitoh, E., Mays, K. A., Kuhlemeier, K. & Palmer, J. B., 01-03-2003, : : Dysphagia. 18, 2, p. 126-134 9 p.

研究成果: Article

Deglutition
Deglutition Disorders
Tongue
Water
X-Rays
9 引用 (Scopus)

Thymus leukemia antigen (TL)-specific cytotoxic T lymphocytes recognized the α1/α2 domain of TL free from antigenic peptides

Tsujimura, K., Obata, Y., Kondo, E., Nishida, K., Matsudaira, Y., Akatsuka, Y., Kuzushima, K. & Takahashi, T., 01-11-2003, : : International Immunology. 15, 11, p. 1319-1326 8 p.

研究成果: Article

Cytotoxic T-Lymphocytes
Peptides
thymus-leukemia antigens
T-Lymphocyte Epitopes
Recombinant Proteins
138 引用 (Scopus)

Total sleep deprivation elevates blood pressure through arterial baroreflex resetting: A study with microneurographic technique

Ogawa, Y., Kanbayashi, T., Saito, Y., Takahashi, Y., Kitajima, T., Takahashi, K., Hishikawa, Y. & Shimizu, T., 15-12-2003, : : Sleep. 26, 8, p. 986-989 4 p.

研究成果: Article

Sleep Deprivation
Baroreflex
Arterial Pressure
Blood Pressure
Muscles
99 引用 (Scopus)

Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: Comparison with rapid troponin T and myoglobin tests

Seino, Y., Ogata, K. I., Takano, T., Ishii, J. I., Hishida, H., Morita, H., Takeshita, H., Takagi, Y., Sugiyama, H., Tanaka, T. & Kitaura, Y., 15-08-2003, : : American Journal of Medicine. 115, 3, p. 185-190 6 p.

研究成果: Article

Fatty Acid-Binding Proteins
Troponin T
Myoglobin
Acute Pain
Chest Pain
3 引用 (Scopus)

U-shaped association between white blood cell count and fasting plasma glucose level [1]

Tamakoshi, K., Yatsuya, H., Kondo, T., Hori, Y., Zhang, H., Ishikawa, M., Murata, C., Otsuka, R., Zhu, S. K. & Toyoshima, H., 01-03-2003, : : Diabetes care. 26, 3, 1 p.

研究成果: Letter

Leukocyte Count
Blood Glucose
Fasting
Diabetes Mellitus
Glucose
13 引用 (Scopus)

Utility of the dried blood on filter paper as a source of cytokine mRNA for the analysis of immunoreactions in Plasmodium yoelii infection

Maeno, Y., Nakazawa, S., Nagashima, S., Sasaki, J., Higo, K. M. & Taniguchi, K., 01-07-2003, : : Acta Tropica. 87, 2, p. 295-300 6 p.

研究成果: Article

Plasmodium yoelii
messenger RNA
Malaria
cytokines
Cytokines
8 引用 (Scopus)

Validation of endoscopic 13C-urea breath test with nondispersive infrared spectrometric analysis in the management of Helicobacter pylori infection

Isomoto, H., Inoue, K. I., Mizuta, Y., Nakazato, M., Kanazawa, Y., Nishiyama, H., Ohara, H., Urata, M., Omagari, K., Miyazaki, M., Murase, K., Murata, I. & Kohno, S., 01-03-2003, : : Hepato-gastroenterology. 50, 50, p. 422-425 4 p.

研究成果: Article

Breath Tests
Helicobacter Infections
Helicobacter pylori
Urea
Isotopes
12 引用 (Scopus)

Variation of Human Herpesvirus 7 Shedding in Saliva

Ihira, M., Yoshikawa, T., Ohashi, M., Enomono, Y., Akimoto, S., Suga, S., Saji, H., Nishiyama, Y. & Asano, Y., 01-11-2003, : : Journal of Infectious Diseases. 188, 9, p. 1352-1354 3 p.

研究成果: Article

Human Herpesvirus 7
Saliva
Virus Shedding
Antibodies
Viral Load

Varicella-zoster virus

Yoshikawa, T. & Nishiyama, Y., 03-2003, : : Nippon rinsho. Japanese journal of clinical medicine. 61 Suppl 3, p. 575-581 7 p.

研究成果: Review article

Molecular Diagnostic Techniques
Chickenpox Vaccine
Attenuated Vaccines
Human Herpesvirus 3
Viral Genes
20 引用 (Scopus)
Mechanical Stress
Inositol 1,4,5-Trisphosphate
Cell adhesion
Cell Adhesion
Integrins
2002
12 引用 (Scopus)

Ability to induce p53 and caspase-mediated apoptosis in primary CD4+ T cells is variable among primary isolates of human immunodeficiency virus type 1

Komoto, S., Kinomoto, M., Horikoshi, H., Shiraga, M., Kurosu, T., Mukai, T., Auwanit, W., Otake, T., Oishi, I. & Ikuta, K., 01-01-2002, : : AIDS Research and Human Retroviruses. 18, 6, p. 435-446 12 p.

研究成果: Article

Caspases
HIV-1
Apoptosis
T-Lymphocytes
Blood Cells

A case of anaphylaxis from cefatrizine propylene glycolate (Cefrachol® dry syrup)

Washimi, Y., Nagashima, C., Sowa, J., Yagami, A., Tsuruta, K., Akamatsu, H., Matsunaga, K. & Ohashi, M., 01-06-2002, : : Skin Research. 1, 3, p. 172-175 4 p.

研究成果: Article

glycolic acid
Cefatrizine
Anaphylaxis
Ambroxol
Chlorpheniramine
6 引用 (Scopus)

A case of fulminant type 1 diabetes with graves' disease.

Miura, Y., Suzuki, A., Sato, I., Kato, Y. & Oiso, Y., 10-2002, : : Diabetes care. 25, 10, p. 1894-1895 2 p.

研究成果: Letter

Pregnancy in Diabetics
Ketone Bodies
C-Peptide
Graves Disease
Amylases

A case of occupational contact dermatitis from epoxy-resins

Tomitaka, A., Akamatsu, H., Sowa, J., Matsunaga, K. & Suzuki, K., 01-01-2002, : : Nishinihon Journal of Dermatology. 64, 6, p. 684-687 4 p.

研究成果: Article

Occupational Dermatitis
Epoxy Resins
Patch Tests
Contact Dermatitis
Anti-Allergic Agents
19 引用 (Scopus)

Anaphylaxis after hamster bites: A rare case?

Tomitaka, A., Suzuki, K., Akamatsu, H. & Matsunaga, K., 15-04-2002, : : Contact Dermatitis. 46, 2, 1 p.

研究成果: Article

Pets
Domestic Animals
Laboratory Animals
Anaphylaxis
Bites and Stings
17 引用 (Scopus)

Anaphylaxis to human seminal plasma

Tomitaka, A., Suzuki, K., Akamatsu, H. & Matsunaga, K., 01-11-2002, : : Allergy: European Journal of Allergy and Clinical Immunology. 57, 11, p. 1081-1082 2 p.

研究成果: Article

Radioallergosorbent Test
Antibody Specificity
Urticaria
Anaphylaxis
Skin Tests
7 引用 (Scopus)

An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates

Kai, T., Matsunaga, R., Eguchi, M., Kamiya, H., Kasai, H., Suzuki, M. & Izuta, S., 15-01-2002, : : Nucleic Acids Research. 30, 2, p. 569-573 5 p.

研究成果: Article

Xenopus
DNA Replication
Protein Kinases
Ovum
Nucleotides
22 引用 (Scopus)

Anti-apoptotic protein kinase of herpes simplex virus

Nishiyama, Y. & Murata, T., 01-03-2002, : : Trends in Microbiology. 10, 3, p. 105-107 3 p.

研究成果: Review article

Apoptosis Regulatory Proteins
Simplexvirus
Protein Kinases
Apoptosis
Viral Genes
19 引用 (Scopus)

Antiproliferative activity induced by the somatostatin analogue, TT-232, in human pancreatic cancer cells

Lee, J. U., Hosotani, R., Wada, M., Doi, R., Koshiba, T., Fujimoto, K., Miyamoto, Y., Tsuji, S., Nakajima, S., Hirohashi, M., Uehara, T., Arano, Y., Fujii, N. & Imamura, M., 22-07-2002, : : European Journal of Cancer. 38, 11, p. 1526-1534 9 p.

研究成果: Article

Somatostatin
Pancreatic Neoplasms
Protein Tyrosine Phosphatases
Growth
Binding Sites
60 引用 (Scopus)

A prospective study of stomach cancer death in relation to green tea consumption in Japan

the Japan Collaborative Cohort Study Group, 01-01-2002, : : British Journal of Cancer. 87, 3, p. 309-313 5 p.

研究成果: Article

Tea
Stomach Neoplasms
Japan
Prospective Studies
Drinking
91 引用 (Scopus)

Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines

Nakagawa, Y., Akao, Y., Morikawa, H., Hirata, I., Katsu, K., Naoe, T., Ohishi, N. & Yagi, K., 29-03-2002, : : Life Sciences. 70, 19, p. 2253-2269 17 p.

研究成果: Article

Oxidative stress
Colonic Neoplasms
Oxidative Stress
Cells
Apoptosis
38 引用 (Scopus)

A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis

Nishikawa, T., Maemura, K., Hirata, I., Matsuse, R., Morikawa, H., Toshina, K., Murano, M., Hashimoto, K., Nakagawa, Y., Saitoh, O., Uchida, K. & Katsu, K., 14-03-2002, : : Clinica Chimica Acta. 318, 1-2, p. 107-112 6 p.

研究成果: Article

Polymerase chain reaction
Polymorphism
Early Detection of Cancer
Point Mutation
Restriction Fragment Length Polymorphisms
42 引用 (Scopus)

Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response

Mutimer, H. P., Akatsuka, Y., Manley, T., Chuang, E. L., Boeckh, M., Harrington, R., Jones, T. & Riddell, S. R., 01-09-2002, : : Journal of Infectious Diseases. 186, 5, p. 701-705 5 p.

研究成果: Article

Uveitis
Cytomegalovirus
T-Lymphocytes
T-Cell Antigen Receptor Specificity
Immediate-Early Proteins
95 引用 (Scopus)

AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats

Nagata, K., Somura, F., Obata, K., Odashima, M., Izawa, H., Ichihara, S., Nagasaka, T., Iwase, M., Yamada, Y., Nakashima, N. & Yokota, M., 14-08-2002, : : Hypertension. 40, 2, p. 168-174 7 p.

研究成果: Article

Inbred Dahl Rats
Angiotensin Type 1 Receptor
Calcineurin
Cardiomegaly
Tacrolimus
121 引用 (Scopus)

Aurora-B associated protein phosphatases as negative regulators of kinase activation

Sugiyama, K., Sugiura, K., Hara, T., Sugimoto, K., Shima, H., Honda, K., Furukawa, K., Yamashita, S. & Urano, T., 01-01-2002, : : Oncogene. 21, 20, p. 3103-3111 9 p.

研究成果: Article

Phosphoprotein Phosphatases
Phosphotransferases
Histones
Arginine Kinase
Protamine Kinase

Autonomic nervous system examinations

Watanabe, E. & Kodama, I., 07-2002, : : Nippon rinsho. Japanese journal of clinical medicine. 60, 7, p. 1299-1307 9 p.

研究成果: Review article

Baroreflex
Autonomic Nervous System
Arterial Pressure
Electrocardiography
Heart Rate
140 引用 (Scopus)

Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Matsuo, A., Lin, J. X., Ihara, M. & McGeer, P. L., 04-01-2002, : : Brain Research. 924, 1, p. 63-70 8 p.

研究成果: Article

Demyelinating Diseases
Chromogranin A
Protein Precursors
Internal Capsule
Peptides
13 引用 (Scopus)

Bisphenol A inhibits Cl- secretion by inhibition of basolateral K+ conductance in human airway epithelial cells

Ito, Y., Sato, S., Son, M., Kondo, M., Kume, H., Takagi, K. & Yamaki, K., 04-07-2002, : : Journal of Pharmacology and Experimental Therapeutics. 302, 1, p. 80-87 8 p.

研究成果: Article

Epithelial Cells
Isoproterenol
Charybdotoxin
8-Bromo Cyclic Adenosine Monophosphate
Tamoxifen
97 引用 (Scopus)

Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion

Ueno, M., Tomimoto, H., Akiguchi, I., Wakita, H. & Sakamoto, H., 01-01-2002, : : Journal of Cerebral Blood Flow and Metabolism. 22, 1, p. 97-104 8 p.

研究成果: Article

Horseradish Peroxidase
Blood-Brain Barrier
Cytoplasm
Endothelial Cells
Corpus Callosum
7 引用 (Scopus)

cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Ohtsuki, M., Shiraishi, H., Kato, T., Kuroda, R., Tazawa, M., Sumi-Ichinose, C., Tada, S., Udagawa, Y., Itoh, M., Hishida, H., Ichinose, H., Nagatsu, T., Hagino, Y. & Nomura, T., 22-03-2002, : : Life Sciences. 70, 18, p. 2187-2198 12 p.

研究成果: Article

Biosynthesis
Endothelial cells
Human Umbilical Vein Endothelial Cells
GTP Cyclohydrolase
Cytokines