Hirohiko Akamatsu

2022

Age-related decrease in responsiveness of CD271-positive skin stem cells to growth factors

Akamatsu, H., Yamada, T., Sanada, A., Ishii, Y., Iwata, Y., Arima, M., Hasegawa, S. & Sugiura, K., 08-2022, In: Experimental dermatology. 31, 8, p. 1264-1269 6 p.

研究成果: Article › 査読

Enhanced Type I Collagen Synthesis in Fibroblasts by Dermal Stem/Progenitor Cell-Derived Exosomes

Sanada, A., Yamada, T., Hasegawa, S., Ishii, Y., Hasebe, Y., Iwata, Y., Arima, M., Sugiura, K. & Akamatsu, H., 07-2022, In: Biological and Pharmaceutical Bulletin. 45, 7, p. 872-880 9 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Increase in inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging

Kawagishi-Hotta, M., Hasegawa, S., Hasebe, Y., Inoue, Y., Okuno, R., Arima, M., Iwata, Y., Sugiura, K. & Akamatsu, H., 06-2022, In: Journal of Dermatological Science. 106, 3, p. 150-158 9 p.

研究成果: Article › 査読

Melanin accumulation in dermal stem cells deteriorates their exosome-mediated skin basement membrane construction in solar lentigo

Miyachi, K., Yamada, T., Sanada, A., Inoue, Y., Hasebe, Y., Arima, M., Iwata, Y., Hasegawa, S., Sugiura, K. & Akamatsu, H., 12-2022, In: Experimental dermatology. 31, 12, p. 1881-1890 10 p.

研究成果: Article › 査読

Terminal differentiation of keratinocytes was damaged in type 2 diabetic mice

Takayanagi, T., Hirai, H., Asada, Y., Yamada, T., Hasegawa, S., Tomatsu, E., Maeda, Y., Yoshino, Y., Hiratsuka, I., Sekiguchi-Ueda, S., Shibata, M., Seino, Y., Sugimura, Y., Akamatsu, H., Itoh, M. & Suzuki, A., 07-2022, In: Molecular Biology Reports. 49, 7, p. 5875-5882 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

UVA causes dysfunction of ETBR and BMPR2 in vascular endothelial cells, resulting in structural abnormalities of the skin capillaries

Miyachi, K., Murakami, Y., Inoue, Y., Yoshioka, H., Hirose, O., Yamada, T., Hasegawa, S., Arima, M., Iwata, Y., Sugiura, K. & Akamatsu, H., 02-2022, In: Journal of Dermatological Science. 105, 2, p. 121-129 9 p.

研究成果: Article › 査読

2021

Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor

Inoue, Y., Hasegawa, S., Hasebe, Y., Kawagishi-Hotta, M., Okuno, R., Yamada, T., Adachi, H., Miyachi, K., Ishii, Y., Sugiura, K. & Akamatsu, H., 10-2021, In: Biological and Pharmaceutical Bulletin. 44, 10, p. 1403-1412 10 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin

Kawagishi-Hotta, M., Hasegawa, S., Inoue, Y., Hasebe, Y., Arima, M., Iwata, Y., Sugiura, K. & Akamatsu, H., 12-2021, In: Regenerative Therapy. 18, p. 191-201 11 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

SASP-induced macrophage dysfunction may contribute to accelerated senescent fibroblast accumulation in the dermis

Ogata, Y., Yamada, T., Hasegawa, S., Sanada, A., Iwata, Y., Arima, M., Nakata, S., Sugiura, K. & Akamatsu, H., 01-2021, In: Experimental dermatology. 30, 1, p. 84-91 8 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Senescent cell removal via JAG1-NOTCH1 signalling in the epidermis

Yoshioka, H., Yamada, T., Hasegawa, S., Miyachi, K., Ishii, Y., Hasebe, Y., Inoue, Y., Tanaka, H., Iwata, Y., Arima, M., Sugiura, K. & Akamatsu, H., 09-2021, In: Experimental dermatology. 30, 9, p. 1268-1278 11 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2020

Gremlin 2 increased in the skin with age as a senescence-associated secretory phenotype factor

Kawagishi-Hotta, M., Hasegawa, S., Hasebe, Y., Sugiura, K. & Akamatsu, H., 12-2020, In: Journal of Dermatology. 47, 12, p. 1457-1458 2 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

2019

CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration

Yamada, T., Hasegawa, S., Hasebe, Y., Kawagishi-Hotta, M., Arima, M., Iwata, Y., Kobayashi, T., Numata, S., Yamamoto, N., Nakata, S., Sugiura, K. & Akamatsu, H., 22-01-2019, In: Archives of Dermatological Research. 311, 1, p. 55-62 8 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis

Kawagishi-Hotta, M., Hasegawa, S., Igarashi, T., Date, Y., Ishii, Y., Inoue, Y., Hasebe, Y., Yamada, T., Arima, M., Iwata, Y., Kobayashi, T., Nakata, S., Sugiura, K. & Akamatsu, H., 12-2019, In: Regenerative Therapy. 11, p. 324-330 7 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

UV irradiation-induced DNA hypomethylation around WNT1 gene: Implications for solar lentigines

Yamada, T., Hasegawa, S., Iwata, Y., Arima, M., Kobayashi, T., Numata, S., Nakata, S., Sugiura, K. & Akamatsu, H., 06-2019, In: Experimental dermatology. 28, 6, p. 723-729 7 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

2018

Extracellular proteoglycan decorin maintains human hair follicle stem cells

Miyachi, K., Yamada, T., Kawagishi-Hotta, M., Hasebe, Y., Date, Y., Hasegawa, S., Arima, M., Iwata, Y., Kobayashi, T., Numata, S., Yamamoto, N., Nakata, S., Sugiura, K. & Akamatsu, H., 12-2018, In: Journal of Dermatology. 45, 12, p. 1403-1410 8 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017

Hayashi, N., Akamatsu, H., Iwatsuki, K., Shimada-Omori, R., Kaminaka, C., Kurokawa, I., Kono, T., Kobayashi, M., Tanioka, M., Furukawa, F., Furumura, M., Yamasaki, O., Yamasaki, K., Yamamoto, Y., Miyachi, Y. & Kawashima, M., 08-2018, In: Journal of Dermatology. 45, 8, p. 898-935 38 p.

研究成果: Article › 査読

Open Access

32 被引用数 (Scopus)

Laminin-332 regulates differentiation of human interfollicular epidermal stem cells

Yamada, T., Hasegawa, S., Miyachi, K., Date, Y., Inoue, Y., Yagami, A., Arima, M., Iwata, Y., Yamamoto, N., Nakata, S., Matsunaga, K., Sugiura, K. & Akamatsu, H., 04-2018, In: Mechanisms of Ageing and Development. 171, p. 37-46 10 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

2017

Dermal CD271⁺ cells are closely associated with regeneration of the dermis in the wound healing process

Iwata, Y., Hasebe, Y., Hasegawa, S., Nakata, S., Yagami, A., Matsunaga, K., Sugiura, K. & Akamatsu, H., 2017, In: Acta Dermato-Venereologica. 97, 5, p. 593-600 8 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Enhancement of individual differences in proliferation and differentiation potentials of aged human adipose-derived stem cells

Kawagishi-Hotta, M., Hasegawa, S., Igarashi, T., Yamada, T., Takahashi, M., Numata, S., Kobayashi, T., Iwata, Y., Arima, M., Yamamoto, N., Yagami, A., Nakata, S., Uzawa, T., Matsunaga, K., Sugiura, K. & Akamatsu, H., 01-06-2017, In: Regenerative Therapy. 6, p. 29-40 12 p.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

Skin-resident stem cells and wound healing

Iwata, Y., Akamatsu, H., Hasebe, Y., Hasegawa, S. & Sugiura, K., 2017, In: Japanese Journal of Clinical Immunology. 40, 1, p. 1-11 11 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication

Kawashima, M., Sato, S., Furukawa, F., Matsunaga, K., Akamatsu, H., Igarashi, A., Tsunemi, Y., Hayashi, N., Yamamoto, Y., Nagare, T. & Katsuramaki, T., 07-2017, In: Journal of Dermatology. 44, 7, p. 774-782 9 p.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

2016

Age-related decrease in CD271⁺ cells in human skin

Akamatsu, H., Hasegawa, S., Yamada, T., Mizutani, H., Nakata, S., Yagami, A. & Matsunaga, K., 01-03-2016, In: Journal of Dermatology. 43, 3, p. 311-313 3 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Microorganisms inhabiting follicular contents of facial acne are not only Propionibacterium but also Malassezia spp.

Akaza, N., Akamatsu, H., Numata, S., Yamada, S., Yagami, A., Nakata, S. & Matsunaga, K., 01-08-2016, In: Journal of Dermatology. 43, 8, p. 906-911 6 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

2015

Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis

Ohgo, S., Hasegawa, S., Hasebe, Y., Mizutani, H., Nakata, S. & Akamatsu, H., 01-07-2015, In: Experimental dermatology. 24, 7, p. 552-554 3 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

2014

Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae

Yamada, T., Hasegawa, S., Inoue, Y., Date, Y., Arima, M., Yagami, A., Iwata, Y., Takahashi, M., Yamamoto, N., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 01-09-2014, In: Experimental dermatology. 23, 9, p. 652-658 7 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Analysis of facial skin-resident microbiota in Japanese acne patients

Numata, S., Akamatsu, H., Akaza, N., Yagami, A., Nakata, S. & Matsunaga, K., 02-2014, In: Dermatology. 228, 1, p. 86-92 7 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Comprehensive analysis of melanogenesis and proliferation potential of melanocyte lineage in solar lentigines

Yamada, T., Hasegawa, S., Inoue, Y., Date, Y., Arima, M., Yagami, A., Iwata, Y., Abe, M., Takahashi, M., Yamamoto, N., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 03-2014, In: Journal of Dermatological Science. 73, 3, p. 251-257 7 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris

Akaza, N., Akamatsu, H., Numata, S., Matsusue, M., Mashima, Y., Miyawaki, M., Yamada, S., Yagami, A., Nakata, S. & Matsunaga, K., 01-12-2014, In: Journal of Dermatology. 41, 12, p. 1069-1076 8 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Histologic study of collagen and stem cells after radiofrequency treatment for aging skin

Yokoyama, Y., Akita, H., Hasegawa, S., Negishi, K., Akamatsu, H. & Matsunaga, K., 04-2014, In: Dermatologic Surgery. 40, 4, p. 390-397 8 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

2013

Analysis of the effects of hydroquinone and arbutin on the differentiation of melanocytes

Inoue, Y., Hasegawa, S., Yamada, T., Date, Y., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 11-2013, In: Biological and Pharmaceutical Bulletin. 36, 11, p. 1722-1730 9 p.

研究成果: Article › 査読

Open Access

27 被引用数 (Scopus)

Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-β1

Ohgo, S., Hasegawa, S., Hasebe, Y., Mizutani, H., Nakata, S. & Akamatsu, H., 11-2013, In: Experimental dermatology. 22, 11, p. 769-771 3 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea

Takahashi, M., Akamatsu, H., Yagami, A., Hasegawa, S., Ohgo, S., Abe, M., Iwata, Y., Arima, M., Mizutani, H., Nakata, S. & Matsunaga, K., 09-2013, In: Journal of Dermatology. 40, 9, p. 720-725 6 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Lignin Induces ES Cells to Differentiate into Neuroectodermal Cells through Mediation of the Wnt Signaling Pathway

Inoue, Y., Hasegawa, S., Yamada, T., Date, Y., Mizutani, H., Nakata, S. & Akamatsu, H., 21-06-2013, In: PloS one. 8, 6, e66376.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Major amino acids in collagen hydrolysate regulate the differentiation of mouse embryoid bodies

Date, Y., Hasegawa, S., Yamada, T., Inoue, Y., Mizutani, H., Nakata, S. & Akamatsu, H., 09-2013, In: Journal of Bioscience and Bioengineering. 116, 3, p. 386-390 5 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Optimal patch application time in the evaluation of skin irritation

Kanto, H., Washizaki, K., Ito, M., Matsunaga, K., Akamatsu, H., Kawai, K., Katoh, N., Natsuaki, M., Yoshimura, I., Kojima, H., Okamoto, Y., Okuda, M., Kuwahara, H., Sugiyama, M., Kinoshita, S. & Mori, F., 05-2013, In: Journal of Dermatology. 40, 5, p. 363-369 7 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Protective effect of hochuekkito, a Kampo prescription, against ultraviolet B irradiation-induced skin damage in hairless mice

Yanagihara, S., Kobayashi, H., Tamiya, H., Tsuruta, D., Okano, Y., Takahashi, K., Masaki, H., Yamada, T., Hasegawa, S., Akamatsu, H. & Ishii, M., 03-2013, In: Journal of Dermatology. 40, 3, p. 201-206 6 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers

Iwata, Y., Akamatsu, H., Hasegawa, S., Takahashi, M., Yagami, A., Nakata, S. & Matsunaga, K., 08-2013, In: Journal of Dermatological Science. 71, 2, p. 122-129 8 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

Wnt/β-Catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in uvb-induced epidermal pigmentation

Yamada, T., Hasegawa, S., Inoue, Y., Date, Y., Yamamoto, N., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 12-2013, In: Journal of Investigative Dermatology. 133, 12, p. 2753-2762 10 p.

研究成果: Article › 査読

Open Access

97 被引用数 (Scopus)

2012

Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis

Inoue, Y., Hasegawa, S., Yamada, T., Date, Y., Mizutani, H., Nakata, S., Matsunaga, K. & Akamatsu, H., 05-2012, In: Pigment Cell and Melanoma Research. 25, 3, p. 299-311 13 p.

研究成果: Article › 査読

Open Access

13 被引用数 (Scopus)

Increased hydrophobicity in Malassezia species correlates with increased proinflammatory cytokine expression in human keratinocytes

Akaza, N., Akamatsu, H., Takeoka, S., Mizutani, H., Nakata, S. & Matsunaga, K., 11-2012, In: Medical Mycology. 87, 8, p. 802-810 9 p.

研究成果: Article › 査読

Open Access

24 被引用数 (Scopus)

Malassezia globosa tends to grow actively in summer conditions more than other cutaneous Malassezia species

Akaza, N., Akamatsu, H., Takeoka, S., Sasaki, Y., Mizutani, H., Nakata, S. & Matsunaga, K., 07-2012, In: Journal of Dermatology. 39, 7, p. 613-616 4 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

2011

Acne management in Japan: Study of patient adherence

Miyachi, Y., Hayashi, N., Furukawa, F., Akamatsu, H., Matsunaga, K., Watanabe, S. & Kawashima, M., 11-2011, In: Dermatology. 223, 2, p. 174-181 8 p.

研究成果: Article › 査読

33 被引用数 (Scopus)

Analysis of cell characterization using cell surface markers in the dermis

Hasebe, Y., Hasegawa, S., Hashimoto, N., Toyoda, M., Matsumoto, K., Umezawa, A., Yagami, A., Matsunaga, K., Mizutani, H., Nakata, S. & Akamatsu, H., 05-2011, In: Journal of Dermatological Science. 62, 2, p. 98-106 9 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

2010

Age-related changes of p75 Neurotrophin receptor-positive adipose-derived stem cells

Yamada, T., Akamatsu, H., Hasegawa, S., Yamamoto, N., Yoshimura, T., Hasebe, Y., Inoue, Y., Mizutani, H., Uzawa, T., Matsunaga, K. & Nakata, S., 04-2010, In: Journal of Dermatological Science. 58, 1, p. 36-42 7 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

Cutaneous Malassezia microbiota in atopic dermatitis patients differ by gender and body part

Akaza, N., Akamatsu, H., Sasaki, Y., Takeoka, S., Kishi, M., Mizutani, H., Sano, A., Hirokawa, K., Nakata, S. & Matsunaga, K., 10-2010, In: Dermatology. 221, 3, p. 253-260 8 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Cutaneous Malassezia microbiota of healthy subjects differ by sex, body part and season

Akaza, N., Akamatsu, H., Sasaki, Y., Takeoka, S., Kishi, M., Mizutani, H., Sano, A., Hirokawa, K., Nakata, S. & Matsunaga, K., 09-2010, In: Journal of Dermatology. 37, 9, p. 786-792 7 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

Extensive subcutaneous induration on the back in a patient with subcutaneous panniculitis-like T-cell lymphoma

Kosai, N., Tsuruta, K., Yamakita, T., Matsunaga, K., Akamatsu, H. & Mizoguchi, Y., 2010, In: Nishinihon Journal of Dermatology. 72, 2, p. 106-110 5 p.

研究成果: Article › 査読

Melanocyte stem cells express receptors for canonical Wnt-signaling pathway on their surface

Yamada, T., Akamatsu, H., Hasegawa, S., Inoue, Y., Date, Y., Mizutani, H., Yamamoto, N., Matsunaga, K. & Nakata, S., 11-06-2010, In: Biochemical and Biophysical Research Communications. 396, 4, p. 837-842 6 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

The co-application effects of fullerene and ascorbic acid on UV-B irradiated mouse skin

Ito, S., Itoga, K., Yamato, M., Akamatsu, H. & Okano, T., 12-01-2010, In: Toxicology. 267, 1-3, p. 27-38 12 p.

研究成果: Article › 査読

36 被引用数 (Scopus)

2009

Chronic stress induces mast cell degranulation and increases substance P in the skin of atopic dermatitis mice more than normal mice

Yamakita, T., Shimizu, Y., Arima, M., Matsunaga, K. & Akamatsu, H., 01-12-2009, In: skin research. 8, SUPPL. 12, p. 687-689 3 p.

研究成果: Article › 査読

赤松 浩彦

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赤松浩彦