• 2800 引用
  • 30 h指数
1992 …2020

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

  • 2800 引用
  • 30 h指数
  • 61 Article
  • 2 Comment/debate
  • 2 Letter
  • 1 Review article
2020

Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat

Takahashi, Y., Wakita, H., Mizutani, K., Watanabe, A., Sonoda, S. & Tomimoto, H., 27-01-2020, : : Neuroreport. 31, 2, p. 148-155 8 p.

研究成果: Article

2019

Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice

Shimada, T., Shindo, A., Matsuyama, H., Yata, K., Niwa, A., Sasaki, R., Ayaki, T., Maki, T., Wakita, H. & Tomimoto, H., 21-06-2019, : : Neuroscience Letters. 704, p. 133-140 8 p.

研究成果: Article

2018
2016

Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction

Mizutani, K., Sonoda, S., Wakita, H., Okazaki, H., Katoh, Y., Chihara, T. & Shimpo, K., 15-06-2016, : : NeuroReport. 27, 9, p. 659-664 6 p.

研究成果: Article

4 引用 (Scopus)
2015

Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning

Miyake, S. I., Wakita, H., Bernstock, J. D., Castri, P., Ruetzler, C., Miyake, J., Lee, Y. J. & Hallenbeck, J. M., 01-12-2015, : : Journal of neurochemistry. 135, 5, p. 943-957 15 p.

研究成果: Article

9 引用 (Scopus)
9 引用 (Scopus)
2014

Animal models of vascular dementia: Translational potential at the present time and in 2050

Tomimoto, H. & Wakita, H., 01-01-2014, : : Future Neurology. 9, 2, p. 163-172 10 p.

研究成果: Review article

1 引用 (Scopus)
8 引用 (Scopus)

Stem cells from human exfoliated deciduous teeth enhance recovery from focal cerebral ischemia in rats

Sugiyama, M., Hattori, H., Inoue, T., Wakita, H., Hibi, H. & Ueda, M., 01-10-2014, : : Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 26, 4, p. 443-449 7 p.

研究成果: Article

2 引用 (Scopus)
2013

Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats

Inoue, T., Sugiyama, M., Hattori, H., Wakita, H., Wakabayashi, T. & Ueda, M., 01-01-2013, : : Tissue Engineering - Part A. 19, 1-2, p. 24-29 6 p.

研究成果: Article

70 引用 (Scopus)

Subcortical vascular dementia

Wakita, H., 2013, : : Folia Pharmacologica Japonica. 141, 6, p. 352-353 2 p.

研究成果: Comment/debate

Susceptibility-weighted imaging effectively reveals small cavernomas

Kataoka, S. & Wakita, H., 05-12-2013, : : Internal Medicine. 52, 23, p. 2687-2688 2 p.

研究成果: Comment/debate

2011

Dental pulp-derived CD31-/CD146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats

Sugiyama, M., Iohara, K., Wakita, H., Hattori, H., Ueda, M., Matsushita, K. & Nakashima, M., 01-05-2011, : : Tissue Engineering - Part A. 17, 9-10, p. 1303-1311 9 p.

研究成果: Article

61 引用 (Scopus)

Watershed infarcts in a multiple microembolic model of monkey

Maki, T., Wakita, H., Mase, M., Itagaki, I., Saito, N., Ono, F., Adachi, K., Ito, H., Takahashi, R., Ihara, M. & Tomimoto, H., 20-07-2011, : : Neuroscience Letters. 499, 2, p. 80-83 4 p.

研究成果: Article

8 引用 (Scopus)
2010

E-selectin targeting to visualize tumors in vivo

Hirai, M., Hiramatsu, Y., Iwashita, S., Otani, T., Chen, L., Li, Y. G., Okada, M., Oie, K., Igarashi, K., Wakita, H. & Seno, M., 01-03-2010, : : Contrast Media and Molecular Imaging. 5, 2, p. 70-77 8 p.

研究成果: Article

10 引用 (Scopus)

Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function

Minagawa, H., Watanabe, A., Akatsu, H., Adachi, K., Ohtsuka, C., Terayama, Y., Hosono, T., Takahashi, S., Wakita, H., Jung, C. G., Komano, H. & Michikawa, M., 03-12-2010, : : Journal of Biological Chemistry. 285, 49, p. 38382-38388 7 p.

研究成果: Article

27 引用 (Scopus)
5 引用 (Scopus)
2008

A novel stem cell source for vasculogenesis in ischemia: Subfraction of side population cells from dental pulp

Iohara, K., Zheng, L., Wake, H., Ito, M., Nabekura, J., Wakita, H., Nakamura, H., Into, T., Matsushita, K. & Nakashima, M., 01-09-2008, : : Stem Cells. 26, 9, p. 2408-2418 11 p.

研究成果: Article

167 引用 (Scopus)

Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice

Yoshizaki, K., Adachi, K., Kataoka, S., Watanabe, A., Tabira, T., Takahashi, K. & Wakita, H., 01-04-2008, : : Experimental Neurology. 210, 2, p. 585-591 7 p.

研究成果: Article

102 引用 (Scopus)
13 引用 (Scopus)

Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model

Wakita, H., Ruetzler, C., Illoh, K. O., Chen, Y., Takanohashi, A., Spatz, M. & Hallenbeck, J. M., 01-02-2008, : : Journal of Cerebral Blood Flow and Metabolism. 28, 2, p. 341-353 13 p.

研究成果: Article

30 引用 (Scopus)
2007

Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion

Ohtani, R., Tomimoto, H., Wakita, H., Kitaguchi, H., Nakaji, K. & Takahashi, R., 02-03-2007, : : Brain Research. 1135, 1, p. 195-200 6 p.

研究成果: Article

18 引用 (Scopus)
141 引用 (Scopus)
2006

Small artery dementia in Japan: Radiological differences between CADASIL, leukoaraiosis and Binswanger's disease

Tomimoto, H., Ohtani, R., Wakita, H., Lin, J. X., Ihara, M., Miki, Y., Oshima, F., Murata, T., Ishibashi, K., Suenaga, T. & Mizuno, T., 01-02-2006, : : Dementia and Geriatric Cognitive Disorders. 21, 3, p. 162-169 8 p.

研究成果: Article

13 引用 (Scopus)
2005

Distribution of ischemic leukoaraiosis in MRI: A difference from white matter lesions in CADASIL

Tomimoto, H., Ohtani, R., Wakita, H., Lin, J. X., Miki, Y. & Mizuno, T., 01-02-2005, : : Brain and Nerve. 57, 2, p. 125-130 6 p.

研究成果: Article

5 引用 (Scopus)
2004

Effects of perindopril-based blood pressure lowering and of patient characteristics on the progression of silent brain infarct: The perindopril protection against recurrent stroke study (PROGRESS) CT substudy in Japan

Hasegawa, Y., Yamaguchi, T., Omae, T., Woodward, M., Chalmers, J., Takasaki, M., Iwamoto, T., Tohgi, H., Takahashi, H., Konno, S., Uchiyama, S., Kimura, Y., Hayakawa, I., Miyamori, T., Ishitsuka, T., Shiokawa, O., Nakano, M., Takenoyama, T., Fukiyama, K., Muratani, H. および47人, Hirose, G., Kataoka, S., Sakai, F., Kanda, T., Kitagawa, Y., Yoshitoshi, M., Shinohara, Y., Takizawa, S., Kazabari, S., Mihara, B., Kawagishi, Y., Makishita, H., Isomura, K., Tabata, K., Nakagawa, S., Okada, H., Takeda, A., Nakajima, K., Makino, M., Hirata, Y., Watahiki, Y., Kawamura, J., Yoshikawa, N., Takastuka, K., Akiguchi, I., Wakita, H., Tomimoto, H., Nakamura, S., Kohriyama, T., Hiwada, K., Shigematsu, Y., Yanagihara, T., Matsumoto, M., Ueda, H., Nishimaru, K., Setsu, K., Kobayashi, S., Yamaguchi, S., Hashimoto, S., Nakamura, M., Mitake, S., Uchida, M., Ishihara, N., Imai, N., Imaizumi, M., Hokezu, Y. & Satake, M., 01-03-2004, : : Hypertension Research. 27, 3, p. 147-156 10 p.

研究成果: Article

22 引用 (Scopus)

Ketamine attenuates hypocapnia-induced neuronal damage in the caudoputamen in a rat model of chronic cerebral hypoperfusion

Miyamoto, E., Nakao, S., Tomimoto, H., Wakita, H., Yamada, M., Masuzawa, M., Takahira, K., Sakamoto, S. & Shingu, K., 02-01-2004, : : Neuroscience Letters. 354, 1, p. 26-29 4 p.

研究成果: Article

12 引用 (Scopus)

Topographical and cytopathological lesion analysis of the white matter in Binswamger's disease brains

Akiguchi, I., Tomimoto, H., Wakita, H., Kawamoto, Y., Matsuo, A., Ohnishi, K., Watanabe, T. & Budka, H., 01-06-2004, : : Acta Neuropathologica. 107, 6, p. 563-570 8 p.

研究成果: Article

18 引用 (Scopus)

Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia

Ohtani, R., Tomimoto, H., Kondo, T., Wakita, H., Akiguchi, I., Shibasaki, H. & Okazaki, T., 08-10-2004, : : Brain Research. 1023, 1, p. 31-40 10 p.

研究成果: Article

50 引用 (Scopus)
2003

Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat

Tomimoto, H., Ihara, M., Wakita, H., Ohtani, R., Lin, J. X., Akiguchi, I., Kinoshita, M. & Shibasaki, H., 01-12-2003, : : Acta Neuropathologica. 106, 6, p. 527-534 8 p.

研究成果: Article

120 引用 (Scopus)

Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Lin, J. X., Ihara, M., Ohtani, R. & Shibata, M., 28-11-2003, : : Brain Research. 992, 1, p. 53-59 7 p.

研究成果: Article

59 引用 (Scopus)
2002

Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Matsuo, A., Lin, J. X., Ihara, M. & McGeer, P. L., 04-01-2002, : : Brain Research. 924, 1, p. 63-70 8 p.

研究成果: Article

141 引用 (Scopus)

Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion

Ueno, M., Tomimoto, H., Akiguchi, I., Wakita, H. & Sakamoto, H., 01-01-2002, : : Journal of Cerebral Blood Flow and Metabolism. 22, 1, p. 97-104 8 p.

研究成果: Article

98 引用 (Scopus)
2001

Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion

Miyamoto, E., Tomimoto, H., Nakao, S. I., Wakita, H., Akiguchi, I., Miyamoto, K. & Shingu, K., 01-01-2001, : : Stroke. 32, 12, p. 2920-2925 6 p.

研究成果: Article

20 引用 (Scopus)

Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter

Ihara, M., Tomimoto, H., Kinoshita, M., Oh, J., Noda, M., Wakita, H., Akiguchi, I. & Shibasaki, H., 01-01-2001, : : Journal of Cerebral Blood Flow and Metabolism. 21, 7, p. 828-834 7 p.

研究成果: Article

79 引用 (Scopus)

White matter lesions and alteration of vascular cell composition in the brain of spontaneously hypertensive rats

Lin, J. X., Tomimoto, H., Akiguchi, I., Wakita, H., Shibasaki, H. & Horie, R., 03-07-2001, : : Neuroreport. 12, 9, p. 1835-1839 5 p.

研究成果: Article

31 引用 (Scopus)
2000

Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans

Tomimoto, H., Akiguchi, I., Wakita, H., Lin, J. X. & Budka, H., 01-2000, : : Acta Neuropathologica. 99, 1, p. 26-30 5 p.

研究成果: Article

82 引用 (Scopus)

Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease

Tomimoto, H., Akiguchi, I., Ohtani, R., Yagi, H., Ogura, S. & Wakita, H., 11-2000, : : Internal Medicine. 39, 11, p. 966-969 4 p.

研究成果: Article

5 引用 (Scopus)

Vascular cell components of the medullary arteries in Binswanger's disease brains: A morphometric and immunoelectron microscopic study

Lin, J. X., Tomimoto, H., Akiguchi, I., Matsuo, A., Wakita, H., Shibasaki, H. & Budka, H., 01-01-2000, : : Stroke. 31, 8, p. 1838-1842 5 p.

研究成果: Article

33 引用 (Scopus)
1999

A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

Wakita, H., Tomimoto, H., Akiguchi, I., Lin, J. X., Miyamoto, K. & Oka, N., 14-05-1999, : : Neuroreport. 10, 7, p. 1461-1465 5 p.

研究成果: Article

44 引用 (Scopus)

Coagulation activation in patients with Binswanger disease

Tomimoto, H., Akiguchi, I., Wakita, H., Osaki, A., Hayashi, M. & Yamamoto, Y., 01-09-1999, : : Archives of Neurology. 56, 9, p. 1104-1108 5 p.

研究成果: Article

40 引用 (Scopus)

Cytopathological alterations and therapeutic approaches in Binswanger's disease

Akiguchi, I., Tomimoto, H., Wakita, H., Yamamoto, Y., Suenaga, T., Ueno, M. & Budka, H., 08-03-1999, : : Neuropathology. 19, 1, p. 119-128 10 p.

研究成果: Article

5 引用 (Scopus)

Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome

Akiguchi, I., Tomimoto, H., Kinoshita, M., Wakita, H., Osaki, A., Nishimura, M. & Kimura, J., 15-01-1999, : : Neurology. 52, 2, p. 398-401 4 p.

研究成果: Article

13 引用 (Scopus)

Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) [3]

Akiguchi, I., Tomimoto, H., Wakita, H., Osaki, A., Kimura, J. & Yamamoto, Y., 28-04-1999, : : Journal of Neurology. 246, 1, p. 58-60 3 p.

研究成果: Letter

2 引用 (Scopus)

Vascular changes in white matter lesions of Alzheimer's disease

Tomimoto, H., Akiguchi, I., Akiyama, H., Ikeda, K., Wakita, H., Lin, J. X. & Budka, H., 01-06-1999, : : Acta Neuropathologica. 97, 6, p. 629-634 6 p.

研究成果: Article

27 引用 (Scopus)
1998

Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia

Wakita, H., Tomimoto, H., Akiguchi, I. & Kimura, J., 04-05-1998, : : Brain Research. 792, 1, p. 105-113 9 p.

研究成果: Article

88 引用 (Scopus)
1997

Alterations in glia and axons in the brains of Binswanger's disease patients

Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H. & Budka, H., 07-1997, : : Stroke. 28, 7, p. 1423-1429 7 p.

研究成果: Article

103 引用 (Scopus)

Alterations of the blood-brain barrier and glial cells in white matter lesions in cerebrovascular and Alzheimer's disease patients [4] (multiple letters)

Leys, D., Henon, H., Pasquier, F., Tomimoto, H., Akiguchi, I. & Wakita, H., 24-04-1997, : : Stroke. 28, 4, p. 874-876 3 p.

研究成果: Letter

5 引用 (Scopus)

Blood-brain barrier dysfunction in Binswanger's disease; An immunohistochemical study

Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H. & Budka, H., 12-1997, : : Acta Neuropathologica. 95, 1, p. 78-84 7 p.

研究成果: Article

82 引用 (Scopus)

Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions

Tomimoto, H., Akiguchi, I., Matsuo, A., Terai, K., Wakita, H., Kimura, J., McGeer, P. L. & Budka, H., 01-01-1997, : : Neuroreport. 8, 17, p. 3727-3730 4 p.

研究成果: Article

5 引用 (Scopus)