• 8727 引用
  • 48 h指数
1985 …2020

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

1985

The uptake mechanism of indocyanine green byrat isolated hepatocytes

Kamma, O., Saito, K., Nagamura, Y., Ogitsu, N., Teshima, I., Ishiguro, I. & Ito, M., 01-01-1985, : : Japanese Journal of Clinical Chemistry. 14, 1, p. 41-47 7 p.

研究成果: Article

1986

Cholesterol uptake of isolated rat hepatocytes is accelerated by several kinds of phosphatidylcholine

Nagamura, Y., Sasaki, K., Ito, M., Saito, K., Ogitsu, N. & Ishiguro, I., 14-07-1986, : : FEBS Letters. 203, 1, p. 91-94 4 p.

研究成果: Article

2 引用 (Scopus)

Mode of L-tryptophan uptake into rat hepatocytes via trypsin-sensitive high-affinity transport system

Saito, K., Sasaki, E., Ohta, Y., Nagamura, Y. & Ishiguro, I., 01-12-1986, : : Biochemistry International. 13, 5, p. 873-883 11 p.

研究成果: Article

12 引用 (Scopus)
1988

The functions of receptors on the liver cells

Nagamura, Y., Ogitsu, N., Kitagawa, A., Kanma, O., Sasaki, K., Saito, K., Ishiguro, I. & Ito, M., 01-02-1988, : : Rinsho byori. The Japanese journal of clinical pathology. 36, 2, p. 145-149 5 p.

研究成果: Article

1989

The Relationship between Tryptophan Level in Serum and its Hepatic Uptake in Rats with Injured Liver by Carbon Tetrachloride

Uemusa, M., Saito, K., Ohta, Y., Ishiguro, I., Ito, M. & Nagamura, Y., 01-01-1989, : : Japanese Journal of Clinical Chemistry. 17, 4, p. 147-153 7 p.

研究成果: Article

1 引用 (Scopus)
1990

Relationship between L-tryptophan uptake and L-tryptophan, 2,3-dioxygenase activity in rat hepatocytes

Saito, K., Ohta, Y., Nagamura, Y., Sasaki, E. & Ishiguro, I., 07-02-1990, : : Biochemistry International. 20, 1, p. 71-80 10 p.

研究成果: Article

10 引用 (Scopus)
1991

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

Saito, K., Lackner, A., Markey, S. P. & Heyes, M. P., 01-02-1991, : : Brain Research. 540, 1-2, p. 353-356 4 p.

研究成果: Article

44 引用 (Scopus)

Characterization of L-tryptophan transport into liver in suckling rats

Saito, K., Nagamura, Y., Ohta, Y., Sasaki, E. & Ishiguro, I., 19-11-1991, : : Advances in Experimental Medicine and Biology. 294, p. 641-644 4 p.

研究成果: Article

Characterization of the L-tryptophan transport system in the liver of growing rats

Saito, K., Nagamura, Y., Ohta, Y., Sasaki, E. & Ishiguro, I., 1991, : : Life Sciences. 49, 7, p. 527-534 8 p.

研究成果: Article

8 引用 (Scopus)

Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Saito, K., Markey, S. P. & Heyes, M. P., 12-04-1991, : : Brain Research. 546, 1, p. 151-154 4 p.

研究成果: Article

68 引用 (Scopus)

Serum lipid and apolipoprotein levels in patients with chronic pancreatitis

Seishima, M., Torizawa, H., Saito, K., Nakamura, T., Murakami, N., Muto, Y., Nakamura, Y. & Noma, A., 11-1991, : : Rinsho byori. The Japanese journal of clinical pathology. 39, 11, p. 1191-1194 4 p.

研究成果: Article

3 引用 (Scopus)

Specific binding of L-tryptophan to serum albumin and its function in vivo

Sasaki, E., Saito, K., Ohta, Y., Ishiguro, I., Nagamura, Y., Shinohara, R., Takahashi, H. & Tagaya, O., 19-11-1991, : : Advances in Experimental Medicine and Biology. 294, p. 611-614 4 p.

研究成果: Article

7 引用 (Scopus)
1992

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

Saito, K., Markey, S. P. & Heyes, M. P., 11-1992, : : Neuroscience. 51, 1, p. 25-39 15 p.

研究成果: Article

160 引用 (Scopus)

Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Saito, K. & Markey, S. P., 01-01-1992, : : Biochemical Journal. 283, 3, p. 633-635 3 p.

研究成果: Article

197 引用 (Scopus)

Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients

Heyes, M. P., Brew, B. J., Saito, K., Quearry, B. J., Price, R. W., Lee, K., Bhalla, R. B., Der, M. & Markey, S. P., 09-1992, : : Journal of Neuroimmunology. 40, 1, p. 71-80 10 p.

研究成果: Article

121 引用 (Scopus)

Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain

Heyes, M. P., Saito, K., Jacobowitz, D., Markey, S. P., Takikawa, O. & Vickers, J. H., 01-01-1992, : : FASEB Journal. 6, 11, p. 2977-2989 13 p.

研究成果: Article

96 引用 (Scopus)

Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

Heyes, M. P., Saito, K., Crowley, J. S., Davis, L. E., Demitrack, M. A., Der, M., Dilling, L. A., Elia, J., Kruesi, M. J. P., Lackner, A., Larsen, S. A., Lee, K., Leonard, H. L., Markey, S. P., Martin, A., Milstein, S., Mouradian, M. M., Pranzatelli, M. R., Quearry, B. J., Salazar, A. および5人, Smith, M., Strauss, S. E., Sunderland, T., Swedo, S. W. & Tourtellotte, W. W., 01-10-1992, : : Brain. 115, 5, p. 1249-1273 25 p.

研究成果: Article

527 引用 (Scopus)

Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid

Heyes, M. P., Jordan, E. K., Lee, K., Saito, K., Frank, J. A., Snoy, P. J., Markey, S. P. & Gravell, M., 20-01-1992, : : Brain Research. 570, 1-2, p. 237-250 14 p.

研究成果: Article

82 引用 (Scopus)
1993

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)

Saito, K., Chen, C. Y., Masana, M., Crowley, J. S., Markey, S. P. & Heyes, M. P., 01-01-1993, : : Biochemical Journal. 291, 1, p. 11-14 4 p.

研究成果: Article

98 引用 (Scopus)

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation

Saito, K., Crowley, J. S., Markey, S. P. & Heyes, M. P., 01-01-1993, : : Journal of Biological Chemistry. 268, 21, p. 15496-15503 8 p.

研究成果: Article

167 引用 (Scopus)

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: Attenuation of synthesis from l-tryptophan by 6-chlorotryptophan and 4-cworo-3-hydroxy anthranilate

Heyes, M. P., Saito, K., Major, E. O., Milstien, S., Markey, S. P. & Vickers, J. H., 12-1993, : : Brain. 116, 6, p. 1425-1450 26 p.

研究成果: Article

149 引用 (Scopus)

Enhanced production of leukotriene B4 by peripheral blood mononuclear cells in patients with fulminant hepatitis

ASANO, F., MORIWAKI, H., SHIRATORI, Y., SHIMAZAKI, M., SAKAI, T., KOSHINO, Y., MURAKAMI, N., SUGIHARA, J., OHNISHI, H., SAITO, K. & MUTO, Y., 06-1993, : : Journal of Gastroenterology and Hepatology. 8, 3, p. 228-231 4 p.

研究成果: Article

6 引用 (Scopus)

Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

Blight, A. R., Saito, K. & Heyes, M. P., 31-12-1993, : : Brain Research. 632, 1-2, p. 314-316 3 p.

研究成果: Article

38 引用 (Scopus)

Induction of pterin synthesis is not required for cytokine-stimulated tryptophan metabolism

Sakai, N., Saito, K., Kaufman, S., Heyes, M. P. & Milstien, S., 01-01-1993, : : Biochemical Journal. 295, 2, p. 543-547 5 p.

研究成果: Article

12 引用 (Scopus)

Kynurenine 3-Hydroxylase in Brain: Species Activity Differences and Effect of Gerbil Cerebral Ischemia

Saito, K., Quearry, B. J., Saito, M., Nowak, T. S., Markey, S. P. & Heyes, M. P., 01-01-1993, : : Archives of Biochemistry and Biophysics. 307, 1, p. 104-109 6 p.

研究成果: Article

32 引用 (Scopus)

Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation

Saito, K., Nowak, T. S., Suyama, K., Quearry, B. J., Saito, M., Crowley, J. S., Markey, S. P. & Heyes, M. P., 12-1993, : : Journal of neurochemistry. 61, 6, p. 2061-2070 10 p.

研究成果: Article

103 引用 (Scopus)
153 引用 (Scopus)

Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine

Milstien, S., Sakai, N., Kaufman, S., Saito, K. & Heyes, M. P., 01-01-1993, : : Advances in Experimental Medicine and Biology. 338, p. 289-294 6 p.

研究成果: Article

2 引用 (Scopus)

Skin l-tryptophan-2,3-dioxygenase and rat hair growth

Ishiguro, I., Naito, J., Saito, K. & Nagamura, Y., 23-08-1993, : : FEBS Letters. 329, 1-2, p. 178-182 5 p.

研究成果: Article

25 引用 (Scopus)
1994
26 引用 (Scopus)

Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases

Milstien, S., Sakai, N., Brew, B. J., Krieger, C., Vickers, J. H., Saito, K. & Heyes, M. P., 01-09-1994, : : Journal of Neurochemistry. 63, 3, p. 1178-1180 3 p.

研究成果: Article

106 引用 (Scopus)

Facilitating Effect of Albumin on l-Tryptophan Transport into Isolated Rat Hepatocytes

Sasaki, E., Saito, K., Ohta, Y., Ishiguro, I., Nagamura, Y. & Shinohara, R., 01-01-1994, : : Journal of Clinical Biochemistry and Nutrition. 16, 1, p. 15-26 12 p.

研究成果: Article

Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures

Heyes, M. P., Saito, K., Devinsky, O. & Nadi, N. S., 03-1994, : : Epilepsia. 35, 2, p. 251-257 7 p.

研究成果: Article

48 引用 (Scopus)

Quantification of L‐tryptophan and L‐kynurenine by liquid chromatography/electron capture negative ion chemical ionization mass spectrometry

Boni, R. L., Simpson, J. T., Naritsin, D. B., Saito, K. & Markey, S. P., 01-01-1994, : : Biological Mass Spectrometry. 23, 1, p. 27-32 6 p.

研究成果: Article

14 引用 (Scopus)

Quinolinic acid immunoreactive cells in the choroid plexus, leptomeninges and brain vasculature of the immune-stimulated gerbil

Moffett, J. R., Espey, M. G., Saito, K. & Aryan Namboodiri, M. A., 10-1994, : : Journal of Neuroimmunology. 54, 1-2, p. 69-73 5 p.

研究成果: Article

19 引用 (Scopus)
1995

Alterations in cyclic AMP generation and G protein subunits following transient ischemia in gerbil hippocampus

Suyama, K., Saito, K., Chen, G., Pan, B. S., Manji, H. K. & Potter, W. Z., 01-01-1995, : : Journal of Cerebral Blood Flow and Metabolism. 15, 5, p. 877-885 9 p.

研究成果: Article

14 引用 (Scopus)
7 引用 (Scopus)

Increased human immunodeficiency virus (hiv) type 1 dnacontent and quinolinic acid concentration in brain tissues from patients with hiv encephalopathy

Sei, S., Saito, K., Stewart, S. K., Crowley, J. S., Brouwers, P., Kleiner, D. E., Katz, D. A., Pizzo, P. A. & Heyes, M. P., 01-01-1995, : : Journal of Infectious Diseases. 172, 3, p. 639-647 9 p.

研究成果: Article

51 引用 (Scopus)
24 引用 (Scopus)

Quinolinic acid accumulation and functional deficits following experimental spinal cord injury

Blight, A. R., Cohen, T. I., Saito, K. & Heyes, M. P., 01-06-1995, : : Brain. 118, 3, p. 735-752 18 p.

研究成果: Article

93 引用 (Scopus)

Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children

Heyes, M. P., Saito, K., Milstien, S. & Schiff, S. J., 01-01-1995, : : Journal of the Neurological Sciences. 133, 1-2, p. 112-118 7 p.

研究成果: Article

55 引用 (Scopus)

Quinolinic acid production is related to macrophage tropic isolates of HIV-1.

Brew, B. J., Corbeil, J., Pemberton, L., Evans, L., Saito, K., Penny, R., Cooper, D. A. & Heyes, M. P., 12-1995, : : Journal of neurovirology. 1, 5-6, p. 369-374 6 p.

研究成果: Article

45 引用 (Scopus)

The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy

Basile, A. S., Saito, K., Al-Mardini, H., Record, C. O., Hughes, R. D., Harrison, P., Williams, R., Li, Y. & Heyes, M. P., 03-1995, : : Gastroenterology. 108, 3, p. 818-823 6 p.

研究成果: Article

28 引用 (Scopus)
24 引用 (Scopus)
1996

4-Chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil

Saito, K., Seishima, M., Noma, A., Suyama, K., Markey, S. P. & Heyes, M. P., 01-12-1996, : : Advances in Experimental Medicine and Biology. 398, p. 407-411 5 p.

研究成果: Article

4 引用 (Scopus)

Cytokine and drug modulation of kynurenine pathway metabolism by blood mononuclear cells

Saito, K., Seishima, M., Noma, A., Markey, S. P. & Heyes, M. P., 01-12-1996, : : Advances in Experimental Medicine and Biology. 398, p. 161-165 5 p.

研究成果: Article

9 引用 (Scopus)

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

Saito, K., Suyama, K., Nishida, K., Sei, Y. & Basile, A. S., 15-03-1996, : : Neuroscience Letters. 206, 2-3, p. 149-152 4 p.

研究成果: Article

230 引用 (Scopus)

Highly sensitive ELISA for soluble Fas in serum: Increased soluble Fas in the elderly

Seishima, M., Takemura, M., Saito, K., Sano, H., Minatoguchi, S., Fujiwara, H., Hachiya, T. & Noma, A., 21-12-1996, : : Clinical Chemistry. 42, 12, p. 1911-1914 4 p.

研究成果: Article

40 引用 (Scopus)

Human microglia convert L-tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Achim, C. L., Wiley, C. A., Major, E. O., Saito, K. & Markey, S. P., 01-12-1996, : : Biochemical Journal. 320, 2, p. 595-597 3 p.

研究成果: Article

245 引用 (Scopus)