• 8934 引用
  • 48 h指数
1985 …2020

年単位の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

2016

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

Murakami, Y., Ishibashi, T., Tomita, E., Imamura, Y., Tashiro, T., Watcharanurak, K., Nishikawa, M., Takahashi, Y., Takakura, Y., Mitani, S., Fujigaki, H., Ohta, Y., Kubo, H., Mamiya, T., Nabeshima, T., Kim, H. C., Yamamoto, Y. & Saito, K., 20-07-2016, : : Scientific reports. 6, 29920.

研究成果: Article

24 引用 (Scopus)

High serum concentration of L-kynurenine predicts unfavorable outcomes in patients with acute myeloid leukemia

Mabuchi, R., Hara, T., Matsumoto, T., Shibata, Y., Nakamura, N., Nakamura, H., Kitagawa, J., Kanemura, N., Goto, N., Shimizu, M., Ito, H., Yamamoto, Y., Saito, K., Moriwaki, H. & Tsurumi, H., 02-01-2016, : : Leukemia and Lymphoma. 57, 1, p. 92-98 7 p.

研究成果: Article

18 引用 (Scopus)

Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia

Hara, T., Matsumoto, T., Shibata, Y., Nakamura, N., Nakamura, H., Ninomiya, S., Kitagawa, J., Nannya, Y., Shimizu, M., Ito, H., Saito, K. & Tsurumi, H., 01-09-2016, : : Leukemia and Lymphoma. 57, 9, p. 2208-2211 4 p.

研究成果: Letter

8 引用 (Scopus)

The Deficiency of indoleamine 2,3-Dioxygenase aggravates the CCl4 -Induced liver fibrosis in mice

Ogiso, H., Ito, H., Ando, T., Arioka, Y., Kanbe, A., Ando, K., Ishikawa, T., Saito, K., Hara, A., Moriwaki, H., Shimizu, M. & Seishima, M., 09-2016, : : PloS one. 11, 9, e0162183.

研究成果: Article

9 引用 (Scopus)

The role of indoleamine 2,3-dioxygenase in diethylnitrosamine-induced liver carcinogenesis

Shibata, Y., Hara, T., Nagano, J., Nakamura, N., Ohno, T., Ninomiya, S., Ito, H., Tanaka, T., Saito, K., Seishima, M., Shimizu, M., Moriwaki, H. & Tsurumi, H., 04-01-2016, : : PloS one. 11, 1, e0146279.

研究成果: Article

9 引用 (Scopus)
2015

Early microlesion of viral encephalitis confirmed by galectin-3 expression after a virus inoculation

Kobayashi, K., Niwa, M., Hoshi, M., Saito, K., Hisamatsu, K., Hatano, Y., Tomita, H., Miyazaki, T. & Hara, A., 01-04-2015, : : Neuroscience Letters. 592, p. 107-112 6 p.

研究成果: Article

8 引用 (Scopus)

Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice

Nakamura, N., Hara, T., Shimizu, M., Mabuchi, R., Nagano, J., Ohno, T., Kochi, T., Kubota, M., Shirakami, Y., Goto, N., Ito, H., Saito, K., Tanaka, T., Moriwaki, H. & Tsurumi, H., 13-09-2015, : : International Journal of Hematology. 102, 3, p. 327-334 8 p.

研究成果: Article

9 引用 (Scopus)

Expression of indoleamine 2,3-dioxygenase in leukemic cells indicates an unfavorable prognosis in acute myeloid leukemia patients with intermediate-risk cytogenetics

Fukuno, K., Hara, T., Tsurumi, H., Shibata, Y., Mabuchi, R., Nakamura, N., Kitagawa, J., Shimizu, M., Ito, H., Saito, K. & Moriwaki, H., 01-05-2015, : : Leukemia and Lymphoma. 56, 5, p. 1398-1405 8 p.

研究成果: Article

22 引用 (Scopus)

Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice

Takamatsu, M., Hirata, A., Ohtaki, H., Hoshi, M., Ando, T., Ito, H., Hatano, Y., Tomita, H., Kuno, T., Saito, K., Seishima, M. & Hara, A., 01-08-2015, : : Cancer science. 106, 8, p. 1008-1015 8 p.

研究成果: Article

27 引用 (Scopus)

Inhibition of indoleamine 2,3-dioxygenase activity accelerates skin wound healing

Ito, H., Ando, T., Ogiso, H., Arioka, Y., Saito, K. & Seishima, M., 01-06-2015, : : Biomaterials. 53, p. 221-228 8 p.

研究成果: Article

6 引用 (Scopus)

Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model

Ito, H., Ando, T., Arioka, Y., Saito, K. & Seishima, M., 01-04-2015, : : Immunology. 144, 4, p. 621-630 10 p.

研究成果: Article

17 引用 (Scopus)
2014

Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells

Hoshi, M., Osawa, Y., Ito, H., Ohtaki, H., Ando, T., Takamatsu, M., Hara, A., Saito, K. & Seishima, M., 2014, : : Infection and Immunity. 82, 11, p. 4487-4495 9 p.

研究成果: Article

16 引用 (Scopus)

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

Watcharanurak, K., Zang, L., Nishikawa, M., Yoshinaga, K., Yamamoto, Y., Takahashi, Y., Ando, M., Saito, K., Watanabe, Y. & Takakura, Y., 01-09-2014, : : Gene therapy. 21, 9, p. 794-801 8 p.

研究成果: Article

9 引用 (Scopus)

Effects of various phytochemicals on indoleamine 2,3-dioxygenase 1 activity: Galanal is a novel, competitive inhibitor of the enzyme

Yamamoto, R., Yamamoto, Y., Imai, S., Fukutomi, R., Ozawa, Y., Abe, M., Matuo, Y. & Saito, K., 12-02-2014, : : PloS one. 9, 2, e88789.

研究成果: Article

17 引用 (Scopus)

Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis

Yamamoto, Y., Takemura, M., Serrero, G., Hayashi, J., Yue, B., Tsuboi, A., Kubo, H., Mitsuhashi, T., Mannami, K., Sato, M., Matsunami, H., Matuo, Y. & Saito, K., 24-09-2014, : : Inflammation. 37, 5, p. 1806-1813 8 p.

研究成果: Article

36 引用 (Scopus)

Indoleamine 2,3-dioxygenase 1 is upregulated in activated microglia in mice cerebellum during acute viral encephalitis

Taguchi, A., Niwa, M., Hoshi, M., Saito, K., Masutani, T., Hisamatsu, K., Kobayashi, K., Hatano, Y., Tomita, H. & Hara, A., 03-04-2014, : : Neuroscience Letters. 564, p. 120-125 6 p.

研究成果: Article

12 引用 (Scopus)

Induction of hepatitis B virus surface antigen-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity

Ito, H., Ando, T., Ando, K., Ishikawa, T., Saito, K., Moriwaki, H. & Seishima, M., 08-2014, : : Immunology. 142, 4, p. 614-623 10 p.

研究成果: Article

21 引用 (Scopus)

Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis

Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Hoshi, M., Ando, T., Takamatsu, M., Hara, A., Moriwaki, H., Saito, K. & Seishima, M., 09-2014, : : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 9, p. 1464-1471 8 p.

研究成果: Article

9 引用 (Scopus)

Preface

Saito, K., 01-01-2014, : : Japanese Journal of Clinical Chemistry. 43, 4, 1 p.

研究成果: Editorial

2013

[Clinical significance of the measurement of serum cytokeratin-18 in patients with non-alcoholic steatohepatitis].

Watanabe, T., Takemura, M., Saito, K., Ito, H., Hattori, T., Sekine, A., Yamada, K., Kato, T., Tomita, E., Matsuoka, T. & Seishima, M., 01-2013, : : Unknown Journal. 61, 1, p. 19-24 6 p.

研究成果: Article

1 引用 (Scopus)

Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2

Kawasoe, M., Yamamoto, Y., Okawa, K., Funato, T., Takeda, M., Hara, T., Tsurumi, H., Moriwaki, H., Arioka, Y., Takemura, M., Matsunami, H., Markey, S. P. & Saito, K., 07-2013, : : Experimental Hematology. 41, 7, p. 597-603.e2

研究成果: Article

8 引用 (Scopus)

Effects of Indoleamine 2,3-Dioxygenase Deficiency on High-Fat Diet-Induced Hepatic Inflammation

Nagano, J., Shimizu, M., Hara, T., Shirakami, Y., Kochi, T., Nakamura, N., Ohtaki, H., Ito, H., Tanaka, T., Tsurumi, H., Saito, K., Seishima, M. & Moriwaki, H., 09-09-2013, : : PloS one. 8, 9, e73404.

研究成果: Article

25 引用 (Scopus)

IDO1 plays an immunosuppressive role in 2,4,6-Trinitrobenzene sulfate-induced colitis in mice

Takamatsu, M., Hirata, A., Ohtaki, H., Hoshi, M., Hatano, Y., Tomita, H., Kuno, T., Saito, K. & Hara, A., 15-09-2013, : : Journal of Immunology. 191, 6, p. 3057-3064 8 p.

研究成果: Article

30 引用 (Scopus)

IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network

Kim, B. K., Tran, H. Y. P., Shin, E. J., Lee, C., Chung, Y. H., Jeong, J. H., Bach, J. H., Kim, W. K., Park, D. H., Saito, K., Nabeshima, T. & Kim, H. C., 01-06-2013, : : Cellular Signalling. 25, 6, p. 1348-1360 13 p.

研究成果: Article

22 引用 (Scopus)
40 引用 (Scopus)

Species and cell types difference in tryptophan metabolism

Murakami, Y. & Saito, K., 27-08-2013, : : International Journal of Tryptophan Research. 6, SUPPL.1, p. 47-54 8 p.

研究成果: Review article

19 引用 (Scopus)

Supplementing healthy women with up to 5.0 g/d of l-tryptophan has no adverse effects

Hiratsuka, C., Fukuwatari, T., Sano, M., Saito, K., Sasaki, S. & Shibata, K., 01-06-2013, : : Journal of Nutrition. 143, 6, p. 859-866 8 p.

研究成果: Article

28 引用 (Scopus)

Tumor necrosis factor-alpha related signal pathways and neuronal diseases

Murakami, Y., Imamura, Y., Mitani, S., Hoshi, M., Arioka, Y., Yamamoto, Y., Seiyama, A. & Saito, K., 01-12-2013, Tumor Necrosis Factor: Structure, Enzyme Regulation and Role in Health and Disease. Nova Science Publishers, Inc., p. 1-28 28 p.

研究成果: Chapter

2012

(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells

Ogawa, K., Hara, T., Shimizu, M., Nagano, J., Ohno, T., Hoshi, M., Ito, H., Tsurumi, H., Saito, K., Seishima, M. & Moriwaki, H., 09-2012, : : Oncology Letters. 4, 3, p. 546-550 5 p.

研究成果: Article

30 引用 (Scopus)

Activation-Induced Cytidine Deaminase Alters the Subcellular Localization of Tet Family Proteins

Arioka, Y., Watanabe, A., Saito, K. & Yamada, Y., 17-09-2012, : : PloS one. 7, 9, e45031.

研究成果: Article

29 引用 (Scopus)

High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice

Ohtaki, H., Ito, H., Hoshi, M., Osawa, Y., Takamatsu, M., Hara, A., Ishikawa, T., Moriwaki, H., Saito, K. & Seishima, M., 2012, : : Scientific reports. 2, srep00367.

研究成果: Article

8 引用 (Scopus)

Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma

Ninomiya, S., Hara, T., Tsurumi, H., Goto, N., Saito, K., Seishima, M., Takami, T. & Moriwaki, H., 06-2012, : : Leukemia and Lymphoma. 53, 6, p. 1143-1145 3 p.

研究成果: Article

12 引用 (Scopus)

Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection

Murakami, Y., Hoshi, M., Hara, A., Takemura, M., Arioka, Y., Yamamoto, Y., Matsunami, H., Funato, T., Seishima, M. & Saito, K., 08-2012, : : Cytokine. 59, 2, p. 245-251 7 p.

研究成果: Article

23 引用 (Scopus)

L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice

Hoshi, M., Matsumoto, K., Ito, H., Ohtaki, H., Arioka, Y., Osawa, Y., Yamamoto, Y., Matsunami, H., Hara, A., Seishima, M. & Saito, K., 15-04-2012, : : Journal of Immunology. 188, 8, p. 3980-3987 8 p.

研究成果: Article

25 引用 (Scopus)

Posttranslational modification of indoleamine 2,3-dioxygenase

Fujigaki, H., Seishima, M. & Saito, K., 06-2012, : : Analytical and Bioanalytical Chemistry. 403, 7, p. 1777-1782 6 p.

研究成果: Article

16 引用 (Scopus)

Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice

Arioka, Y., Yamamoto, Y., Hoshi, M., Matsumoto, K., Takamatsu, M., Hara, A., Seishima, M. & Saito, K., 21-08-2012, : : Life Sciences. 91, 3-4, p. 100-106 7 p.

研究成果: Article

6 引用 (Scopus)

Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo

Tran, H. Y. P., Shin, E. J., Saito, K., Nguyen, X. K. T., Chung, Y. H., Jeong, J. H., Bach, J. H., Park, D. H., Yamada, K., Nabeshima, T., Yoneda, Y. & Kim, H. C., 01-04-2012, : : Free Radical Biology and Medicine. 52, 7, p. 1159-1174 16 p.

研究成果: Article

49 引用 (Scopus)
43 引用 (Scopus)

Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase

Ogawa, K., Hara, T., Shimizu, M., Ninomiya, S., Nagano, J., Sakai, H., Hoshi, M., Ito, H., Tsurumi, H., Saito, K., Seishima, M., Tanaka, T. & Moriwaki, H., 01-05-2012, : : Cancer Science. 103, 5, p. 951-958 8 p.

研究成果: Article

26 引用 (Scopus)
2011

Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP

Ninomiya, S., Hara, T., Tsurumi, H., Hoshi, M., Kanemura, N., Goto, N., Kasahara, S., Shimizu, M., Ito, H., Saito, K., Hirose, Y., Yamada, T., Takahashi, T., Seishima, M., Takami, T. & Moriwaki, H., 04-2011, : : Annals of Hematology. 90, 4, p. 409-416 8 p.

研究成果: Article

53 引用 (Scopus)

L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin

Osawa, Y., Kanamori, H., Seki, E., Hoshi, M., Ohtaki, H., Yasuda, Y., Ito, H., Suetsugu, A., Nagaki, M., Moriwaki, H., Saito, K. & Seishima, M., 07-10-2011, : : Journal of Biological Chemistry. 286, 40, p. 34800-34808 9 p.

研究成果: Article

37 引用 (Scopus)

Predicted expansion of the claudin multigene family

Mineta, K., Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K. & Tsukita, S., 18-02-2011, : : FEBS Letters. 585, 4, p. 606-612 7 p.

研究成果: Article

308 引用 (Scopus)
2010

[Soluble tumor necrosis factor receptor-I, II (sTNF-RI, -RII)].

Takemura, M., Saito, K., Sato, M. & Seishima, M., 07-2010, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 7, p. 183-186 4 p.

研究成果: Article

1 引用 (Scopus)

Ability of IDO to attenuate liver injury in α-galactosylceramide- induced hepatitis model

Ito, H., Hoshi, M., Ohtaki, H., Taguchi, A., Ando, K., Ishikawa, T., Osawa, Y., Hara, A., Moriwaki, H., Saito, K. & Seishima, M., 15-10-2010, : : Journal of Immunology. 185, 8, p. 4554-4560 7 p.

研究成果: Article

29 引用 (Scopus)

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: Relationship to CNS immune responses and depression

Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K. & Miller, A. H., 01-04-2010, : : Molecular Psychiatry. 15, 4, p. 393-403 11 p.

研究成果: Article

394 引用 (Scopus)

Dual role of the carboxyl-terminal region of pig liver l-kynurenine 3-monooxygenase: Mitochondrial-targeting signal and enzymatic activity

Hirai, K., Kuroyanagi, H., Tatebayashi, Y., Hayashi, Y., Hirabayashi-Takahashi, K., Saito, K., Haga, S., Uemura, T. & Izumi, S., 12-2010, : : Journal of Biochemistry. 148, 6, p. 639-650 12 p.

研究成果: Article

10 引用 (Scopus)