• 8934 引用
  • 48 h指数
1985 …2020

年単位の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

2004

Role of Tumor Necrosis Factor-α in Methamphetamine-Induced Drug Dependence and Neurotoxicity

Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M. H., Seto, A., Yoshimura, M., Kitaichi, K., Hasegawa, T., Saito, K., Yamada, Y., Seishima, M., Sekikawa, K., Kim, H. C. & Nabeshima, T., 03-03-2004, : : Journal of Neuroscience. 24, 9, p. 2212-2225 14 p.

研究成果: Article

138 引用 (Scopus)
2003

Clinical significance of MMP-3 in patients with rheumatoid arthritis: comparison with other inflammatory markers(IL-6, IL-8)

Hamakawa, H., Takemura, M., Sato, M., Shinohe, R., Koishi, H., Furuta, N., Ohta, H., Koike, N., Iwamoto, N., Yamada, Y., Wada, H., Saito, K. & Seishima, M., 01-2003, : : Rinsho byori. The Japanese journal of clinical pathology. 51, 1, p. 13-18 6 p.

研究成果: Article

4 引用 (Scopus)
2 引用 (Scopus)

Lack of interleukin-1ß decreases the severity of atherosclerosis in apoE-deficient mice

Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H. & Seishima, M., 01-04-2003, : : Arteriosclerosis, thrombosis, and vascular biology. 23, 4, p. 656-660 5 p.

研究成果: Article

472 引用 (Scopus)

Lack of tumor necrosis factor alpha induces impaired proliferation of hepatitis B virus-specific cytotoxic T lymphocytes

Kasahara, S., Ando, K., Saito, K., Sekikawa, K., Ito, H., Ishikawa, T., Ohnishi, H., Seishima, M., Kakumu, S. & Moriwaki, H., 01-02-2003, : : Journal of Virology. 77, 4, p. 2469-2476 8 p.

研究成果: Article

64 引用 (Scopus)

Role of Vα 14 NKT Cells in the Development of Impaired Liver Regeneration In Vivo

Ito, H., Ando, K., Nakayama, T., Taniguchi, M., Ezaki, T., Saito, K., Takemura, M., Sekikawa, K., Imawari, M., Seishima, M. & Moriwaki, H., 11-2003, : : Hepatology. 38, 5, p. 1116-1124 9 p.

研究成果: Article

60 引用 (Scopus)
20 引用 (Scopus)

TNF-α contributes to the development of allergic rhinitis in mice

Iwasaki, M., Saito, K., Takemura, M., Sekikawa, K., Fujii, H., Yamada, Y., Wada, H., Mizuta, K., Seishima, M. & Ito, Y., 01-07-2003, : : Journal of Allergy and Clinical Immunology. 112, 1, p. 134-140 7 p.

研究成果: Article

76 引用 (Scopus)

Tryptophan metabolism was accelerated by exercise in rat

Ito, Y., Yonekura, R., Maruta, K., Koike, T., Nakagami, Y., Shibata, K., Saito, K. & Nagamura, Y., 01-12-2003, : : Advances in Experimental Medicine and Biology. 527, p. 531-535 5 p.

研究成果: Article

19 引用 (Scopus)

Tumor necrosis factor-α from bone marrow-derived cells is not essential for the expression of adhesion molecules in lipopolysaccharide-induced nasal inflammation

Iwasaki, M., Saito, K., Sekikawa, K., Yamada, Y., Wada, H., Mizuta, K., Ito, Y. & Seishima, M., 07-02-2003, : : Cytokine. 21, 3, p. 129-136 8 p.

研究成果: Article

6 引用 (Scopus)
2002

CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning

Mizuno, M., Yamada, K., Maekawa, N., Saito, K., Seishima, M. & Nabeshima, T., 18-07-2002, : : Behavioural Brain Research. 133, 2, p. 135-141 7 p.

研究成果: Article

168 引用 (Scopus)

Immunohistochemical localization and mRNA expression of apolipoprotein A-I in rat spinal cord.

Fujii, H., Saito, K., Hamakawa, H., Maekawa, N., Fujigaki, S., Wada, H., Shimokawa, K., Seishima, M. & Takami, T., 2002, : : Journal of atherosclerosis and thrombosis. 9, 2, p. 93-98 6 p.

研究成果: Article

10 引用 (Scopus)

Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-α

Maekawa, N., Wada, H., Kanda, T., Niwa, T., Yamada, Y., Saito, K., Fujiwara, H., Sekikawa, K. & Seishima, M., 03-04-2002, : : Journal of the American College of Cardiology. 39, 7, p. 1229-1235 7 p.

研究成果: Article

143 引用 (Scopus)
108 引用 (Scopus)
2001

3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-γ

Morita, T., Saito, K., Takemura, M., Maekawa, N., Fujigaki, S., Fujii, H., Wada, H., Takeuchi, S., Noma, A. & Seishima, M., 22-05-2001, : : Annals of Clinical Biochemistry. 38, 3, p. 242-251 10 p.

研究成果: Article

66 引用 (Scopus)

Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-γ-independent mechanism

Fujigaki, S., Saito, K., Sekikawa, K., Tone, S., Takikawa, O., Fujii, H., Wada, H., Noma, A. & Seishima, M., 06-09-2001, : : European Journal of Immunology. 31, 8, p. 2313-2318 6 p.

研究成果: Article

164 引用 (Scopus)

Tumor necrosis factor-α (TNF-α) plays a protective role in acute viral myocarditis in mice: A study using mice lacking TNF-α

Wada, H., Saito, K., Kanda, T., Kobayashi, I., Fujii, H., Fujigaki, S., Maekawa, N., Takatsu, H., Fujiwara, H., Sekikawa, K. & Seishima, M., 06-02-2001, : : Circulation. 103, 5, p. 743-749 7 p.

研究成果: Article

93 引用 (Scopus)
2000

Evaluation of two different homogeneous assays for LDL-cholesterol in lipoprotein-X-positive serum

Fei, H., Maeda, S., Kirii, H., Fujigaki, S., Maekawa, N., Fujii, H., Wada, H., Saito, K. & Seishima, M., 01-01-2000, : : Clinical Chemistry. 46, 9, p. 1351-1356 6 p.

研究成果: Article

公開
32 引用 (Scopus)

Kynurenine concentration of serum was increased by exercise

Ito, Y., Saito, K., Maruta, K., Nakagami, Y., Koike, T., Oguri, Y. & Nagamura, Y., 01-12-2000, : : Advances in Experimental Medicine and Biology. 467, p. 717-722 6 p.

研究成果: Article

18 引用 (Scopus)

L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions

Morita, T., Saito, K., Takemura, M., Maekawa, N., Fujigaki, S., Fujii, H., Wada, H., Takeuchi, S., Noma, A. & Seishima, M., 01-01-2000, : : Advances in Experimental Medicine and Biology. 467, p. 559-563 5 p.

研究成果: Article

22 引用 (Scopus)

L-tryptophan metabolism in a disease - Defence or attack

Saito, K., Fujigaki, S. & Seishima, M., 01-01-2000, : : Japanese Journal of Clinical Chemistry. 29, 3, p. 103-112 10 p.

研究成果: Review article

Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency

Saito, K., Fujigaki, S., Heyes, M. P., Shibata, K., Takemura, M., Fujii, H., Wada, H., Noma, A. & Seishima, M., 2000, : : American Journal of Physiology - Renal Physiology. 279, 3 48-3, p. F565-F572

研究成果: Article

118 引用 (Scopus)

Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-α gene: Implications for emotional behavior

Yamada, K., Iida, R., Miyamoto, Y., Saito, K., Sekikawa, K., Seishima, M. & Nabeshima, T., 01-11-2000, : : Journal of Neuroimmunology. 111, 1-2, p. 131-138 8 p.

研究成果: Article

106 引用 (Scopus)

Quantification of anthranilic acid and its related enzyme activity in several different species

Fujigaki, S., Saito, K., Fujii, H., Wada, H. & Seishima, M., 01-12-2000, : : Advances in Experimental Medicine and Biology. 467, p. 625-628 4 p.

研究成果: Article

3 引用 (Scopus)

Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-α gene

Iida, R., Saito, K., Yamada, K., Basile, A. S., Sekikawa, K., Takemura, M., Fujii, H., Wada, H., Seishima, M. & Nabeshima, T., 16-05-2000, : : FASEB Journal. 14, 7, p. 1023-1031 9 p.

研究成果: Article

32 引用 (Scopus)
1999

Apolipoprotein A-I and E in cerebrospinal fluid

Urakami, K., Nakashima, K., Saito, K. & Seishima, M., 08-1999, : : Nippon rinsho. Japanese journal of clinical medicine. 57 Suppl, p. 158-161 4 p.

研究成果: Review article

Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS

Iida, R., Yamada, K., Mamiya, T., Saito, K., Seishima, M. & Nabeshima, T., 01-03-1999, : : Journal of Neuroimmunology. 95, 1-2, p. 65-72 8 p.

研究成果: Article

17 引用 (Scopus)
1998

Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis

Song, H., Seishima, M., Saito, K., Maeda, S., Takemura, M., Noma, A., Kondo, A., Manabe, M., Urakami, K. & Nakashima, K., 05-1998, : : Annals of Clinical Biochemistry. 35, 3, p. 408-414 7 p.

研究成果: Article

11 引用 (Scopus)

IL-1β and TNF-α suppress apolipoprotein (APO) E secretion and APO A-I expression in HepG2 cells

Song, H., Saito, K., Fujigaki, S., Noma, A., Ishiguro, H., Nagatsu, T. & Seishima, M., 04-1998, : : Cytokine. 10, 4, p. 275-280 6 p.

研究成果: Article

32 引用 (Scopus)

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

Heyes, M. P., Saito, K., Lackner, A., Wiley, C. A., Achim, C. L. & Markey, S. P., 08-07-1998, : : FASEB Journal. 12, 10, p. 881-896 16 p.

研究成果: Article

127 引用 (Scopus)

Species differences in L-tryptophan-kynurenine pathway metabolism: Quantification of anthranilic acid and its related enzymes

Fujigaki, S., Saito, K., Takemura, M., Fujii, H., Wada, H., Noma, A. & Seishima, M., 15-10-1998, : : Archives of Biochemistry and Biophysics. 358, 2, p. 329-335 7 p.

研究成果: Article

60 引用 (Scopus)
1997

Cerebrospinal fluid apo E and apo A-I concentrations in early- and late- onset Alzheimer's disease

Song, H., Saito, K., Seishima, M., Noma, A., Urakami, K. & Nakashima, K., 15-08-1997, : : Neuroscience Letters. 231, 3, p. 175-178 4 p.

研究成果: Article

48 引用 (Scopus)

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

Heyes, M. P., Chen, C. Y., Major, E. O. & Saito, K., 01-09-1997, : : Biochemical Journal. 326, 2, p. 351-356 6 p.

研究成果: Article

169 引用 (Scopus)

Increased serum soluble Fas (sFas) concentrations in HCV-positive patients with liver cirrhosis [1]

Seishima, M., Takemura, M., Saito, K., Ando, K. & Noma, A., 01-01-1997, : : Journal of Hepatology. 27, 2, p. 424-425 2 p.

研究成果: Letter

21 引用 (Scopus)

Marked increases in concentrations of apolipoprotein in the cerebrospinal fluid of poliovirus-infected macaques: Relations between apolipoprotein concentrations and severity of brain injury

Saito, K., Seishima, M., Heyes, M. P., Song, H., Fujigaki, S., Maeda, S., Vickers, J. H. & Noma, A., 01-01-1997, : : Biochemical Journal. 321, 1, p. 145-149 5 p.

研究成果: Article

23 引用 (Scopus)

Species heterogeneity between gerbils and rats: Quinolinate production by microgila and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation

Heyes, M. P., Saito, K., Chen, C. Y., Proescholdt, M. G., Nowak, T. S., Li, J., Beagles, K. E., Proescholdt, M. A., Zito, M. A., Kawai, K. & Markey, S. P., 01-10-1997, : : Journal of neurochemistry. 69, 4, p. 1519-1529 11 p.

研究成果: Article

69 引用 (Scopus)
1996
5 引用 (Scopus)

Cytokine and drug modulation of kynurenine pathway metabolism by blood mononuclear cells

Saito, K., Seishima, M., Noma, A., Markey, S. P. & Heyes, M. P., 01-12-1996, : : Advances in Experimental Medicine and Biology. 398, p. 161-165 5 p.

研究成果: Article

9 引用 (Scopus)

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

Saito, K., Suyama, K., Nishida, K., Sei, Y. & Basile, A. S., 15-03-1996, : : Neuroscience Letters. 206, 2-3, p. 149-152 4 p.

研究成果: Article

231 引用 (Scopus)

Highly sensitive ELISA for soluble Fas in serum: Increased soluble Fas in the elderly

Seishima, M., Takemura, M., Saito, K., Sano, H., Minatoguchi, S., Fujiwara, H., Hachiya, T. & Noma, A., 21-12-1996, : : Clinical Chemistry. 42, 12, p. 1911-1914 4 p.

研究成果: Article

40 引用 (Scopus)

Human microglia convert L-tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Achim, C. L., Wiley, C. A., Major, E. O., Saito, K. & Markey, S. P., 01-12-1996, : : Biochemical Journal. 320, 2, p. 595-597 3 p.

研究成果: Article

247 引用 (Scopus)

Kynurenine pathway metabolism in the galactosamine model of hepatic injury

Saito, K., Seishima, M., Noma, A., Nagamura, Y., Quearry, B. J., Markey, S. P. & Heyes, M. P., 01-01-1996, : : Advances in Experimental Medicine and Biology. 398, p. 421-424 4 p.

研究成果: Article

1 引用 (Scopus)

Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome

Sei, Y., Paul, I. A., Saito, K., Layar, R., Hartley, J. W., Morse, H. C., Skolnick, P. & Heyes, M. P., 01-01-1996, : : Journal of neurochemistry. 66, 1, p. 296-302 7 p.

研究成果: Article

36 引用 (Scopus)

Relationship between the level of serum L-tryptophan and its hepatic uptake and metabolism in rats with carbontetrachloride-induced liver cirrhosis

Ohta, Y., Uemura, M., Saito, K., Sasaki, E. & Ishiguro, I., 27-07-1996, : : Amino Acids. 10, 4, p. 369-378 10 p.

研究成果: Article

1 引用 (Scopus)
1995

Alterations in cyclic AMP generation and G protein subunits following transient ischemia in gerbil hippocampus

Suyama, K., Saito, K., Chen, G., Pan, B. S., Manji, H. K. & Potter, W. Z., 1995, : : Journal of Cerebral Blood Flow and Metabolism. 15, 5, p. 877-885 9 p.

研究成果: Article

14 引用 (Scopus)
7 引用 (Scopus)

Increased human immunodeficiency virus (hiv) type 1 dnacontent and quinolinic acid concentration in brain tissues from patients with hiv encephalopathy

Sei, S., Saito, K., Stewart, S. K., Crowley, J. S., Brouwers, P., Kleiner, D. E., Katz, D. A., Pizzo, P. A. & Heyes, M. P., 01-01-1995, : : Journal of Infectious Diseases. 172, 3, p. 639-647 9 p.

研究成果: Article

51 引用 (Scopus)
24 引用 (Scopus)

Quinolinic acid accumulation and functional deficits following experimental spinal cord injury

Blight, A. R., Cohen, T. I., Saito, K. & Heyes, M. P., 01-06-1995, : : Brain. 118, 3, p. 735-752 18 p.

研究成果: Article

93 引用 (Scopus)