• 8777 引用
  • 48 h指数
1985 …2020

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

フィルター
Article
2015

Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model

Ito, H., Ando, T., Arioka, Y., Saito, K. & Seishima, M., 01-04-2015, : : Immunology. 144, 4, p. 621-630 10 p.

研究成果: Article

15 引用 (Scopus)
2014

Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells

Hoshi, M., Osawa, Y., Ito, H., Ohtaki, H., Ando, T., Takamatsu, M., Hara, A., Saito, K. & Seishima, M., 01-01-2014, : : Infection and Immunity. 82, 11, p. 4487-4495 9 p.

研究成果: Article

16 引用 (Scopus)

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

Watcharanurak, K., Zang, L., Nishikawa, M., Yoshinaga, K., Yamamoto, Y., Takahashi, Y., Ando, M., Saito, K., Watanabe, Y. & Takakura, Y., 01-09-2014, : : Gene therapy. 21, 9, p. 794-801 8 p.

研究成果: Article

9 引用 (Scopus)

Effects of various phytochemicals on indoleamine 2,3-dioxygenase 1 activity: Galanal is a novel, competitive inhibitor of the enzyme

Yamamoto, R., Yamamoto, Y., Imai, S., Fukutomi, R., Ozawa, Y., Abe, M., Matuo, Y. & Saito, K., 12-02-2014, : : PloS one. 9, 2, e88789.

研究成果: Article

17 引用 (Scopus)

Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis

Yamamoto, Y., Takemura, M., Serrero, G., Hayashi, J., Yue, B., Tsuboi, A., Kubo, H., Mitsuhashi, T., Mannami, K., Sato, M., Matsunami, H., Matuo, Y. & Saito, K., 24-09-2014, : : Inflammation. 37, 5, p. 1806-1813 8 p.

研究成果: Article

34 引用 (Scopus)

Indoleamine 2,3-dioxygenase 1 is upregulated in activated microglia in mice cerebellum during acute viral encephalitis

Taguchi, A., Niwa, M., Hoshi, M., Saito, K., Masutani, T., Hisamatsu, K., Kobayashi, K., Hatano, Y., Tomita, H. & Hara, A., 03-04-2014, : : Neuroscience Letters. 564, p. 120-125 6 p.

研究成果: Article

12 引用 (Scopus)

Induction of hepatitis B virus surface antigen-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity

Ito, H., Ando, T., Ando, K., Ishikawa, T., Saito, K., Moriwaki, H. & Seishima, M., 08-2014, : : Immunology. 142, 4, p. 614-623 10 p.

研究成果: Article

20 引用 (Scopus)

Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis

Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Hoshi, M., Ando, T., Takamatsu, M., Hara, A., Moriwaki, H., Saito, K. & Seishima, M., 09-2014, : : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 9, p. 1464-1471 8 p.

研究成果: Article

9 引用 (Scopus)
2013

[Clinical significance of the measurement of serum cytokeratin-18 in patients with non-alcoholic steatohepatitis].

Watanabe, T., Takemura, M., Saito, K., Ito, H., Hattori, T., Sekine, A., Yamada, K., Kato, T., Tomita, E., Matsuoka, T. & Seishima, M., 01-2013, : : Unknown Journal. 61, 1, p. 19-24 6 p.

研究成果: Article

1 引用 (Scopus)

Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2

Kawasoe, M., Yamamoto, Y., Okawa, K., Funato, T., Takeda, M., Hara, T., Tsurumi, H., Moriwaki, H., Arioka, Y., Takemura, M., Matsunami, H., Markey, S. P. & Saito, K., 07-2013, : : Experimental Hematology. 41, 7, p. 597-603.e2

研究成果: Article

8 引用 (Scopus)

Effects of Indoleamine 2,3-Dioxygenase Deficiency on High-Fat Diet-Induced Hepatic Inflammation

Nagano, J., Shimizu, M., Hara, T., Shirakami, Y., Kochi, T., Nakamura, N., Ohtaki, H., Ito, H., Tanaka, T., Tsurumi, H., Saito, K., Seishima, M. & Moriwaki, H., 09-09-2013, : : PloS one. 8, 9, e73404.

研究成果: Article

24 引用 (Scopus)

IDO1 plays an immunosuppressive role in 2,4,6-Trinitrobenzene sulfate-induced colitis in mice

Takamatsu, M., Hirata, A., Ohtaki, H., Hoshi, M., Hatano, Y., Tomita, H., Kuno, T., Saito, K. & Hara, A., 15-09-2013, : : Journal of Immunology. 191, 6, p. 3057-3064 8 p.

研究成果: Article

29 引用 (Scopus)

IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network

Kim, B. K., Tran, H. Y. P., Shin, E. J., Lee, C., Chung, Y. H., Jeong, J. H., Bach, J. H., Kim, W. K., Park, D. H., Saito, K., Nabeshima, T. & Kim, H. C., 01-06-2013, : : Cellular Signalling. 25, 6, p. 1348-1360 13 p.

研究成果: Article

22 引用 (Scopus)

Supplementing healthy women with up to 5.0 g/d of l-tryptophan has no adverse effects

Hiratsuka, C., Fukuwatari, T., Sano, M., Saito, K., Sasaki, S. & Shibata, K., 01-06-2013, : : Journal of Nutrition. 143, 6, p. 859-866 8 p.

研究成果: Article

27 引用 (Scopus)
2012

(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells

Ogawa, K., Hara, T., Shimizu, M., Nagano, J., Ohno, T., Hoshi, M., Ito, H., Tsurumi, H., Saito, K., Seishima, M. & Moriwaki, H., 01-09-2012, : : Oncology Letters. 4, 3, p. 546-550 5 p.

研究成果: Article

29 引用 (Scopus)

Activation-Induced Cytidine Deaminase Alters the Subcellular Localization of Tet Family Proteins

Arioka, Y., Watanabe, A., Saito, K. & Yamada, Y., 17-09-2012, : : PloS one. 7, 9, e45031.

研究成果: Article

29 引用 (Scopus)

High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice

Ohtaki, H., Ito, H., Hoshi, M., Osawa, Y., Takamatsu, M., Hara, A., Ishikawa, T., Moriwaki, H., Saito, K. & Seishima, M., 27-04-2012, : : Scientific reports. 2, srep00367.

研究成果: Article

8 引用 (Scopus)

Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma

Ninomiya, S., Hara, T., Tsurumi, H., Goto, N., Saito, K., Seishima, M., Takami, T. & Moriwaki, H., 01-06-2012, : : Leukemia and Lymphoma. 53, 6, p. 1143-1145 3 p.

研究成果: Article

11 引用 (Scopus)

Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection

Murakami, Y., Hoshi, M., Hara, A., Takemura, M., Arioka, Y., Yamamoto, Y., Matsunami, H., Funato, T., Seishima, M. & Saito, K., 01-08-2012, : : Cytokine. 59, 2, p. 245-251 7 p.

研究成果: Article

22 引用 (Scopus)

L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice

Hoshi, M., Matsumoto, K., Ito, H., Ohtaki, H., Arioka, Y., Osawa, Y., Yamamoto, Y., Matsunami, H., Hara, A., Seishima, M. & Saito, K., 15-04-2012, : : Journal of Immunology. 188, 8, p. 3980-3987 8 p.

研究成果: Article

25 引用 (Scopus)

Posttranslational modification of indoleamine 2,3-dioxygenase

Fujigaki, H., Seishima, M. & Saito, K., 01-06-2012, : : Analytical and Bioanalytical Chemistry. 403, 7, p. 1777-1782 6 p.

研究成果: Article

16 引用 (Scopus)

Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice

Arioka, Y., Yamamoto, Y., Hoshi, M., Matsumoto, K., Takamatsu, M., Hara, A., Seishima, M. & Saito, K., 21-08-2012, : : Life Sciences. 91, 3-4, p. 100-106 7 p.

研究成果: Article

6 引用 (Scopus)

Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo

Tran, H. Y. P., Shin, E. J., Saito, K., Nguyen, X. K. T., Chung, Y. H., Jeong, J. H., Bach, J. H., Park, D. H., Yamada, K., Nabeshima, T., Yoneda, Y. & Kim, H. C., 01-04-2012, : : Free Radical Biology and Medicine. 52, 7, p. 1159-1174 16 p.

研究成果: Article

49 引用 (Scopus)
43 引用 (Scopus)

Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase

Ogawa, K., Hara, T., Shimizu, M., Ninomiya, S., Nagano, J., Sakai, H., Hoshi, M., Ito, H., Tsurumi, H., Saito, K., Seishima, M., Tanaka, T. & Moriwaki, H., 01-05-2012, : : Cancer Science. 103, 5, p. 951-958 8 p.

研究成果: Article

26 引用 (Scopus)
2011

Indoleamine 2,3-dioxygenase in tumor tissue indicates prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP

Ninomiya, S., Hara, T., Tsurumi, H., Hoshi, M., Kanemura, N., Goto, N., Kasahara, S., Shimizu, M., Ito, H., Saito, K., Hirose, Y., Yamada, T., Takahashi, T., Seishima, M., Takami, T. & Moriwaki, H., 01-04-2011, : : Annals of Hematology. 90, 4, p. 409-416 8 p.

研究成果: Article

51 引用 (Scopus)

L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin

Osawa, Y., Kanamori, H., Seki, E., Hoshi, M., Ohtaki, H., Yasuda, Y., Ito, H., Suetsugu, A., Nagaki, M., Moriwaki, H., Saito, K. & Seishima, M., 07-10-2011, : : Journal of Biological Chemistry. 286, 40, p. 34800-34808 9 p.

研究成果: Article

34 引用 (Scopus)

Predicted expansion of the claudin multigene family

Mineta, K., Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K. & Tsukita, S., 18-02-2011, : : FEBS Letters. 585, 4, p. 606-612 7 p.

研究成果: Article

296 引用 (Scopus)
2010

[Soluble tumor necrosis factor receptor-I, II (sTNF-RI, -RII)].

Takemura, M., Saito, K., Sato, M. & Seishima, M., 07-2010, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 7, p. 183-186 4 p.

研究成果: Article

1 引用 (Scopus)

Ability of IDO to attenuate liver injury in α-galactosylceramide- induced hepatitis model

Ito, H., Hoshi, M., Ohtaki, H., Taguchi, A., Ando, K., Ishikawa, T., Osawa, Y., Hara, A., Moriwaki, H., Saito, K. & Seishima, M., 15-10-2010, : : Journal of Immunology. 185, 8, p. 4554-4560 7 p.

研究成果: Article

29 引用 (Scopus)

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: Relationship to CNS immune responses and depression

Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K. & Miller, A. H., 01-04-2010, : : Molecular Psychiatry. 15, 4, p. 393-403 11 p.

研究成果: Article

384 引用 (Scopus)

Dual role of the carboxyl-terminal region of pig liver l-kynurenine 3-monooxygenase: Mitochondrial-targeting signal and enzymatic activity

Hirai, K., Kuroyanagi, H., Tatebayashi, Y., Hayashi, Y., Hirabayashi-Takahashi, K., Saito, K., Haga, S., Uemura, T. & Izumi, S., 01-12-2010, : : Journal of Biochemistry. 148, 6, p. 639-650 12 p.

研究成果: Article

9 引用 (Scopus)

Genetic ablation of Tnfα demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis

Sakai, H., Yamada, Y., Shimizu, M., Saito, K., Moriwaki, H. & Hara, A., 01-03-2010, : : Chemico-Biological Interactions. 184, 3, p. 423-430 8 p.

研究成果: Article

16 引用 (Scopus)

Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy

Suzuki, M., Fujii, H., Fujigaki, H., Shinoda, S., Takahashi, K., Saito, K., Wada, H., Kimoto, M., Kondo, N. & Seishima, M., 01-01-2010, : : Allergology International. 59, 2, p. 175-183 9 p.

研究成果: Article

10 引用 (Scopus)

Serum concentration of L-kynurenine predicts the clinical outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP

Yoshikawa, T., Hara, T., Tsurumi, H., Goto, N., Hoshi, M., Kitagawa, J., Kanemura, N., Kasahara, S., Ito, H., Takemura, M., Saito, K., Seishima, M., Takami, T. & Moriwaki, H., 01-04-2010, : : European Journal of Haematology. 84, 4, p. 304-309 6 p.

研究成果: Article

45 引用 (Scopus)

The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse

Hoshi, M., Saito, K., Hara, A., Taguchi, A., Ohtaki, H., Tanaka, R., Fujigaki, H., Osawa, Y., Takemura, M., Matsunami, H., Ito, H. & Seishima, M., 15-09-2010, : : Journal of Immunology. 185, 6, p. 3305-3312 8 p.

研究成果: Article

57 引用 (Scopus)
2009

Effects of Wooden and Vinyl Interior Finishes on Stress Reduction Estimate by biological and psychological parameters

Saito, Y., Nishimaki, M., Tatsumi, Y., Ono, S., Kinoshita, M., Sasayama, S. & Saito, K., 01-01-2009, : : Mokuzai Gakkaishi/Journal of the Japan Wood Research Society. 55, 2, p. 101-107 7 p.

研究成果: Article

1 引用 (Scopus)

Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity

Hoshi, M., Ito, H., Fujigaki, H., Takemura, M., Takahashi, T., Tomita, E., Ohyama, M., Tanaka, R., Saito, K. & Seishima, M., 01-01-2009, : : Leukemia Research. 33, 1, p. 39-45 7 p.

研究成果: Article

42 引用 (Scopus)

Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Vα14 NKT cells

Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Hoshi, M., Tanaka, R., Osawa, Y., Yokochi, T., Moriwaki, H., Saito, K. & Seishima, M., 13-11-2009, : : Biochemical and Biophysical Research Communications. 389, 2, p. 229-234 6 p.

研究成果: Article

6 引用 (Scopus)

Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-γ-independent pathway following transient global ischemia in mouse

Hoshi, M., Saito, K., Murakami, Y., Taguchi, A., Fujigaki, H., Tanaka, R., Takemura, M., Ito, H., Hara, A. & Seishima, M., 01-03-2009, : : Neuroscience Research. 63, 3, p. 194-198 5 p.

研究成果: Article

16 引用 (Scopus)

Role of TNF-α produced by nonantigen-specific cells in a fulminant hepatitis mouse model

Ito, H., Ando, K., Ishikawa, T., Saito, K., Takemura, M., Imawari, M., Moriwaki, H. & Seishima, M., 01-01-2009, : : Journal of Immunology. 182, 1, p. 391-397 7 p.

研究成果: Article

28 引用 (Scopus)

Statin-induced Ca(2+) release was increased in B lymphocytes in patients who showed elevated serum creatine kinase during statin treatment.

Hattori, T., Saito, K., Takemura, M., Ito, H., Ohta, H., Wada, H., Sei, Y., Kawamura, M. & Seishima, M., 01-12-2009, : : Journal of Atherosclerosis and Thrombosis. 16, 6, p. 870-877 8 p.

研究成果: Article

3 引用 (Scopus)

Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo

Iwamoto, N., Ito, H., Ando, K., Ishikawa, T., Hara, A., Taguchi, A., Saito, K., Takemura, M., Imawari, M., Moriwaki, H. & Seishima, M., 19-01-2009, : : Liver International. 29, 2, p. 277-283 7 p.

研究成果: Article

21 引用 (Scopus)

Vα14 NKT cells activated by alpha-galactosylceramide augment lipopolysaccharide-induced nitric oxide production in mouse intra-hepatic lymphocytes

Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Saito, K., Imawari, M., Yokochi, T., Moriwaki, H. & Seishima, M., 16-01-2009, : : Biochemical and Biophysical Research Communications. 378, 3, p. 579-583 5 p.

研究成果: Article

11 引用 (Scopus)
2008

Cytokine profiles in mice with arthritis induced by anti-type II collagen monoclonal antibody plus lipopolysaccharide

Shinohe, R., Sato, M., Takemura, M., Shimizu, K., Koishi, H., Tanaka, R., Saito, K. & Seishima, M., 22-02-2008, : : Japanese Journal of Clinical Chemistry. 37, 1, p. 53-62 10 p.

研究成果: Article

1 引用 (Scopus)

Localization and spatiotemporal expression of IDO following transient forebrain ischemia in gerbils

Taguchi, A., Hara, A., Saito, K., Hoshi, M., Niwa, M., Seishima, M. & Mori, H., 27-06-2008, : : Brain Research. 1217, p. 78-85 8 p.

研究成果: Article

10 引用 (Scopus)
20 引用 (Scopus)

Proteomic analysis of autoantibodies in neuropsychiatric systemic lupus erythematosus patient with white matter hyperintensities on brain MRI

Kimura, A., Sakurai, T., Tanaka, Y., Hozumi, I., Takahashi, K., Takemura, M., Saito, K., Seishima, M. & Inuzuka, T., 11-04-2008, : : Lupus. 17, 1, p. 16-20 5 p.

研究成果: Article

21 引用 (Scopus)