• 8777 引用
  • 48 h指数
1985 …2020

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

フィルター
Article
2000

L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions

Morita, T., Saito, K., Takemura, M., Maekawa, N., Fujigaki, S., Fujii, H., Wada, H., Takeuchi, S., Noma, A. & Seishima, M., 01-01-2000, : : Advances in Experimental Medicine and Biology. 467, p. 559-563 5 p.

研究成果: Article

22 引用 (Scopus)

Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency

Saito, K., Fujigaki, S., Heyes, M. P., Shibata, K., Takemura, M., Fujii, H., Wada, H., Noma, A. & Seishima, M., 05-10-2000, : : American Journal of Physiology - Renal Physiology. 279, 3 48-3, p. F565-F572

研究成果: Article

117 引用 (Scopus)

Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-α gene: Implications for emotional behavior

Yamada, K., Iida, R., Miyamoto, Y., Saito, K., Sekikawa, K., Seishima, M. & Nabeshima, T., 01-11-2000, : : Journal of Neuroimmunology. 111, 1-2, p. 131-138 8 p.

研究成果: Article

103 引用 (Scopus)

Quantification of anthranilic acid and its related enzyme activity in several different species

Fujigaki, S., Saito, K., Fujii, H., Wada, H. & Seishima, M., 01-12-2000, : : Advances in Experimental Medicine and Biology. 467, p. 625-628 4 p.

研究成果: Article

3 引用 (Scopus)

Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-α gene

Iida, R., Saito, K., Yamada, K., Basile, A. S., Sekikawa, K., Takemura, M., Fujii, H., Wada, H., Seishima, M. & Nabeshima, T., 16-05-2000, : : FASEB Journal. 14, 7, p. 1023-1031 9 p.

研究成果: Article

32 引用 (Scopus)
1999

Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS

Iida, R., Yamada, K., Mamiya, T., Saito, K., Seishima, M. & Nabeshima, T., 01-03-1999, : : Journal of Neuroimmunology. 95, 1-2, p. 65-72 8 p.

研究成果: Article

17 引用 (Scopus)
1998

Apo A-I and apo E concentrations in cerebrospinal fluids of patients with acute meningitis

Song, H., Seishima, M., Saito, K., Maeda, S., Takemura, M., Noma, A., Kondo, A., Manabe, M., Urakami, K. & Nakashima, K., 05-1998, : : Annals of Clinical Biochemistry. 35, 3, p. 408-414 7 p.

研究成果: Article

11 引用 (Scopus)

IL-1β and TNF-α suppress apolipoprotein (APO) E secretion and APO A-I expression in HepG2 cells

Song, H., Saito, K., Fujigaki, S., Noma, A., Ishiguro, H., Nagatsu, T. & Seishima, M., 04-1998, : : Cytokine. 10, 4, p. 275-280 6 p.

研究成果: Article

32 引用 (Scopus)

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

Heyes, M. P., Saito, K., Lackner, A., Wiley, C. A., Achim, C. L. & Markey, S. P., 08-07-1998, : : FASEB Journal. 12, 10, p. 881-896 16 p.

研究成果: Article

127 引用 (Scopus)

Species differences in L-tryptophan-kynurenine pathway metabolism: Quantification of anthranilic acid and its related enzymes

Fujigaki, S., Saito, K., Takemura, M., Fujii, H., Wada, H., Noma, A. & Seishima, M., 15-10-1998, : : Archives of Biochemistry and Biophysics. 358, 2, p. 329-335 7 p.

研究成果: Article

60 引用 (Scopus)
1997

Cerebrospinal fluid apo E and apo A-I concentrations in early- and late- onset Alzheimer's disease

Song, H., Saito, K., Seishima, M., Noma, A., Urakami, K. & Nakashima, K., 15-08-1997, : : Neuroscience Letters. 231, 3, p. 175-178 4 p.

研究成果: Article

48 引用 (Scopus)

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

Heyes, M. P., Chen, C. Y., Major, E. O. & Saito, K., 01-09-1997, : : Biochemical Journal. 326, 2, p. 351-356 6 p.

研究成果: Article

168 引用 (Scopus)

Marked increases in concentrations of apolipoprotein in the cerebrospinal fluid of poliovirus-infected macaques: Relations between apolipoprotein concentrations and severity of brain injury

Saito, K., Seishima, M., Heyes, M. P., Song, H., Fujigaki, S., Maeda, S., Vickers, J. H. & Noma, A., 01-01-1997, : : Biochemical Journal. 321, 1, p. 145-149 5 p.

研究成果: Article

23 引用 (Scopus)

Species heterogeneity between gerbils and rats: Quinolinate production by microgila and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation

Heyes, M. P., Saito, K., Chen, C. Y., Proescholdt, M. G., Nowak, T. S., Li, J., Beagles, K. E., Proescholdt, M. A., Zito, M. A., Kawai, K. & Markey, S. P., 01-10-1997, : : Journal of neurochemistry. 69, 4, p. 1519-1529 11 p.

研究成果: Article

68 引用 (Scopus)
1996

4-Chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil

Saito, K., Seishima, M., Noma, A., Suyama, K., Markey, S. P. & Heyes, M. P., 01-12-1996, : : Advances in Experimental Medicine and Biology. 398, p. 407-411 5 p.

研究成果: Article

4 引用 (Scopus)

Cytokine and drug modulation of kynurenine pathway metabolism by blood mononuclear cells

Saito, K., Seishima, M., Noma, A., Markey, S. P. & Heyes, M. P., 01-12-1996, : : Advances in Experimental Medicine and Biology. 398, p. 161-165 5 p.

研究成果: Article

9 引用 (Scopus)

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

Saito, K., Suyama, K., Nishida, K., Sei, Y. & Basile, A. S., 15-03-1996, : : Neuroscience Letters. 206, 2-3, p. 149-152 4 p.

研究成果: Article

230 引用 (Scopus)

Highly sensitive ELISA for soluble Fas in serum: Increased soluble Fas in the elderly

Seishima, M., Takemura, M., Saito, K., Sano, H., Minatoguchi, S., Fujiwara, H., Hachiya, T. & Noma, A., 21-12-1996, : : Clinical Chemistry. 42, 12, p. 1911-1914 4 p.

研究成果: Article

40 引用 (Scopus)

Human microglia convert L-tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Achim, C. L., Wiley, C. A., Major, E. O., Saito, K. & Markey, S. P., 01-12-1996, : : Biochemical Journal. 320, 2, p. 595-597 3 p.

研究成果: Article

245 引用 (Scopus)

Kynurenine pathway metabolism in the galactosamine model of hepatic injury

Saito, K., Seishima, M., Noma, A., Nagamura, Y., Quearry, B. J., Markey, S. P. & Heyes, M. P., 01-12-1996, : : Advances in Experimental Medicine and Biology. 398, p. 421-424 4 p.

研究成果: Article

1 引用 (Scopus)

Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome

Sei, Y., Paul, I. A., Saito, K., Layar, R., Hartley, J. W., Morse, H. C., Skolnick, P. & Heyes, M. P., 01-01-1996, : : Journal of neurochemistry. 66, 1, p. 296-302 7 p.

研究成果: Article

37 引用 (Scopus)

Relationship between the level of serum L-tryptophan and its hepatic uptake and metabolism in rats with carbontetrachloride-induced liver cirrhosis

Ohta, Y., Uemura, M., Saito, K., Sasaki, E. & Ishiguro, I., 27-07-1996, : : Amino Acids. 10, 4, p. 369-378 10 p.

研究成果: Article

1 引用 (Scopus)
1995

Alterations in cyclic AMP generation and G protein subunits following transient ischemia in gerbil hippocampus

Suyama, K., Saito, K., Chen, G., Pan, B. S., Manji, H. K. & Potter, W. Z., 01-01-1995, : : Journal of Cerebral Blood Flow and Metabolism. 15, 5, p. 877-885 9 p.

研究成果: Article

14 引用 (Scopus)

Increased human immunodeficiency virus (hiv) type 1 dnacontent and quinolinic acid concentration in brain tissues from patients with hiv encephalopathy

Sei, S., Saito, K., Stewart, S. K., Crowley, J. S., Brouwers, P., Kleiner, D. E., Katz, D. A., Pizzo, P. A. & Heyes, M. P., 01-01-1995, : : Journal of Infectious Diseases. 172, 3, p. 639-647 9 p.

研究成果: Article

51 引用 (Scopus)
24 引用 (Scopus)

Quinolinic acid accumulation and functional deficits following experimental spinal cord injury

Blight, A. R., Cohen, T. I., Saito, K. & Heyes, M. P., 01-06-1995, : : Brain. 118, 3, p. 735-752 18 p.

研究成果: Article

93 引用 (Scopus)

Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children

Heyes, M. P., Saito, K., Milstien, S. & Schiff, S. J., 01-01-1995, : : Journal of the Neurological Sciences. 133, 1-2, p. 112-118 7 p.

研究成果: Article

55 引用 (Scopus)

Quinolinic acid production is related to macrophage tropic isolates of HIV-1.

Brew, B. J., Corbeil, J., Pemberton, L., Evans, L., Saito, K., Penny, R., Cooper, D. A. & Heyes, M. P., 12-1995, : : Journal of neurovirology. 1, 5-6, p. 369-374 6 p.

研究成果: Article

45 引用 (Scopus)

The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy

Basile, A. S., Saito, K., Al-Mardini, H., Record, C. O., Hughes, R. D., Harrison, P., Williams, R., Li, Y. & Heyes, M. P., 03-1995, : : Gastroenterology. 108, 3, p. 818-823 6 p.

研究成果: Article

28 引用 (Scopus)
24 引用 (Scopus)
1994
26 引用 (Scopus)

Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases

Milstien, S., Sakai, N., Brew, B. J., Krieger, C., Vickers, J. H., Saito, K. & Heyes, M. P., 09-1994, : : Journal of neurochemistry. 63, 3, p. 1178-1180 3 p.

研究成果: Article

106 引用 (Scopus)

Facilitating Effect of Albumin on l-Tryptophan Transport into Isolated Rat Hepatocytes

Sasaki, E., Saito, K., Ohta, Y., Ishiguro, I., Nagamura, Y. & Shinohara, R., 01-01-1994, : : Journal of Clinical Biochemistry and Nutrition. 16, 1, p. 15-26 12 p.

研究成果: Article

Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures

Heyes, M. P., Saito, K., Devinsky, O. & Nadi, N. S., 03-1994, : : Epilepsia. 35, 2, p. 251-257 7 p.

研究成果: Article

48 引用 (Scopus)

Quantification of L‐tryptophan and L‐kynurenine by liquid chromatography/electron capture negative ion chemical ionization mass spectrometry

Boni, R. L., Simpson, J. T., Naritsin, D. B., Saito, K. & Markey, S. P., 01-01-1994, : : Biological Mass Spectrometry. 23, 1, p. 27-32 6 p.

研究成果: Article

14 引用 (Scopus)

Quinolinic acid immunoreactive cells in the choroid plexus, leptomeninges and brain vasculature of the immune-stimulated gerbil

Moffett, J. R., Espey, M. G., Saito, K. & Aryan Namboodiri, M. A., 10-1994, : : Journal of Neuroimmunology. 54, 1-2, p. 69-73 5 p.

研究成果: Article

19 引用 (Scopus)
1993

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)

Saito, K., Chen, C. Y., Masana, M., Crowley, J. S., Markey, S. P. & Heyes, M. P., 01-01-1993, : : Biochemical Journal. 291, 1, p. 11-14 4 p.

研究成果: Article

98 引用 (Scopus)

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation

Saito, K., Crowley, J. S., Markey, S. P. & Heyes, M. P., 01-01-1993, : : Journal of Biological Chemistry. 268, 21, p. 15496-15503 8 p.

研究成果: Article

168 引用 (Scopus)

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: Attenuation of synthesis from l-tryptophan by 6-chlorotryptophan and 4-cworo-3-hydroxy anthranilate

Heyes, M. P., Saito, K., Major, E. O., Milstien, S., Markey, S. P. & Vickers, J. H., 12-1993, : : Brain. 116, 6, p. 1425-1450 26 p.

研究成果: Article

149 引用 (Scopus)

Enhanced production of leukotriene B4 by peripheral blood mononuclear cells in patients with fulminant hepatitis

ASANO, F., MORIWAKI, H., SHIRATORI, Y., SHIMAZAKI, M., SAKAI, T., KOSHINO, Y., MURAKAMI, N., SUGIHARA, J., OHNISHI, H., SAITO, K. & MUTO, Y., 06-1993, : : Journal of Gastroenterology and Hepatology. 8, 3, p. 228-231 4 p.

研究成果: Article

6 引用 (Scopus)

Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

Blight, A. R., Saito, K. & Heyes, M. P., 31-12-1993, : : Brain Research. 632, 1-2, p. 314-316 3 p.

研究成果: Article

38 引用 (Scopus)

Induction of pterin synthesis is not required for cytokine-stimulated tryptophan metabolism

Sakai, N., Saito, K., Kaufman, S., Heyes, M. P. & Milstien, S., 01-01-1993, : : Biochemical Journal. 295, 2, p. 543-547 5 p.

研究成果: Article

12 引用 (Scopus)

Kynurenine 3-Hydroxylase in Brain: Species Activity Differences and Effect of Gerbil Cerebral Ischemia

Saito, K., Quearry, B. J., Saito, M., Nowak, T. S., Markey, S. P. & Heyes, M. P., 01-01-1993, : : Archives of Biochemistry and Biophysics. 307, 1, p. 104-109 6 p.

研究成果: Article

32 引用 (Scopus)

Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation

Saito, K., Nowak, T. S., Suyama, K., Quearry, B. J., Saito, M., Crowley, J. S., Markey, S. P. & Heyes, M. P., 12-1993, : : Journal of neurochemistry. 61, 6, p. 2061-2070 10 p.

研究成果: Article

103 引用 (Scopus)
153 引用 (Scopus)

Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine

Milstien, S., Sakai, N., Kaufman, S., Saito, K. & Heyes, M. P., 01-01-1993, : : Advances in Experimental Medicine and Biology. 338, p. 289-294 6 p.

研究成果: Article

2 引用 (Scopus)

Skin l-tryptophan-2,3-dioxygenase and rat hair growth

Ishiguro, I., Naito, J., Saito, K. & Nagamura, Y., 23-08-1993, : : FEBS Letters. 329, 1-2, p. 178-182 5 p.

研究成果: Article

25 引用 (Scopus)
1992

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

Saito, K., Markey, S. P. & Heyes, M. P., 11-1992, : : Neuroscience. 51, 1, p. 25-39 15 p.

研究成果: Article

161 引用 (Scopus)

Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid

Heyes, M. P., Saito, K. & Markey, S. P., 01-01-1992, : : Biochemical Journal. 283, 3, p. 633-635 3 p.

研究成果: Article

199 引用 (Scopus)