セルロースナノファイバーを用いたキシリトール打錠用顆粒の設計

Xylitol raw powder exhibits strong aggregation during storage, making it difficult to form fluidized bed and low compressibility. In this study, fluidized bed could be formed by co-milled with xylitol and fumed silica, and tabletability could also be improved by granulation with hydroxypropyl cellulose (HPC-L). To further improve the compressibility of xylitol, cellulose nanofiber (CN) was applied as a binder. As methods for adding CN, we investigated 1-step granulation method in which CN were added to the HPC-L binder solution and 2-step granulation method in which cellulose nanofibers are sprayed onto xylitol granules. In the 1-Step method, there was an optimum amount of CN. Addition of excess CN caused troubles during granulation and decreased the compressibility. In the 2-step method, the surfaces of xylitol granules were coated with CN. As a result, compressibility of the xylitol granules could be improved by only slight addition (13 ppm in xylitol) of CN.