14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain

Kazuhito Toyo-Oka, Tomoka Wachi, Robert F. Hunt, Scott C. Baraban, Shinichiro Taya, Hayley Ramshaw, Kozo Kaibuchi, Quenten P. Schwarz, Angel F. Lopez, Anthony Wynshaw-Boris

研究成果: Article査読

76 被引用数 (Scopus)

抄録

During brain development, neural progenitor cells proliferate and differentiate into neural precursors. These neural precursors migrate along the radial glial processes and localize at their final destination in the cortex. Numerous reports have revealed that 14-3-3 proteins are involved in many neuronal activities, although their functions in neurogenesis remain unclear. Here, using 14-3-3ε/ζ double knockout mice, we found that 14-3-3 proteins are important for proliferation and differentiation of neural progenitor cells in the cortex, resulting in neuronal migration defects and seizures. 14-3-3 deficiency resulted in the increase of δ-catenin and the decrease of β-catenin andαN-catenin. 14-3-3 proteins regulated neuronal differentiation into neurons via direct interactions with phosphorylated α-catenin to promote F-actin formation through a catenin/Rho GTPase/Limk1/cofilin signaling pathway. Conversely, neuronal migration defects seen in the double knock-out mice were restored by phosphomimic Ndel1 mutants, but notδ-catenin. Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades.

本文言語English
ページ(範囲)12168-12181
ページ数14
ジャーナルJournal of Neuroscience
34
36
DOI
出版ステータスPublished - 03-09-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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